“…For example, recent evidence suggests that oxidized LDL induces apoptosis both through activation of death receptors and through mitochondrial pathways. It has also recently been reported that the oxysterols, lipid hydroperoxides, oxidized phospholipids, and free cholesterol found within oxidized LDL independently induce death (2,5,11,27,28,30,36,47,50,51,(53)(54)(55). In the present study and in keeping with previous observations, it was found that even very low concentrations of oxidized LDL were capable of inducing markers of apoptosis in the RAW cells, C. pneumoniae is an obligate intracellular pathogen, and as such this organism is dependent on the continued functioning of the host cell to support bacterial growth and the capacity for sustained infection.…”