2008
DOI: 10.2174/156720508786898451
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Oxidative Stress Signaling in Alzheimers Disease

Abstract: Multiple lines of evidence demonstrate that oxidative stress is an early event in Alzheimer’s disease (AD), occurring prior to cytopathology, and therefore may play a key pathogenic role in AD. Oxidative stress not only temporally precedes the pathological lesions of the disease but also activates cell signaling pathways, which, in turn, contribute to lesion formation and, at the same time, provoke cellular responses such as compensatory upregulation of antioxidant enzymes found in vulnerable neurons in AD. In… Show more

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Cited by 260 publications
(214 citation statements)
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References 131 publications
(126 reference statements)
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“…Our findings are in line with recent studies associating A␤ and tau with oxidative stress (17,18,28). Moreover, APP transport was shown to be impaired by elevated tau, suggesting a possible link of the 2 proteins (28,29).…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Our findings are in line with recent studies associating A␤ and tau with oxidative stress (17,18,28). Moreover, APP transport was shown to be impaired by elevated tau, suggesting a possible link of the 2 proteins (28,29).…”
Section: Discussionsupporting
confidence: 93%
“…Energy deficiency and mitochondrial dysfunction have been recognized as a prominent, early event in AD, but the mechanisms leading to mitochondrial failure are not well understood (15,(17)(18)(19)(20)(21)(22)(23)(24). Recently, we had shown in vivo that P301L mutant tau was capable of inducing mitochondrial dysfunction and increasing levels of ROS in pR5 mice (4).…”
Section: Discussionmentioning
confidence: 99%
“…AD is considered as a neurodegenerative disease, however, and multiple pieces of evidence show that oxidative stress may also have a pathogenic role in AD. 51 These results suggest that LPL might have a role in the antioxidation stress of brain through lipids scavenging and recycling, bonding function and other unrecognized mechanisms, and indicate that LPL may be a protective factor of AD. Therefore, dysfunction of antioxidation stress induced by LPL aberration, in the brain, might be a risk factor of AD.…”
Section: Lpl and Ehmentioning
confidence: 75%
“…The reactive oxygen species (ROS) 2 produced play important roles in cell signaling and homeostasis (1), but they also elicit cellular toxicity that causes disease (2)(3)(4). Phagocytes such as macrophages and neutrophils utilize ROS for the digestion of invading bacteria (5,6), where the voltage-gated H ϩ channel (called the Hv channel) optimizes the activity of NADPH oxidase that produces ROS (see Fig.…”
mentioning
confidence: 99%