Oxidative stress response to acute hypobaric hypoxia and its association with indirect measurement of increased intracranial pressure: a field study

Abstract

High altitude is the most intriguing natural laboratory to study human physiological response to hypoxic conditions. In this study, we investigated changes in reactive oxygen species (ROS) and oxidative stress biomarkers during exposure to hypobaric hypoxia in 16 lowlanders. Moreover, we looked at the potential relationship between ROS related cellular damage and optic nerve sheath diameter (ONSD) as an indirect measurement of intracranial pressure. Baseline measurement of clinical signs and symptoms, biological samples and ultrasonography were assessed at 262 m and after passive ascent to 3830 m (9, 24 and 72 h). After 24 h the imbalance between ROS production (+141%) and scavenging (−41%) reflected an increase in oxidative stress related damage of 50–85%. ONSD concurrently increased, but regression analysis did not infer a causal relationship between oxidative stress biomarkers and changes in ONSD. These results provide new insight regarding ROS homeostasis and potential pathophysiological mechanisms of acute exposure to hypobaric hypoxia, plus other disease states associated with oxidative-stress damage as a result of tissue hypoxia.

Bedside Ultrasonography as an Alternative to Computed Tomography Scan for the Measurement of Optic Nerve Sheath Diameter

“…first described the role of ONSD in high-altitude illnesses,[ 7 ] there have been only six studies till date on the subject. [ 5 12 13 14 15 16 ] The investigators in these studies have used various measurement techniques, with no consensus on the best method of measurement of ONSD.…”

Обоснование И Клиническая Эффективность Коррекции Гомеостаза Цинка В Интенсивной Терапии Острой Церебральной Недостаточности

“…Відомо про вплив цього засобу не лише на оксидативний стрес, але й на викликане ним церебральне ураження [22,23]. Таким чином, рівень НСЄ не лише відбиває силу нейронального ушкодження, а й може слугувати маркером оксидативного ураження мозку [24,25]. The main group (n = 47) included the patients who had additionally prescribed zinc sulfate monohydrate and acetylcysteine for up to 7 days; the comparison group (n = 47) included the patients undergone the traditional treatment management.…”

Compound Danshen Dropping Pills Enhanced Erythrocyte Oxygen Delivery Capacity via Modulating ROS-Dependent Mechanism Based on Target-Network Analysis

“…First of all, we collected and integrated the targets of CDDP, which were divided into literature data set and experimental data set ( In high altitudes, healthy residents are exposed to low pressure and hypoxia, and their heart rate gradually increases. Oxidative stress biomarkers such as ROS in the body dramatically increase within 24 hours [9], leading to oxidative damage of proteins and DNA to some extent [10]. Moreover, accumulating ROS will oxidize ferrous hemoglobin and ferric hemoglobin, which play key roles in oxygen delivery in erythrocyte, into methyl hemoglobin and tetravalent iron (ferrum) hemoglobin [12], respectively, disabling them to carry oxygen.…”

“…Studies show that the production of ROS and other oxidative stress biomarkers increase a lot in AMS patients because of hypoxia [9,10]. The accumulated ROS leads to the reduction of red blood cell oxygen delivery capacity, as well as aging and inflammatory damage of erythrocyte and vascular endothelial cells, which seriously jeopardize oxygen transport capacity of arterial blood and cause a series of pathophysiological reactions such as tissue hypoxic damage consequently.…”