Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid

Perluigi, Marzia; Domenico, Fabio Di; Fiorini, Ada; Cocciolo, Annalisa; Giorgi, Alessandra; Foppoli, Cesira; Butterfield, D. Allan; Giorlandino, Maurizio; Giorlandino, Claudio; Schininà, Maria Eugenia; Coccia, Raffaella

doi:10.1002/prca.201000121

Cited by 90 publications

(83 citation statements)

References 71 publications

(69 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By a redox proteomics approach, we identified selective proteins that showed increased oxidation in DS fetuses compared with healthy controls. Our results demonstrated that oxidative stress is an early event in the pathogenesis of DS (147).…”

Section: Down Syndromesupporting

confidence: 59%

4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies

Perluigi

Coccia

Butterfield

2012

Antioxidants & Redox Signaling

Self Cite

185

133

View full text Add to dashboard Cite

Significance: Among different forms of oxidative stress, lipid peroxidation comprises the interaction of free radicals with polyunsaturated fatty acids, which in turn leads to the formation of highly reactive electrophilic aldehydes. Among these, the most abundant aldehydes are 4-hydroxy-2-nonenal (HNE) and malondialdehyde, while acrolein is the most reactive. HNE is considered a robust marker of oxidative stress and a toxic compound for several cell types. Proteins are particularly susceptible to modification caused by HNE, and adduct formation plays a critical role in multiple cellular processes. Recent Advances: With the outstanding progress of proteomics, the identification of putative biomarkers for neurodegenerative disorders has been the main focus of several studies and will continue to be a difficult task. Critical Issues: The present review focuses on the role of lipid peroxidation, particularly of HNE-induced protein modification, in neurodegenerative diseases. By comparing results obtained in different neurodegenerative diseases, it may be possible to identify both similarities and specific differences in addition to better characterize selective neurodegenerative phenomena associated with protein dysfunction. Results obtained in our laboratory and others support the common deregulation of energy metabolism and mitochondrial function in neurodegeneration. Future Directions: Research towards a better understanding of the molecular mechanisms involved in neurodegeneration together with identification of specific targets of oxidative damage is urgently required. Redox proteomics will contribute to broaden the knowledge in regard to potential biomarkers for disease diagnosis and may also provide insight into damaged metabolic networks and potential targets for modulation of disease progression. Antioxid. Redox Signal. 17, 1590-1609.

show abstract

Section: Down Syndromesupporting

confidence: 59%

4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies

Perluigi

Coccia

Butterfield

2012

Antioxidants & Redox Signaling

Self Cite

185

133

View full text Add to dashboard Cite

show abstract

“…We found increased levels of OS, as indexed by increased protein oxidation, lipid peroxidation, reduction of glutathione and thioredoxin levels and induction of the heat-shock response [19]. Other investigators have also reported increased levels of isoprostanes in second trimester amniotic fluid samples from DS fetuses [20].…”

Section: Is Os the Bridge Between Ds And Alzheimer's Disease?supporting

confidence: 54%

The identification of protein biomarkers for oxidative stress in Down syndrome

Perluigi

Butterfield²

2011

Expert Review of Proteomics

Self Cite

View full text Add to dashboard Cite

“…Increase in SOD, TBARS and catalase in people with DS supports the use of AO therapy [65]. Increased OS in DS was indicated by rise in protein oxidation and lipid peroxidation with reduction in GSH [66]. The oxidative damage is an early event.…”

Section: Down's Syndrome (Ds)mentioning

confidence: 84%

Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species

Kovacic¹,

Somanathan²

2012

Current Neuropharmacology

View full text Add to dashboard Cite

Much attention has been devoted to neurodegenerative diseases involving redox processes. This review comprises an update involving redox processes reported in the considerable literature in recent years. The mechanism involves reactive oxygen species and oxidative stress, usually in the brain. There are many examples including Parkinson's, Huntington's, Alzheimer's, prions, Down's syndrome, ataxia, multiple sclerosis, Creutzfeldt-Jacob disease, amyotrophic lateral sclerosis, schizophrenia, and Tardive Dyskinesia. Evidence indicates a protective role for antioxidants, which may have clinical implications. A multifaceted approach to mode of action appears reasonable.

show abstract

Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid

Abstract: Our results indicate that oxidative damage is an early event in the DS pathogenesis and might contribute to the development of deleterious DS phenotypes, including abnormal development and AD-like neuropathology.

Cited by 90 publications

References 71 publications

4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies

4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies

The identification of protein biomarkers for oxidative stress in Down syndrome

Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species

Contact Info

Product

Resources

About