Oxidative Stress, Plant Natural Antioxidants, and Obesity

Pérez-Torres, Israel; Castrejón-Téllez, Vicente; Soto, María Elena; Rubio-Ruiz, María Esther; Manzano-Pech, Linaloe; Guarner-Lans, Verónica

doi:10.3390/ijms22041786

Cited by 173 publications

(87 citation statements)

References 215 publications

(261 reference statements)

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“…The aim of this study is to perform a comparative analysis of five UBDE obtained using different solvents. We highlighted their phytochemical profile determining the content of usnic acid [ 26 ], polyphenols [ 27 ], tannins [ 28 ], and polysaccharides [ 29 ]—all these classes of organic compounds being recognized due to their antioxidant properties. The antioxidant activity of UBDE was evaluated and correlated with UAC, TPC, and TC.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Cytotoxic Activities of Usnea barbata (L.) F.H. Wigg. Dry Extracts in Different Solvents

Popovici

Bucur

Popescu

et al. 2021

Plants

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Lichens represent a significant source of antioxidants due to numerous metabolites that can reduce free radicals. Usnea barbata (L.) F.H. Wigg. has been recognized and used since ancient times for its therapeutic effects, some of which are based on its antioxidant properties. The present study aims to analyze the phytochemical profile and to evaluate the antioxidant and cytotoxic potential of this lichen species. Five dry extracts of U. barbata (UBDE) in different solvents (acetone, ethyl acetate, ethanol, methanol, water) were prepared by refluxing at Soxhlet to achieve these proposed objectives and to identify which solvent is the most effective for the extraction. The usnic acid content (UAC) was quantified by ultra-high performance liquid chromatography (UHPLC). The total polyphenols content (TPC) and tannins content (TC) were evaluated by spectrophotometry, and the total polysaccharides (PSC) were extracted by a gravimetric method. The 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) free radical method was used to assess the antioxidant activity (AA) and the Brine Shrimp Lethality (BSL) assay was the biotest for cytotoxic activity evaluation. The ethyl acetate extract had the highest usnic acid content, and acetone extract had the highest content of total polyphenols and tannins. The most significant antioxidant effect was reported to methanol extract, and all the extracts proved high cytotoxicity. The water extract has the lowest cytotoxicity because usnic acid is slightly soluble in this solvent, and it was not found at UHPLC analysis. All extracts recorded a moderate correlation between the content of usnic acid, polyphenols, tannins, and AA; furthermore, it has been observed that the cytotoxicity varies inversely with the antioxidant effect.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and Cytotoxic Activities of Usnea barbata (L.) F.H. Wigg. Dry Extracts in Different Solvents

Popovici

Bucur

Popescu

et al. 2021

Plants

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“…Natural flavonoids have gained increasing recognition in recent years for their health-related activities, such as their potential antioxidant, antitumor, and anti-inflammatory, antimicrobial, and antifungal properties [ 15 , 16 , 17 , 18 , 19 , 20 ]. Several reports describe flavonoid potential to be used as drugs and nutraceutical compounds.…”

Section: Introductionmentioning

confidence: 99%

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

et al. 2021

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Flavonoids are among the most abundant natural bioactive compounds produced by plants. Many different activities have been reported for these secondary metabolites against numerous cells and systems. One of the most interesting is certainly the antimicrobial, which is stimulated through various molecular mechanisms. In fact, flavonoids are effective both in directly damaging the envelope of Gram-negative and Gram-positive bacteria but also by acting toward specific molecular targets essential for the survival of these microorganisms. The purpose of this paper is to present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins. Despite the great structural heterogeneity of these plant metabolites, it is interesting to observe that many flavonoids affect the same cellular pathways. Furthermore, it is evident that some of these compounds interact with more than one target, producing multiple effects. Taken together, the reported data demonstrate the great potential of flavonoids in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.

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“…Inhibition of SOD increases vascular OS and alters the endothelium-dependent vasoreactivity [48]. In mice lacking an isoform of SOD such as the extracellular isoform, there are increased amounts of ROS and alterations in vascular reactivity [49]. Down-regulation of SOD-Mn in MS rats and the subsequent excessive release of O 2 − and H 2 O 2 contribute to the inflammatory, proliferative, and fibrotic renal injury.…”

Section: Oxidant/antioxidant Effect Of the Hsl Infusionmentioning

confidence: 99%

Modulation of Renal Function in a Metabolic Syndrome Rat Model by Antioxidants in Hibiscus sabdariffa L.

et al. 2021

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Metabolic syndrome (MS) is the association of three or more pathologies among which obesity, hypertension, insulin resistance, dyslipidemia, and diabetes are included. It causes oxidative stress (OS) and renal dysfunction. Hibiscus sabdariffa L. (HSL) is a source of natural antioxidants that may control the renal damage caused by the MS. The objective of this work was to evaluate the effect of a 2% HSL infusion on renal function in a MS rat model induced by the administration of 30% sucrose in drinking water. 24 male Wistar rats were divided into 3 groups: Control rats, MS rats and MS + HSL rats. MS rats had increased body weight, systolic blood pressure, triglycerides, insulin, HOMA index, and leptin (p ≤ 0.04). Renal function was impaired by an increase in perfusion pressure in the isolated and perfused kidney, albuminuria (p ≤ 0.03), and by a decrease in clearance of creatinine (p ≤ 0.04). The activity of some antioxidant enzymes including the superoxide dismutase isoforms, peroxidases, glutathione peroxidase, glutathione-S-transferase was decreased (p ≤ 0.05). Lipoperoxidation and carbonylation were increased (p ≤ 0.001). The nitrates/nitrites ratio, total antioxidant capacity, glutathione levels and vitamin C were decreased (p ≤ 0.03). The treatment with 2% HSL reversed these alterations. The results suggest that the treatment with 2% HSL infusion protects renal function through its natural antioxidants which favor an improved renal vascular response. The infusion contributes to the increase in the glomerular filtration rate, by promoting an increase in the enzymatic and non-enzymatic antioxidant systems leading to a decrease in OS and reestablishing the normal renal function.

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Oxidative Stress, Plant Natural Antioxidants, and Obesity

Cited by 173 publications

References 215 publications

Antioxidant and Cytotoxic Activities of Usnea barbata (L.) F.H. Wigg. Dry Extracts in Different Solvents

Antioxidant and Cytotoxic Activities of Usnea barbata (L.) F.H. Wigg. Dry Extracts in Different Solvents

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

Modulation of Renal Function in a Metabolic Syndrome Rat Model by Antioxidants in Hibiscus sabdariffa L.

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