Oxidative stress status and vitamin D levels of asymptomatic to mild symptomatic COVID‐19 infections during the third trimester of pregnancy: A retrospective study in Metz, France

Schmitt, Guillaume; Labdouni, Sary; Soulimani, Rachid; Delamare, Catherine; Bouayed, Jaouad

doi:10.1002/jmv.27606

Cited by 14 publications

(26 citation statements)

References 37 publications

(102 reference statements)

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“…This suggests an alteration in the systemic redox status [ 8 ]. In another retrospective study in France by Schmitt et al that enrolled 15 pregnant women with and without COVID-19 during their third trimester, no differences were shown between CRP levels and OS markers between groups [ 30 ]. Another report from Iran by Karkhanei et al including 96 individuals with and without COVID-19 found that elevation in serum levels of OS (reduced glutathione and TAC) and reduction of antioxidant indices (total oxidant status) could aggravate the disease's severity in hospitalized patients with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress Biomarkers and Their Association with Mortality among Patients Infected with SARS-CoV-2 in Mexico

Ávila-Nava

Pech-Aguilar

Lugo

et al. 2022

Oxidative Medicine and Cellular Longevity

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Background. Activation of the immune system response is associated with the generation of oxidative stress (OS). Several alterations are involved in OS, such as excessive production of reactive oxygen species (ROS) and decreased antioxidant activity, which together lead to an imbalance in redox status. The role of OS during SARS-CoV-2 infection is not fully understood. The aim of this study was to determine OS biomarkers and assess their usefulness as a predictor of mortality in COVID-19 patients. Methods. Baseline characteristics and serum samples were collected from hospitalized COVID-19 patients and compared with healthy controls. The serum OS biomarkers, including malondialdehyde (MDA) and total antioxidant capacity (TAC), were assessed by spectrophotometric and oxygen radical absorbance capacity (ORAC) methods, respectively. Results. A total of 152 individuals were analyzed (COVID-19 patients vs. healthy controls). Compared with healthy controls ( n = 76 ), patients infected with SARS-CoV-2 ( n = 76 ) presented higher levels of MDA ( p < 0.001 ) and decreased TAC ( p < 0.001 ). A total of 37 (49%) patients with COVID-19 died. The area under the receiver operating characteristic (ROC) curve (AUC) estimated that the combination of the OS biomarkers (MDA+TAC) ( AUC = 0.6394 , p = 0.037 ) was a significant predictor of mortality. A higher level of MDA was associated with mortality (HR, 1.05, 95% CI, 1.00–1.10, p = 0.045 ). Conclusion. This study concludes that OS is increased in patients with COVID-19 and is associated with mortality. To our knowledge, this is the first evidence of the expression of OS biomarkers and their association with mortality among the Mexican population.

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Section: Discussionmentioning

confidence: 99%

Oxidative Stress Biomarkers and Their Association with Mortality among Patients Infected with SARS-CoV-2 in Mexico

Ávila-Nava

Pech-Aguilar

Lugo

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Sinaci et al [50] showed that the levels of vitamin D in pregnant women with moderate/severe courses of COVID-19 were lower (13.69 ng/mL) compared to those of pregnant women with a mild approach (13.69 ng/mL). In addition, Schmitt et al [51] obtained similar results. They showed that the level of vitamin D in pregnant women (patients and controls) was <20 ng/mL, while in the case of mild COVID-19, the level of vitamin D in pregnant patients was lower (<12 ng/mL) [51].…”

Section: Natural Antioxidants To Treat or Support Covid-19 Patients?mentioning

confidence: 68%

“…In addition, Schmitt et al [51] obtained similar results. They showed that the level of vitamin D in pregnant women (patients and controls) was <20 ng/mL, while in the case of mild COVID-19, the level of vitamin D in pregnant patients was lower (<12 ng/mL) [51].…”

Section: Natural Antioxidants To Treat or Support Covid-19 Patients?mentioning

confidence: 68%

The Variable Nature of Vitamin C—Does It Help When Dealing with Coronavirus?

et al. 2022

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still spreading worldwide. For this reason, new treatment methods are constantly being researched. Consequently, new and already-known preparations are being investigated to potentially reduce the severe course of coronavirus disease 2019 (COVID-19). SARS-CoV-2 infection induces the production of pro-inflammatory cytokines and acute serum biomarkers in the host organism. In addition to antiviral drugs, there are other substances being used in the treatment of COVID-19, e.g., those with antioxidant properties, such as vitamin C (VC). Exciting aspects of the use of VC in antiviral therapy are its antioxidant and pro-oxidative abilities. In this review, we summarized both the positive effects of using VC in treating infections caused by SARS-CoV-2 in the light of the available research. We have tried to answer the question as to whether the use of high doses of VC brings the expected benefits in the treatment of COVID-19 and whether such treatment is the correct therapeutic choice. Each case requires individual assessment to determine whether the positives outweigh the negatives, especially in the light of populational studies concerning the genetic differentiation of genes encoding the solute carriers responsible forVC adsorption. Few data are available on the influence of VC on the course of SARS-CoV-2 infection. Deducing from already-published data, high-dose intravenous vitamin C (HDIVC) does not significantly lower the mortality or length of hospitalization. However, some data prove, among other things, its impact on the serum levels of inflammatory markers. Finally, the non-positive effect of VC administration is mainly neutral, but the negative effect is that it can result in urinary stones or nephropathies.

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“…In literature, a comparative case-control study in a pregnant population of 82 positive and 174 negative women (controls) suggested serum 25-vitamin D levels were significantly lower in positive pregnant women than in controls at the time of delivery [11]. However, as the main study limitation, only a single timing of blood collection was considered.…”

Section: Discussionmentioning

confidence: 99%

“…Schmitt et al have recently measured vitamin D levels and attempted to correlate them with the severity of COVID-19 [11]. They found that both positive and negative women had low levels of vitamin D in the third trimester.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy and COVID-19: The Possible Contribution of Vitamin D

et al. 2022

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Background: Vitamin D deficiency has been associated with the severity of COVID-19. The role of vitamin D in pregnant women with COVID-19 has been poorly investigated to date. The aim of this study was to evaluate the influence of vitamin D in affecting some clinical features in pregnancy between SARS-CoV-2 positive and negative patients. Methods: Vitamin D pathway related polymorphisms and 25-hydroxyvitamin D levels were quantified in pregnant women followed from the first to the third trimester of pregnancy. Vitamin D deficiency was considered with values ≤ 30 ng/mL. Results: In total, 160 women were enrolled: 23 resulted positive for at least one SARS-CoV-2 related test (molecular swab or antibody tests). Vitamin D-associated polymorphisms were able to affect vitamin D levels in SARS-CoV-2 negative and positive subjects: remarkably, all the VDR TaqICC genotype patients were negative for SARS-CoV-2. In a sub-population (118 patients), vitamin D levels correlated with pregnancy-related factors, such as alpha-fetoprotein levels. Third-trimester vitamin D levels were lower in preterm births compared to full-term pregnancy: this trend was highlighted for SARS-CoV-2 positive patients. Conclusions: This is the first study demonstrating a role of vitamin D in affecting the clinical characteristics of pregnant women during the COVID-19 era. Further studies in larger and different cohorts of patients are required to confirm these findings.

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Oxidative stress status and vitamin D levels of asymptomatic to mild symptomatic COVID‐19 infections during the third trimester of pregnancy: A retrospective study in Metz, France

Cited by 14 publications

References 37 publications

Oxidative Stress Biomarkers and Their Association with Mortality among Patients Infected with SARS-CoV-2 in Mexico

Oxidative Stress Biomarkers and Their Association with Mortality among Patients Infected with SARS-CoV-2 in Mexico

The Variable Nature of Vitamin C—Does It Help When Dealing with Coronavirus?

Pregnancy and COVID-19: The Possible Contribution of Vitamin D

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