Oxidative stress status in patients with melasma

Seçkin, Havva Yıldız; Kalkan, Göknur; Baş, Yalçın; Akbaş, Ali; Önder, Yalçın; Özyurt, Hüseyın; Şahin, Mehmet

doi:10.3109/15569527.2013.834496

Cited by 54 publications

(65 citation statements)

References 34 publications

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“…[28] In this study there is no significant correlation between MDA levels with severity of melasma (p> 0.05), but there is a tendency of increasing severity of melasma in higher levels of MDA. (Table 6) This is consistent with the results of research by Seckin et al (2013) that failed to show a significant relationship between levels of serum MDA with MASI values (p> 0.05). [12] Oxidative stress is an imbalance between prooxidant state with antioxidant, because ROS formation exceeds the ability of the antioxidant defense system, or decrease, or the constant state of antioxidant capability.…”

Section: Discussionsupporting

confidence: 82%

“…[26] MDA is an end product of lipid peroxidation membrane and is one of a biomarker of oxidative stress. [12] In Table 5 is also evident that the group of Melasma, found a significant positive correlation between the duration score of exposure to sunlight with MDA levels (p <0.001), where the higher the score, the higher the duration of exposure to MDA. Coefficient correlation between the two variables is strong (R = 0.669), while in the control group, there were no significant correlation between the duration score of exposure to MDA levels (p> 0.05) but there is a tendency of increasing the duration of sun exposure, MDA has increased as well.…”

Section: Discussionmentioning

confidence: 81%

“…Additionally, keratinocytes after exposure to ultraviolet light produced some alpha mediators such as interleukin (ILalpha) and endothelin-1 (ET-1), which stimulate melanogenesis. [8,12] This suggests that elevated levels of MDA in patients with melasma can be generated from increased oxidative stress and tissue damage.…”

Section: Discussionmentioning

confidence: 99%

“…The results showed a balance between oxidants and anti-oxidants have been disrupted and oxidative stress increased on melasma. [12] The study by Sari et al (2014) showed a positive correlation between levels of MDA serum with MASI value in patients with melasma, with a coefficient correlation value of r: 0913, and p <0.001. Additionally MDA serum levels obtained in subjects with melasma is higher (0.4737 ± 0.18594 µM / L) compared to subjects with no melasma (0.2459 ± 0.5871 µM / L), with p <0.001.…”

Section: Introductionmentioning

confidence: 99%

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The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar

Zainuddin¹,

Anwar²,

Djawad³

et al. 2016

AJCEM

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Ultraviolet (UV) plays an important role in the pathogenesis of melasma. Ultraviolet rays can cause lipid peroxidation in cell membranes that trigger the generation of free radicals that can stimulate melanocytes to produce many melanin. Malondialdehyde (MDA) is the end product of lipid peroxidation in the body. MDA is an important indicator of lipid peroxidation. There are a lot of research has been done in linking MDA to the severity of melasma. But there has not yet any research connecting it with sun exposure in patients with melasma. This study aims to find out the relationship between MDA serum levels and the duration of sun exposure; and Melasma Area and Severity Index (MASI) scores in patients with melasma. The research method was the case control study. It used 84 samples divided into two groups: a melasma group consisting of 42 people and a control group consisting of 42 people. The examination was performed with anamnesis, questionnaires, duration score of sun exposure, physical examination and the assessment of MDA serum levels with Thiobutiric acid-reactive substance test reaction. The data were analysed using independent t test, Mann Whitney, and Spearman correlation test. The results show that there is a significant correlation between the levels of MDA with the duration of sun exposure, but the duration of sun exposure is not associated with MASI score. It means that MDA levels are not significantly associated with MASI scores. Free radicals are significantly associated with the duration of sun exposure, but the severity of melasma is not affected by the duration of sun exposure. The severity level of melasma is still much influenced by some other risk factors associated with the pathogenesis of melasma.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar

Zainuddin¹,

Anwar²,

Djawad³

et al. 2016

AJCEM

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“…While a genetic component is probably involved in melasma, sun exposure and hormonal changes/ imbalance are exacerbating factors but not causative ones. As there were no studies evaluating the role of oxidative stress in melasma, it was recently reported for the first time that the balance between oxidants and antioxidants was disrupted and oxidative stress was increased in melasma [43]. Prior to this finding, various antioxidants had been reported in the past as improving melasma.…”

Section: Melasmamentioning

confidence: 91%

Melanocytes and Oxidative Stress

Diehl¹

2014

Pigmentary Disorders

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Melasma hyperpigmentation: An overview of current topical therapeutics

AlSalem

Alexis

2022

Dermatological Reviews

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Background Melasma is a common disorder of hyperpigmentation that affects populations globally and can adversely affect quality of life. Topical therapies—including hydroquinone and nonhydroquinone‐containing formulations—play a central role in the management of melasma. Methods A literature review was conducted using PubMed and Google Scholar. Search keywords included a combination of the following: “melasma,” “chloasma,” and “topical treatment.” We identified and included seminal and high‐quality peer‐reviewed publications, systematic reviews, randomized controlled trials, case series, case reports, consensus statements, and expert opinions. Results Topical therapies are widely used for the treatment of melasma. Triple combination cream containing hydroquinone, fluocinolone, and tretinoin is the most studied formulation with the strongest evidence among treatment options. Numerous other prescription‐based and nonprescription topical agents, including a growing list of cosmeceuticals, have been used in the treatment of melasma, albeit in smaller studies. Conclusion A growing range of topical agents is available for the treatment of melasma. While larger, more robust studies are warranted, nonhydroquinone cosmeceuticals may be useful adjuncts or alternatives to the gold standard of triple‐combination hydroquinone cream.

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Oxidative stress status in patients with melasma

Abstract: The results show that the balance between oxidant and anti-oxidants was disrupted and the oxidative stress increased in melasma. These results improve the understanding of etiology-pathogenesis of the disease and its treatment.

Cited by 54 publications

References 34 publications

The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar

The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar

Melanocytes and Oxidative Stress

Melasma hyperpigmentation: An overview of current topical therapeutics

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