Oxidative stress: role in pathogenesis of periodontal disease

Vincent, Ruby Ramya; Appukuttan, Devapriya; Prakash, Prem; Victor, Dhayanand John

doi:10.22376/ijpbs.2017.8.3.b1033-1041

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…Diabetes mellitus is well known as a chronic metabolic disease characterized by hyperglycemia that subsequently enhances the hyperinflammation and overproduction of oxidants. The consequences of the exacerbation of inflammatory responses further boost the breakdown of periodontal tissues in individuals suffering from both diabetes and periodontitis [9]. Mechanistically, the impact of ROS on the degradation of periodontal tissues may be attributed to its capacity to oxidize vital biomolecules, such as lipids, proteins, and nucleic acids, as well as to regulate the signal transduction and gene transcription involved in immuno-inflammatory responses and cell death.…”

Section: Oxidants In Periodontal Tissuesmentioning

confidence: 99%

“…The underlying mechanisms are yet to be elucidated. A growing body of evidence has suggested that oxidative stress appears to be the culprit of both local (periodontal in this case) and systemic inflammation [9][10][11]. Oxidative stress represents the increase of oxidants and/or the decrease of antioxidants, leading to the damage of vital cellular components and the destruction of tissues via different paradigms, such as lipid peroxidation and protein inactivation [11].…”

Section: Introductionmentioning

confidence: 99%

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The Promising Role of Antioxidant Phytochemicals in the Prevention and Treatment of Periodontal Disease via the Inhibition of Oxidative Stress Pathways: Updated Insights

Chu

Tuan

et al. 2020

Antioxidants

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There is growing evidence on the involvement of oxidative stress, which is simply described as the imbalance between oxidants and antioxidants in favor of the former, in the development of periodontal disease that is the most common inflammatory disease in the oral cavity. Thus, the potential of antioxidant phytochemicals as adjunctively preventive and therapeutic agents against the initiation and progression of periodontal disease is a topic of great interest. The current review firstly aims to provide updated insights about the immuno-inflammatory pathway regulated by oxidative stress in periodontal pathology. Then, this work further presents the systemic knowledge of antioxidant phytochemicals, particularly the pharmacological activities, which can be utilized in the prevention and treatment of periodontal disease. Additionally, the challenges and future prospects regarding such a scope are figured out.

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Section: Oxidants In Periodontal Tissuesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Promising Role of Antioxidant Phytochemicals in the Prevention and Treatment of Periodontal Disease via the Inhibition of Oxidative Stress Pathways: Updated Insights

Chu

Tuan

et al. 2020

Antioxidants

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“…Antioksidan akan menetralisasi radikal bebas dalam tubuh dengan cara memberikan satu elektronnya sehingga terbentuk molekul yang stabil dan mengakhiri reaksi radikal bebas. 14,36,39 Bioavailabilitas likopen dapat dipengaruhi oleh beberapa faktor, yaitu pecahnya matriks makanan, suhu pemasakan, kehadiran lipid, dosis, dan senyawa larut lainnya termasuk karotenoid lainnya. Beberapa penelitian telah menunjukan bahwa likopen dari tomat atau produk tomat yang diproses secara termal memiliki bioavailabilitas lebih tinggi daripada likopen dari tomat segar, sehingga dapat meningkatkan efektivitas dari likopen.…”

Section: Diskusiunclassified

Pengaruh Mengonsumsi Tomat Ceri (Solanum lycopersicum L. var. cerasiforme) Terhadap Indeks Gingiva

Carolina¹,

Soegiharto²,

Evacuasiany³

2019

sod

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Penyakit periodontal adalah suatu proses peradangan akibat interaksi antara serangan bakteri dan host respon inflamasi. Gingivitis adalah peradangan di dalam jaringan periodonsium yang terbatas pada gingiva. Senyawa yang dapat mengurangi inflamasi dapat ditemukan pada senyawa yang terkandung dalam buah tomat. Likopen adalah salah satu senyawa yang terkandung dalam buah tomat yang memiliki peran antioksidan dan memiliki efek anti-inflamasi. Penelitian ini bertujuan untuk mengetahui pengaruh sesudah mengonsumsi tomat ceri (Solanum lycopersicum L. var. cerasiforme) terhadap indeks gingiva. Penelitian ini menggunakan metode eksperimental semu dengan desain pre dan post test terhadap indeks gingiva yang dilakukan dengan menggunakan metode Modified Gingival Index (MGI). Data yang diukur adalah selisih skor indeks gingiva sebelum dan sesudah mengonsumsi tomat. Subjek penelitian terdiri dari 26 orang. Penelitian dilakukan selama 7 hari dengan 3 kali pemeriksaan yaitu pada hari pertama, hari ke-3, dan hari ke-7. Analisis data indeks gingiva dilakukan dengan menggunakan Wilcoxon sign rank test dan Kruskal-Wallis test. Hasil penelitian rerata indeks gingiva setelah mengonsumsi tomat ceri (Solanum lycopersicum L. var. cerasiforme) pada hari ke-1 sebesar 0.35, pada hari ke-3 sebesar 0.25, dan pada hari ke-7 sebesar 0.12. Hasil analisis data didapatkan nilai p<0.05 yang artinya terdapat perbedaan yang signifikan antara rata-rata indeks gingiva pada hari ke-1, hari ke-3, dan hari ke-7. Simpulan penelitian ini adalah mengonsumsi tomat ceri (Solanum lycopersicum L. var. cerasiforme) dapat menurunkan indeks gingiva.

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“…During inflammation, the polymorph nuclear leukocytes make reactive oxygen species (ROS) which are very disastrous to the tissue. The damage caused by these ROS is removed or repaired by antioxidants (AO) (3) .…”

Section: Introductionmentioning

confidence: 99%

“…Figure(3) shows the action of TiO2 NPs (µg/ml) on the peroxidase activity (U/L) in the reaction mix of a total volume of ( 3020). It was established that TiO2 NPs at a concentration of 0.79 µg/ml have a higher activation effect on the enzyme activity in the mixture.…”

mentioning

confidence: 99%

The Effect of titanium dioxide nanoparticles on the activity of salivary peroxidase in periodontitis patients

et al. 2023

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Background:The technology of nanoparticles has been expanded to many aspects of modern life. Titanium dioxide nanoparticles were of many nanomaterials utilized in biomedical applications. The interactions between nanoparticles and proteins are believed to be the base for the biological effect of the nanoparticles. The oxidation reaction of many substances is catalyzed by oxidizing enzymes called peroxidases. The activity of salivary peroxidase is elevated with periodontal diseases. the aim ofthis study is to examine the action of titanium dioxide nanoparticles on salivary peroxidase activity.Material and method75 participants were enrolled in this study—Periodontitis group with 44 participants and the non-periodontitis group with 31 participants. The participants' age range was 35 to 50 years for both groups. The clinical parameters of plaque index, gingival index, probing pocket depth and clinical attachment level were used in this study to determine the presence or absence of the periodontal disease. Unstimulated saliva was collected from all participants and analyzed for the activity of peroxidase enzyme under the effect of titanium dioxide nanoparticles. ResultsThe Periodontitis group showed higher peroxidase enzyme activity than the non-periodontitis group and the activity of salivary peroxidase showed no correlation with the clinical parameters. Titanium dioxide nanoparticles increased salivary peroxidase activity. ConclusionThis study demonstrated that the solid surface of nanoparticles could induce changes in the attached protein molecule which in turn causes changes in the effect of the nanoparticles on living tissue or organism. The titanium dioxide nanoparticles Play a role in increasing the activity of salivary peroxidase within the saliva of chronic periodontitis patients.

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Oxidative stress: role in pathogenesis of periodontal disease

Cited by 5 publications

References 30 publications

The Promising Role of Antioxidant Phytochemicals in the Prevention and Treatment of Periodontal Disease via the Inhibition of Oxidative Stress Pathways: Updated Insights

The Promising Role of Antioxidant Phytochemicals in the Prevention and Treatment of Periodontal Disease via the Inhibition of Oxidative Stress Pathways: Updated Insights

Pengaruh Mengonsumsi Tomat Ceri (Solanum lycopersicum L. var. cerasiforme) Terhadap Indeks Gingiva

The Effect of titanium dioxide nanoparticles on the activity of salivary peroxidase in periodontitis patients

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