Oxidative stress-related mitochondrial dysfunction as a possible reason for obese male infertility

Lü, Yan; Zhao, Donghai; Yu, Haitao; Zheng, L; Xü, Ying; Wen, Haiyan; Dai, Xuemei; Wang, Shuran

doi:10.1016/j.nupar.2020.02.438

Cited by 2 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All these specific events are closely interconnected and strictly rely on a normal physiological status of gonads and gametes and involve different hormones. The hormonal control systems of reproduction are dynamic processes, which are vulnerable to several sources of physiological stress caused by microenvironmental disturbs [8]. A large amount of studies reveals that a healthy status of parents is an essential prerequisite to achieve successful fertilization.…”

Section: Introductionmentioning

confidence: 99%

Reprotoxic Impact of Environment, Diet, and Behavior

Gallo

2022

IJERPH

View full text Add to dashboard Cite

Reproductive health is progressively declining due to multiples endogenous and exogenous factors, such as environmental contaminants, diet and behavior. Accumulated evidences confirm that fertility and reproductive function have been adversely affected by exposure to chemical contaminants released in the environment. Today, the impact of diet and behavior on reproductive processes is also receiving special attention from the scientific community. Indeed, a close relationship between diet and fertility has been proven. Furthermore, a combination of unhealthy behavior, such as exposure to hazardous compounds and stress factors, poses living organisms at higher risk of reprotoxic effects. In particular, it has been described that poor life behaviors are associated with reduced male and female fertility due to decreased gamete quality and function. Most of the erroneous behaviors are, furthermore, a source of oxidative stress that, leading to epigenetic alterations, results in an impaired reproductive fitness. This review reports the detrimental impact of the most common environmental chemical stressors, diet, and behavior on reproductive functionality and success. Although clear evidences are still scarce, reassuring data are provided that a healthy diet and reverting unhealthy lifestyles may be of help to recover physiological reproductive conditions.

show abstract

Section: Introductionmentioning

confidence: 99%

Reprotoxic Impact of Environment, Diet, and Behavior

Gallo

2022

IJERPH

View full text Add to dashboard Cite

show abstract

Sperm Mitochondria, the Driving Force Behind Human Spermatozoa Activities: Its Functions and Dysfunctions - A Narrative Review

Kumar

2023

CMM

View full text Add to dashboard Cite

Male infertility is a major issue and numerous factors contribute to it. One of the important organelles involved in the functioning of human spermatozoa is mitochondria. There are 50-75 mitochondria helically arranged in mid-piece bearing one mitochondrial DNA each. Sperm mitochondria play a crucial role in sperm functions including the energy production required for sperm motility, production of reactive oxygen species which in the physiological range helps in sperm maturation, capacitation, and acrosome reaction. It also plays a role in calcium signaling cascades, intrinsic apoptosis, sperm hyperactivation. Any structural or functional dysfunction of sperm mitochondria results in increased production of reactive oxygen species and a state of oxidative stress, decreased energy production, all leading to sperm DNA damage, impaired sperm motility and semen parameters, and reduced male fertility. Furthermore, human sperm mitochondrial DNA mutations can result in impaired sperm motility and parameters leading to male infertility. Numerous types of point mutations, deletions, missense mutations have been identified in mtDNA that are linked with male infertility. Methods: Recent literature was searched from English language peer-reviewed journals from databases including PubMed, Scopus, EMBASE, Scholar, Web of Science till September 2021. Search terms used were “Sperm mitochondria and male fertility”; “Bioenergetics of sperm”; “Sperm mitochondria and reactive oxygen species”, “Sperm mitochondrial mutations and infertility”. Conclusion: Sperm mitochondria is an important organelle involved in various functions of human spermatozoa and sperm mitochondrial DNA, has emerged as one of the potent biomarkers of sperm quality and male fertility.

show abstract

Oxidative stress-related mitochondrial dysfunction as a possible reason for obese male infertility

Cited by 2 publications

References 37 publications

Reprotoxic Impact of Environment, Diet, and Behavior

Reprotoxic Impact of Environment, Diet, and Behavior

Sperm Mitochondria, the Driving Force Behind Human Spermatozoa Activities: Its Functions and Dysfunctions - A Narrative Review

Contact Info

Product

Resources

About