Oxidized low-density lipoprotein-induced CD147 expression and its inhibition by high-density lipoprotein on platelets in vitro

Yang, Shengwen; Li, Yuntian; Du, Da-Yong

doi:10.1016/j.thromres.2013.10.003

Cited by 17 publications

(12 citation statements)

References 54 publications

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“…In ocular fluids, synovial fluids, HEp-2 human laryngeal epidermoid carcinoma cells and human platelets or plasma, naturally soluble forms of EMMPRIN have also been discovered [19][20][21][22]. It has been shown that this protein can function both in the cell membrane and after being released from cells; however, knowledge on the functions of soluble EMMPRIN is relatively limited.…”

Section: Discussionmentioning

confidence: 99%

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Plasma EMMPRIN levels in acute myocardial infarction and stable coronary artery disease

Akkuş¹,

Ormam²,

Seyis³

et al. 2016

CIM

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Plasma EMMPRIN levels in acute myocardial infarction and stable coronary artery disease Abstract Purpose: The purpose of this study was to determine whether the plasma levels of soluble extracellular matrix metalloproteinase inducer (EMMPRIN) differed among the patients with ST-elevation myocardial infarction (STEMI), non-STEMI (NSTEMI) and stable coronary artery disease (CAD) and the healthy controls, and to identify the factors associated with the differences in plasma levels of this this protein among patients in these groups.Methods: Plasma EMMPRIN levels were compared among four age-and sex-matched groups of patients with STEMI, NSTEMI and stable CAD and healthy controls (n=44 per group), then logistic regression and correlation analyses were conducted for the whole acute myocardial infarction (AMI) patients group.Results: EMMPRIN levels were significantly higher in the STEMI (39.4±9.2ng/mL) and NSTEMI (37.1±10.5ng/mL) groups than in either the stable CAD (27.5±4.7ng/mL) or control (24.5±5.8ng/mL) groups (p<0.001 for each comparison), whereas the differences between the STEMI and NSTEMI groups, and between the stable CAD group and the controls, was not significant. Moreover, in the whole AMI patients group, the elevation of EMMPRIN was independent of the other variables (Odds ratio=1.25, 95% confidence intervals=1.16-1.34, p<0.001), and EMMPRIN levels were correlated significantly and positively with the plasma levels of peak creatine kinase-MB (r=0.22, p<0.05), peak cardiac troponin T (r=0.27, p<0.05) and admission C-reactive protein (r=0.26, p<0.05), and correlated significantly and inversely with left ventricular ejection fraction (r=-0.22, p< 0.05).Conclusion: EMMPRIN seems to play a role in the pathogenesis of AMI and its measurement in the plasma may play a role in the diagnosis of this disease.ORIGINAL RESEARCH

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Section: Discussionmentioning

confidence: 99%

“…According to the literature, EMMPRIN is released from tumor cells in at least two different ways. A significant amount of intact EMMPRIN is released from tumor cells, possibly contained within the membrane vesicles [22,27]. The other pathway is proteolytic shedding.…”

Section: Discussionmentioning

confidence: 99%

Plasma EMMPRIN levels in acute myocardial infarction and stable coronary artery disease

Akkuş¹,

Ormam²,

Seyis³

et al. 2016

CIM

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“…Moreover, NMR has shown that the CD147 Ig0–Ig1–Ig2, CD147 Ig1-Ig2 and CD147 Ig0 domains do not interact with each other [38], so there might exist some indirect interactions, but the mechanism(s) is unknown. Importantly, naturally soluble forms of CD147 have been discovered in ocular fluids, synovial fluids, HEp-2 human laryngeal epidermoid carcinoma cells and human platelets or plasma [42,45,46,47]. It should be further confirmed whether the roles of these soluble forms resemble the known transmembrane protein functions.…”

Section: Discovery and Molecular Characterization Of Cd147mentioning

confidence: 99%

“…Estradiol and GPR30 can increase CD147 expression in uterine cells [17,18]. Oxidized low-density lipoprotein enhances CD147 expression in human platelets and in coronary smooth muscle cells, whereas high-density lipoprotein or anti-LOX-1 monoclonal antibody decreases CD147 expression [47]. In particular, minocycline intervention significantly reduces the activity of CD147 and MMPs in atherosclerotic plaque tissue, and histology studies have demonstrated enhanced plaque stabilization [171].…”

Section: Additional Regulatory Mechanisms Controlling Cd147 Expresmentioning

confidence: 99%

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

Xiong

Edwards

Zhou

2014

IJMS

186

194

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CD147 or EMMPRIN is a member of the immunoglobulin superfamily in humans. It is widely expressed in human tumors and plays a central role in the progression of many cancers by stimulating the secretion of matrix metalloproteinases (MMPs) and cytokines. CD147 regulates cell proliferation, apoptosis, and tumor cell migration, metastasis and differentiation, especially under hypoxic conditions. CD147 is also important to many organ systems. This review will provide a detailed overview of the discovery, characterization, molecular structure, diverse biological functions and regulatory mechanisms of CD147 in human physiological and pathological processes. In particular, recent studies have demonstrated the potential application of CD147 not only as a phenotypic marker of activated regulatory T cells but also as a potential diagnostic marker for early-stage disease. Moreover, CD147 is recognized as an effective therapeutic target for hepatocellular carcinoma (HCC) and other cancers, and exciting clinical progress has been made in HCC treatment using CD147-directed monoclonal antibodies.

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“…Ox-LDL is involved in initiation of atherosclerotic lesions, inducing not only foam cell formation and vascular endothelial damage but also platelet interaction during with circulation. Yang et al [47] found that ox-LDL stimulates platelet CD147 expression and sCD147 release via binding to LOX-1 and that HDL inhibits this effect.…”

Section: Roles Of Platelet Cd147mentioning

confidence: 99%

Function of CD147 in Atherosclerosis and Atherothrombosis

Wang

Jin

Zhu

et al. 2015

J. of Cardiovasc. Trans. Res.

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CD147, a member of the immunoglobulin super family, is a well-known potent inducer of extracellular matrix metalloproteinases. Studies show that CD147 is upregulated in inflammatory diseases. Atherosclerosis is a chronic inflammatory disease of the artery wall. Further understanding of the functions of CD147 in atherosclerosis and atherothrombosis may provide a new strategy for preventing and treating cardiovascular disease. In this review, we discuss how CD147 contributes to atherosclerosis and atherothrombosis.

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Oxidized low-density lipoprotein-induced CD147 expression and its inhibition by high-density lipoprotein on platelets in vitro

Cited by 17 publications

References 54 publications

Plasma EMMPRIN levels in acute myocardial infarction and stable coronary artery disease

Plasma EMMPRIN levels in acute myocardial infarction and stable coronary artery disease

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

Function of CD147 in Atherosclerosis and Atherothrombosis

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