Oxidative Stress

Ortíz, Genaro Gabriel; Moisés, Fermín Paul Pacheco; Mireles-Ramírez, Mario Alberto; Flores-Alvarado, Luis Javier; González-Usigli, Héctor; Sánchez-González, Víctor J.; Sánchez-López, Angélica Lizeth; Sánchez-Romero, Lorenzo; Díaz-Barba, Eduardo I; Santoscoy-Gutiérrez, J Francisco; Rivero-Moragrega, Paloma

doi:10.1016/bs.apcsb.2017.01.003

Cited by 48 publications

(13 citation statements)

References 41 publications

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“…Reactive oxygen species (ROS) are produced in all living organisms as byproducts of normal metabolic reactions and as a result of xenobiotic exposure [21]. Under physiological conditions, they play an important role in cellular signaling throughout the body [22], but in excess they are harmful to all cell types, including nerve cells [21]. Oxidative stress caused by an imbalance between production and elimination of ROS is linked to the pathogenesis of numerous diseases [23,24].…”

Section: Neurobiological Processes Leading To Admentioning

confidence: 99%

Potential Role of Fluoride in the Etiopathogenesis of Alzheimer’s Disease

Goschorska

Baranowska-Bosiacka

Gutowska

et al. 2018

IJMS

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The etiopathogenesis of Alzheimer’s disease has not been fully explained. Now, the disease is widely attributed both to genetic and environmental factors. It is believed that only a small percentage of new AD cases result solely from genetic mutations, with most cases attributed to environmental factors or to the interaction of environmental factors with preexistent genetic determinants. Fluoride is widespread in the environment and it easily crosses the blood–brain barrier. In the brain fluoride affects cellular energy metabolism, synthesis of inflammatory factors, neurotransmitter metabolism, microglial activation, and the expression of proteins involved in neuronal maturation. Finally, and of specific importance to its role in Alzheimer’s disease, studies report fluoride-induced apoptosis and inflammation within the central nervous system. This review attempts to elucidate the potential relationship between the effects of fluoride exposure and the pathogenesis of Alzheimer’s disease. We describe the impact of fluoride-induced oxidative stress and inflammation in the pathogenesis of AD and demonstrate a role for apoptosis in disease progression, as well as a mechanism for its initiation by fluoride. The influence of fluoride on processes of AD initiation and progression is complex and warrants further investigation, especially considering growing environmental fluoride pollution.

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Section: Neurobiological Processes Leading To Admentioning

confidence: 99%

Potential Role of Fluoride in the Etiopathogenesis of Alzheimer’s Disease

Goschorska

Baranowska-Bosiacka

Gutowska

et al. 2018

IJMS

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“…Oxidative stress is one of the major pathological components of neurodegenerative diseases, causing systemic cellular damage involving oxidized lipids, proteins, RNA, and DNA [ 76 , 77 ]. The oxidative DNA repair pathway, BER, is tightly bound to the survival fate of neurons.…”

Section: Dna Damage and Repair In Neurological Disordersmentioning

confidence: 99%

The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders

Yang

Chen

2017

IJMS

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Glucagon-like peptide-1 (GLP-1) is originally found as a metabolic hormone (incretin) that is able to regulate blood-glucose levels via promoting synthesis and secretion of insulin. GLP-1 and many analogues are approved for treatment of type II diabetes. Accumulating results imply that GLP-1 performs multiple functions in various tissues and organs beyond regulation of blood-glucose. The neuroprotective function of GLP-1 has been extensively explored during the past two decades. Three of our previous studies have shown that apurinic/apyrimidinic endonuclease 1 (APE1) is the only protein of the base excision repair (BER) pathway able to be regulated by oxidative stress or exogenous stimulations in rat primary cortical neurons. In this article, we review the role of APE1 in neurodegenerative diseases and its relationship to neuroprotective mechanisms of the activated GLP-1 receptor (GLP-1R) in neurodegenerative disorders. The purpose of this article is to provide new insight, from the aspect of DNA damage and repair, for studying potential treatments in neurodegenerative diseases.

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“…The disease affects elderly people throughout the world and it usually starts slowly and worsens over time. It has also been found that the efficiency of the brain’s antioxidant system gradually decreases with age, and this is more so in AD patients [2]. Several molecular mechanisms of AD have been proposed, including the cholinergic hypothesis, β-amyloid cascade, oxidative stress, and metal imbalance [3].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Novel 7-Substituted 6-iodo-3-O-Flavonol Glycosides against Cholinesterases and β-secretase Activities, and Evaluation for Potential Antioxidant Properties

2019

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A series of 7-halogeno- (X = F, Cl, Br) and 7-methoxy-substituted acetylated 6-iodo-3-O-flavonol glycosides were prepared, and evaluated for inhibitory effect in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. 7-Bromo-2-(4-chlorophenyl)-6-iodo-4H-chromen-4-one-3-O-2,3,4,6-O-tetraacetyl-β-d-glucopyranoside (2k) and 7-bromo-6-iodo-2-(4-methoxyphenyl)-4H-chromen-4-one-3-O-2,3,4,6-O-tetraacetyl-β-d-glucopyranoside (2l) exhibited significant inhibitory effect against AChE activity when compared to the activity of the reference standard, donepezil. Compound 2k was found to be selective against AChE and to exhibit reduced inhibitory effect against BChE activity. 6-Iodo-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one-3-O-2,3,4,6-O-tetraacetyl-β-d-glucopyranoside (2p) was found to exhibit increased activity against BChE, more so than the activity of donepezil. The most active compounds were also evaluated for inhibitory effect against β-secretase activity and for potential radical scavenging activities. The experimental data were complemented with molecular docking (in silico) studies of the most active compounds into the active sites of these enzymes.

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Oxidative Stress

Cited by 48 publications

References 41 publications

Potential Role of Fluoride in the Etiopathogenesis of Alzheimer’s Disease

Potential Role of Fluoride in the Etiopathogenesis of Alzheimer’s Disease

The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders

Inhibitory Effects of Novel 7-Substituted 6-iodo-3-O-Flavonol Glycosides against Cholinesterases and β-secretase Activities, and Evaluation for Potential Antioxidant Properties

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