Oxidative stress status in patients with chronic idiopathic urticaria

Sagdic, A.; Şener, Osman; Bulucu, Fatih; Karadurmuş, Nuri; Yamanel, Levent; Tasci, Canturk; Naharci, Mehmet İlkin; Öcal, Ruhşen; Aydın, Attila

doi:10.1016/j.aller.2010.06.012

Cited by 19 publications

(19 citation statements)

References 17 publications

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“…Results might also be influenced by the study population, which consists of female patients only, because the expression of some antioxidant enzymes, including those that are evaluated in their study, and others, like paraoxonase-2, is influenced by gender and sex hormones [ 39 , 40 ]. Sagdic et al reported that patients with CU have similar erythrocyte MDA levels and GSH-PX activities and decreased Cu/Zn SOD activities compared to healthy controls [ 36 ]. However, only 25 patients are enrolled in this study; hence, the small sample size makes it difficult to demonstrate the difference between the groups statistically.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Children with Chronic Spontaneous Urticaria

Dilek

Özçeker

Özkaya

et al. 2016

Oxidative Medicine and Cellular Longevity

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The pathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood; nevertheless, significant progress has been achieved in recent years. The aim of this study was to investigate the possible role of reactive oxygen species (ROS) in the pathogenesis of CSU. Sixty-two children with CSU and 41 healthy control subjects were enrolled in the study. An extensive evaluation of demographic and clinical features was done, and serum oxidative stress was evaluated by plasma total oxidant status (TOS) and total antioxidant status (TAS) measurements. The median value of plasma TOS was found to be 10.49 μmol H2O2 equiv./L (interquartile range, 7.29–17.65) in CSU patients and 7.68 μmol H2O2 equiv./L (5.95–10.39) in the control group. The difference between the groups was statistically significant (p = 0.003). Likewise, the median plasma TAS level in the CSU group was decreased significantly compared to that of the control group (2.64 [2.30–2.74] versus 2.76 [2.65–2.86] mmol Trolox equiv./L, resp., p = 0,001). Our results indicated that plasma oxidative stress is increased in children with CSU when compared to healthy subjects, and plasma oxidative stress markers are positively correlated with disease activity.

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Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Children with Chronic Spontaneous Urticaria

Dilek

Özçeker

Özkaya

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…In the present study we evaluated serum levels of AOPPs, AGEs in patients affected by chronic urticaria, a disease in which findings on the presence or absence of oxidative stress are controversial [ 12 , 13 , 15 , 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies suggest the presence of an oxidative insult in physical urticaria [ 11 ], acute urticaria [ 19 ], chronic idiopathic urticaria [ 12 , 13 , 18 ] and CSU [ 17 ] but other authors did not find significant differences in oxidative stress markers and/or antioxidant capacity between patients with urticaria and controls [ 15 , 16 ] or found that a full oxidative stress does not occur due to well-preserved functions of other scavenger enzymes [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

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Involvement of new oxidative stress markers in chronic spontaneous urticaria

Nettis

Distaso

Saitta

et al. 2017

pdia

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IntroductionOxidative stress is a result of an imbalance between endogenous production of free reactive oxygen species and reduced effectiveness of antioxidant defence mechanisms. Advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) are compounds formed by transformation of macromolecules, including proteins which can serve as markers of oxidative stress and inflammation in several diseases.AimTo investigate the role of AGEs and AOPPs as new markers of oxidative stress and inflammation in patients with chronic spontaneous urticaria (CSU).Material and methodsAdvanced glycation end products and AOPP levels were determined in the sera of 85 patients with CSU and 64 healthy controls, using spectrofluorimetry and spectrophotometry, respectively.ResultsAdvanced oxidation protein products levels in patients were statistically higher than those in controls. These levels were not affected by the presence of positive autologous serum test results or autologous plasma test results. No statistically significant differences were found between AGE levels in patients and controls.ConclusionsFormation of AGEs and AOPPs may be accelerated in immunological and allergic disorders. Depending on the sites evaluated, the presence or absence of oxidative stress in chronic urticaria is controversial. To our knowledge, this is the first study showing the possible involvement of AOPPs in CSU. The different behaviour observed for these two biomarkers is very likely due to the activation of specific related biochemical pathways associated with the condition under study.

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“…Very few studies have been found in the literature on the presence of alexithymia in patients with past CIU. 41 , 42 …”

Section: Discussionmentioning

confidence: 99%

Sense of alexithymia in patients with anxiety disorders comorbid with recurrent urticaria

Ogłodek

Szota

Just

et al. 2016

NDT

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AimAlexithymia is associated with limited cognitive processing of emotions by an individual suffering from recurrent urticaria and alexithymia and makes them focus on somatic manifestations of emotional arousal and on poorly controlled compulsive reactions to negative stimulation. Alexithymia is considered to be a personality trait, which, along with other factors, predisposes individuals toward developing somatic diseases. The aim of the study was to assess the measurement of alexithymic features in patients with recurrent urticaria and to assess the types of concurrent anxiety disorders and overall anxiety level.MethodsIn order to diagnose clinical anxiety symptoms in patients, the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and the Hamilton Anxiety Rating Scale were applied. Alexithymic features were measured by means of a shortened version of the Toronto Alexithymia Scale, characterized by high discrimination power, internal coherence, and reliability.ResultsAccording to the Toronto Alexithymia Scale results, the greatest contributing factor was “inability to differentiate between feelings and bodily sensations”. This was observed in both males and females. Most frequently, the patients were found to suffer from generalized anxiety disorder and social phobia.ConclusionAlexithymia may result from the difficulty associated with expressing emotions caused by anxiety disorders. Undergoing treatment for anxiety disorders may contribute to reduced exacerbation of urticaria.

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Oxidative stress status in patients with chronic idiopathic urticaria

Cited by 19 publications

References 17 publications

Oxidative Stress in Children with Chronic Spontaneous Urticaria

Oxidative Stress in Children with Chronic Spontaneous Urticaria

Involvement of new oxidative stress markers in chronic spontaneous urticaria

Sense of alexithymia in patients with anxiety disorders comorbid with recurrent urticaria

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