Oxidized Low-Density Lipoprotein

Parthasarathy, S.; Raghavamenon, Achuthan C.; Garelnabi, Mahdi; Santanam, Nalini

doi:10.1007/978-1-60327-029-8_24

Cited by 268 publications

(200 citation statements)

References 154 publications

(61 reference statements)

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“…One mechanism that is linked with atherosclerosis is the presence of oxidated LDL [96]. There have been many studies performed using humans subjects to determine the effect of green tea catechins on lipids.…”

Section: Lipid Metabolismmentioning

confidence: 99%

An Update on the Health Benefits of Green Tea

Reygaert

2017

Beverages

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Abstract:Green tea, which is produced from the leaves of the Camellia sinensis plant, is one of the most popular beverages worldwide. Over the past 30 years or more, scientists have studied this plant in respect to potential health benefits. Research has shown that the main components of green tea that are associated with health benefits are the catechins. The four main catechins found in green tea are: (−)-epicatechin (EC), (−)-epicatechin-3-gallate (ECG), (−)-epigallocatechin (EGC), and (−)-epigallocatechin-3-gallate (EGCG). Of these four, EGCG is present in the largest quantity, and so has been used in much of the research. Among the health benefits of green tea are: anticarcinogenic, anti-inflammatory, antimicrobial, and antioxidant properties, and benefits in cardiovascular disease and oral health. Research has been carried out using various animal models and cells lines, and is now more and more being carried out in humans. This type of research will help us to better understand the direct benefits of green tea. This review will focus primarily on research conducted using human subjects to investigate the health benefits of green tea.

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Section: Lipid Metabolismmentioning

confidence: 99%

An Update on the Health Benefits of Green Tea

Reygaert

2017

Beverages

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“…46,47 Part of these results can be explained by the vascular dysfunction generated by the inflammatory process increase, increase of the oxidative process, and oxidation of the particles of LDL-c. 48,49 However, despite the strong correlation between atherosclerosis and vascular dysfunction, the results of the studies associating the lipid profile with arterial stiffness phenotypes are controversial. 50,51 Part of these contradictions can be justified, however, or by the differences between the populations investigated or by the different methods used in the determination of arterial stiffness.…”

Section: 42mentioning

confidence: 99%

Arterial Stiffness: Pathophysiological and Genetic Aspects

Alvim

Santos

Bortolotto

et al. 2017

International Journal of Cardiovascular Sciences

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Cardiovascular diseases (CVD) are the main cause of mortality and it represents a significant percentage of hospitalizations. In the scenario of minimization of costs of the health system, methods that identify subclinical CVD would be important. Some guidelines include the measures of aortic stiffness and intima-media thickness of the carotid artery as methods to identify subclinical CVD in hypertensive patients. The pulse wave velocity (PWV) is the gold standard for the evaluation of arterial stiffness. In this review, we report the pathophysiology, the determinants of arterial stiffness, and justify its inclusion in the assessment of hypertensive patient due its direct association with cardiovascular risk, as show in the I Diretriz Brasileira de Prevenção Cardiovascular. In addition, we raised the main genetic studies of this phenotype, due to its complexity, can be modulated by dozens of genes. However, a better understanding of the relationship genetic-arterial stiffness and, even an intervention based on genotypes, should be achieved in future studies.

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“…Foam cells form when macrophages or other cells uptake an excessive amount of LDL, and die. An oxidative hypothesis of atherosclerosis was proposed in 1989 and suggested modification of LDL as a primary reason of foam cell formation and development of atherosclerosis (Steinberget al, 1989;Parthasarathy et al, 2010). A massive amount of confirming data was collected since then.…”

Section: Oxidation Of Ldlmentioning

confidence: 99%