Oxidative Stress Status in Childhood Obesity: A Potential Risk Predictor

Abstract

BackgroundChildhood obesity characterized by excessive fat in the body is one of the most serious health problems worldwide due to the social, medical, and physiological complications. Obesity and associated diseases are triggering factors for oxidative stress and inflammation. The aim of this study was to explore the possible association between childhood obesity and inflammatory and oxidative status.Material/MethodsThirty-seven obese children and 37 healthy controls selected from among children admitted to BLIND University Paediatrics Department were included in the study. Anthropometric measurements were performed using standard methods. Glucose, lipid parameters, CRP, insulin, total oxidant status (TOS), total anti-oxidant status (TAS) levels, and total thiol levels (TTL) were measured in serum. HOMA index (HOMA-IR) were calculated. The differences between the groups were evaluated statistically using the Mann-Whitney U test.ResultsBody mass index was significantly higher in the obese group (median: 28.31(p<0.001). Glucose metabolism, insulin, and HOMA-IR levels were significantly higher in the obese group (both p<0.001). Total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceride levels were significantly higher in the obese group (p<0.001). TAS (med: 2.5 μmol Trolox eq/L (1.7–3.3)) and TOS (med: 49.1 μmol H2O2 eq/L (34.5–78.8)) levels and TTL (med: 0.22 mmol/L (0.16–0.26)) were significantly higher in the obese group (p=0.001). CRP levels showed positive correlation with TOS and negative correlation with TTL levels (p=0.005, r=0.473; p=0.01, r=−0.417; respectively). TTL levels exhibited negative correlation with TOS levels (p=0.03, r=−0.347).ConclusionsIn conclusion, obese children were exposed to more oxidative burden than children with normal weight. Increased systemic oxidative stress induced by childhood obesity can cause development of obesity-related complications and diseases. Widely focussed studies are required on the use of oxidative parameters as early prognostic parameters in detection of obesity-related complications.

Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status

“…Although there are several available definitions of MU status, there is evidence that both childhood obesity and MU status increase cardiovascular disease risk in adulthood [4,5]. Moreover, systemic inflammation and endothelial damage have also been described in children with obesity [6,7], as well as increased oxidative stress [8,9]. The relationship between oxidative stress, obesity, and cardiometabolic disease seems to be a consequence of low-grade inflammation [10].…”

Obesity induced alterations in redox homeostasis and oxidative stress are present from an early age

“…Some have suggested this may vary according to the degree of the disease development and/or severity [ 8 ]. Nevertheless, most published studies measure these biomarkers in basal conditions [ 9 , 10 ], but their dynamics after a stressor, such as a glucose overload (OGTT), and more specifically, at pediatric age has not been explored yet.…”

Alpha‐ and gamma‐tocopherol levels in human semen and their potential functional implications

“…However, Omu, Fatinikun, Mannazhath, and Abraham (1999) reported that α-TOH concentration is higher in blood than in semen and that concentration was higher in samples of (2009) showed an association between low semen α-TOH concentration and altered sperm function in 40 patients with different seminal parameters. However, the authors considered only obese men with an average BMI of about 35, which is known to affect the antioxidant status (Kilic et al, 2016;Ozata et al, 2002). Our patients had a BMI < 30 kg/m 2 and a comparable smoking status.…”