Oxidative stress response pathways in fungi

Yaakoub, Hajar; Mina, Sara; Calenda, Alphonse; Bouchara, Jean-Philippe; Papon, Nicolas

doi:10.1007/s00018-022-04353-8

Cited by 34 publications

(7 citation statements)

References 320 publications

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“…The reduced glutathione GSH and oxidized glutathione GSSG are important components of the glutathione system that maintains redox homeostasis. 41 The ratio of GSH/GSSG directly reflects the redox state mediated by the glutathione reductase system. 42 In this study, the GSH content decreased and GSSG content slightly increased after the P852 treatment, and the ratio of GSH/GSSG had significantly decreased after 12 h of treatment (p < 0.05).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…It also indicated that the degree of membrane peroxidation was more drastic with the prolongation of the treatment time. The reduced glutathione GSH and oxidized glutathione GSSG are important components of the glutathione system that maintains redox homeostasis . The ratio of GSH/GSSG directly reflects the redox state mediated by the glutathione reductase system .…”

Section: Resultsmentioning

confidence: 99%

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Antifungal Peptide P852 Effectively Controls Fusarium oxysporum, a Wilt-Causing Fungus, by Affecting the Glucose Metabolism and Amino Acid Metabolism as well as Damaging Mitochondrial Function

Wang,

Yao,

Chen

et al. 2023

J. Agric. Food Chem.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Antifungal Peptide P852 Effectively Controls Fusarium oxysporum, a Wilt-Causing Fungus, by Affecting the Glucose Metabolism and Amino Acid Metabolism as well as Damaging Mitochondrial Function

Wang,

Yao,

Chen

et al. 2023

J. Agric. Food Chem.

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“…Hog1 is a MAPK widely conserved in fungi 16,47 . In fungi such as S. cerevisiae and C. neoformans, the Hog1-mediated signaling pathway is involved in the resistance to various stressors 15,16 .…”

Section: Discussionmentioning

confidence: 99%

Hog1-mediated stress tolerance in the pathogenic fungus Trichosporon asahii

Matsumoto

Nagamachi

et al. 2023

Preprint

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Trichosporon asahii is a conditional pathogenic fungus that causes severe and sometimes fatal infections in immunocompromised patients.Hog1, a mitogen-activated protein kinase, is known to regulate the stress resistance of some pathogenic fungi, but its role in T. asahii has not been investigated. Here, we demonstrated that the hog1 gene-deficient T. asahii mutant is sensitive to high temperature, cell-membrane stress, oxidative stress, and antifungal drugs. The growth of the hog1 gene-deficient T. asahii mutant was delayed at 40˚C. The hog1 gene-deficient T. asahii mutant also exhibited sensitivity to sodium dodecyl sulfate, hydrogen peroxide, menadione, methyl methanesulfonate, UV exposure, and antifungal drugs such as amphotericin B under a glucose-rich condition. Under a glucose-restricted condition, the hog1 gene-deficient mutant exhibited sensitivity to NaCl and KCl. The virulence of the hog1gene-deficient mutant against silkworms was attenuated. Moreover, the cell viability of the hog1 gene-deficient mutant was decreased in the silkworm hemolymph. These phenotypes were restored by re-introducing the hog1 gene into the gene-deficient mutant. Our findings suggest that Hog1 has a critical role in regulating the cellular stress responses of T. asahii.

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“…The antioxidant defense against oxidative stress in fungi as well as other eukaryotes is a network of enzymatic superoxide dismutase, catalases, and the thioredoxin system. The fungal response to oxidative stress is therefore complex and necessitates the collaborative involvement of cognate regulators such as the HOG pathway, Yap1, and Skn7 [ 33 ]. Nonenzymatic radical-scavenging secondary metabolites have overlapping roles in intercepting ROS and in turning over the cellular buffer of reductants.…”

Section: Discussionmentioning

confidence: 99%

Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii

et al. 2022

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The new polyketides lopouzanones A and B, as well as the new 1-O-acetyl and 2-O-acetyl derivatives of dendrodochol B, were isolated from the sponge-derived marine fungus Lopadostoma pouzarii strain 168CLC-57.3. Moreover, six known polyketides, gliorosein, balticolid, dendrodolide G, dihydroisocoumarine, (–)-5-methylmellein, and dendrodochol B, were identified. The structures of the isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of the lopouzanones A and B were determined using the Mosher’s method. The cytotoxicity of the isolated compounds against human prostate cancer cells PC-3 and normal rat cardiomyocytes H9c2 was investigated. Gliorosein showed weak DPPH radical-scavenging activity and in vitro cardioprotective effects toward rotenone toxicity and CoCl2-mimic hypoxia.

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Oxidative stress response pathways in fungi

Cited by 34 publications

References 320 publications

Antifungal Peptide P852 Effectively Controls Fusarium oxysporum, a Wilt-Causing Fungus, by Affecting the Glucose Metabolism and Amino Acid Metabolism as well as Damaging Mitochondrial Function

Antifungal Peptide P852 Effectively Controls Fusarium oxysporum, a Wilt-Causing Fungus, by Affecting the Glucose Metabolism and Amino Acid Metabolism as well as Damaging Mitochondrial Function

Hog1-mediated stress tolerance in the pathogenic fungus Trichosporon asahii

Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii

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