Oxidative stress: the lowest common denominator of multiple diseases

Matschke, Veronika; Theiß, Carsten; Matschke, Johann

doi:10.4103/1673-5374.244780

Cited by 56 publications

(54 citation statements)

References 23 publications

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“…Oxidative stress is thought to play a pivotal role in a significant range of diseases, including cardiovascular and neurodegenerative diseases, diabetes, autoimmune processes, and cancer [ 62 ]. Moreover, inflammation is being positively correlated with chronic metabolic and inflammatory diseases associated with modern lifestyle [ 63 ], and a close relationship between oxidative stress and inflammation is established [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Unraveling the Lipidome and Antioxidant Activity of Native Bifurcaria bifurcata and Invasive Sargassum muticum Seaweeds: A Lipid Perspective on How Systemic Intrusion May Present an Opportunity

et al. 2020

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Brown seaweeds are known to present components with appealing bioactive properties eliciting great interest for industrial applications. However, their lipid content is generally disregarded beyond their fatty acid (FA) composition. This study thoroughly characterized the lipid profile of two brown seaweeds collected from Portuguese coast, the native Bifurcaria bifurcata and the invasive Sargassum muticum species, and bioprospecting for antioxidant activity. An integrated state-of-the-art approach including gas chromatography-mass spectrometry (GC–MS) and liquid chromatography-mass spectrometry (HILIC–ESI-MS/MS), allowed a comprehensive picture of FA and polar lipid content. Polar lipid profile of B. bifurcata and S. muticum included 143 and 217 lipid species respectively, distributed between glycolipids, phospholipids, and betaine lipids. Some of the lipid species found have been assigned biological activity and contain of n-3 and n-6 FA. Sargassum muticum presented the highest n-3 FA content. Low concentrations of extracts of both seaweeds displayed antioxidant activity, with S. muticum presenting more promising results. These findings contribute to the nutritional and industrial exploitation of both seaweeds, highlighting their relevance as viable sources of bioactive and added-value compounds. Sargassum muticum presented interesting lipid composition and bioactivity, which may represent an accessible opportunity for the exploitation of this invasive seaweed, especially taking advantage of Sargassum blooms.

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Section: Discussionmentioning

confidence: 99%

Unraveling the Lipidome and Antioxidant Activity of Native Bifurcaria bifurcata and Invasive Sargassum muticum Seaweeds: A Lipid Perspective on How Systemic Intrusion May Present an Opportunity

et al. 2020

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“…Oxidative stress has been implicated in the development and complications of diabetes, obesity, cardiovascular diseases, Alzheimer's disease, and ageing [40,41]. Oxidation of components of animal cells can result in cellular damage leading to the development of various pathologies.…”

Section: Discussionmentioning

confidence: 99%

Fruiting Body of Pleurotus Ostreatus Reduces Serum Glucose and Modifies Oxidative Stress in Type 2 Diabetic: Drosophila Melanogaster (Fruit-Fly)

Omale¹,

Aguiyi²,

Bukar³

et al. 2020

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Mushrooms, which possess medicinal properties, are also considered a good source of food and basic nutrients. Diabetic patients now use edible mushrooms as a source of low-calorie food. Mushrooms are used to treat and prevent diseases such as diabetes, obesity, heart disease, hyperacidity, cancer, hypertension and also act as immune modulators. In this study, the antidiabetic and antioxidant effects of the fruiting body of Pleurotus ostreatus (PO) in sucrose-induced type-2 diabetic Drosophila melanogaster was investigated. The fresh fruiting body of PO was obtained from the mushroom farm of the Africa Centre of Excellence in Phytomedicine Research and Development (ACEPRD) and dried with the aid of the ASPRE dryer. The aqueous extract of the dried powder was used for the anti-diabetic and survival assay. The fly homogenate was evaluated for circulating glucose, total thiol, acetylcholinesterase, catalase and glutathione-S-transferase. PO was observed to prolong D. melanogaster's survival time as more flies (> 50%) survived on the extract compared to control (47%), after 28 days. There was a significant (P < 0.05) decrease in the circulating glucose of the treated flies compared with those that were untreated; while no statistical (P > 0.05) difference was observed between the metformin and PO treated groups. In the antioxidant study, an insignificant (P > 0.05) difference between the untreated and treated groups was observed. Catalase activity showed a significant (P < 0.05) difference between the diabetic untreated and PO treated groups. We conclude that the fruiting body of P. ostreatus possessed potent hypoglycemic activities in D. melanogaster induced type-2 diabetes, possibly linked to its antioxidant property.

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“…Reactive Oxygen Species (ROS) generated in the mitochondria promote the expression of proinflammatory cytokines and chemokines, thus playing a key role in modulating innate immune responses against RNA viruses [85][86][87][88][89] . Mitochondrially-targeted glutathione S-transferase, GSTM1, which was more highly expressed in African Americans than European Americans, is a key enzyme in the metabolism of ROS, as well as xenobiotics including pharmaceuticals 88 .…”

Section: Discussionmentioning

confidence: 99%

Differential expression of COVID-19-related genes in European Americans and African Americans

Singh

Wurtele

2020

Preprint

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The Coronavirus disease 2019 (COVID-19) pandemic has affected African American populations disproportionately in regards to both morbidity and mortality. A multitude of factors likely account for this discrepancy. Gene expression represents the interaction of genetics and environment. To elucidate whether levels of expression of genes implicated in COVID-19 vary in African Americans as compared to European Americans, we re-mine The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) RNA-Seq data. Multiple genes integral to infection, inflammation and immunity are differentially regulated across the two populations. Most notably, F8A2 and F8A3, which encode the HAP40 protein that mediates early endosome movement in Huntington’s Disease, are more highly expressed by up to 24-fold in African Americans. Such differences in gene expression can establish prognostic signatures and have critical implications for precision treatment of diseases such as COVID-19. We advocate routine inclusion of information such as postal code, education level, and profession (as a proxies for socioeconomic condition) and race in the metadata about each individual sampled for sequencing studies. This relatively simple change would enable large-scale data-driven approaches to dissect relationships among race, socio-economic factors, and disease.

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Oxidative stress: the lowest common denominator of multiple diseases

Cited by 56 publications

References 23 publications

Unraveling the Lipidome and Antioxidant Activity of Native Bifurcaria bifurcata and Invasive Sargassum muticum Seaweeds: A Lipid Perspective on How Systemic Intrusion May Present an Opportunity

Unraveling the Lipidome and Antioxidant Activity of Native Bifurcaria bifurcata and Invasive Sargassum muticum Seaweeds: A Lipid Perspective on How Systemic Intrusion May Present an Opportunity

Fruiting Body of Pleurotus Ostreatus Reduces Serum Glucose and Modifies Oxidative Stress in Type 2 Diabetic: Drosophila Melanogaster (Fruit-Fly)

Differential expression of COVID-19-related genes in European Americans and African Americans

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