Oxidative stress: Normal pregnancy versus preeclampsia

Chiarello, Delia I.; Abad, Cilia; Rojas, Deliana; Toledo, Fernando; Vázquez, Carmen M.; Mate, Alfonso; Sobrevía, Luis; Marı́n, Reinaldo

doi:10.1016/j.bbadis.2018.12.005

Cited by 188 publications

(111 citation statements)

References 214 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…Placentas from women with PE develop in prolonged hypoxic state that extends beyond the physiological period in the first trimester [20,22]. Additionally, during PE, the placenta is exposed to excessive oxidative stress and inflammation, accompanied by abnormal trophoblast differentiation and increased secretion of anti-angiogenic proteins compared to healthy control patients [23][24][25]. Inflammation and oxidative stress conditions can increase NFκB activity and without coincidence, multiple reports show that women with PE exhibit up to 10-fold increase in NFκB expression in the placenta and maternal circulation compared to control pregnancies [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight

Armistead

Kadam

Drewlo

et al. 2020

IJMS

View full text Add to dashboard Cite

The NFκB protein family regulates numerous pathways within the cell—including inflammation, hypoxia, angiogenesis and oxidative stress—all of which are implicated in placental development. The placenta is a critical organ that develops during pregnancy that primarily functions to supply and transport the nutrients required for fetal growth and development. Abnormal placental development can be observed in numerous disorders during pregnancy, including fetal growth restriction, miscarriage, and preeclampsia (PE). NFκB is highly expressed in the placentas of women with PE, however its contributions to the syndrome are not fully understood. In this review we discuss the molecular actions and related pathways of NFκB in the placenta and highlight areas of research that need attention

show abstract

Section: Introductionmentioning

confidence: 99%

The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight

Armistead

Kadam

Drewlo

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Accumulated evidence suggests a tight association between chronic stress and psychiatric disorders [ 17 – 21 ]. Especially severe, prolonged and/or chronic stress of any origin such as exercise-induced oxidative stress [ 22 ] (see “ Physical activity and exercise-induced oxidative stress ” section), hormonal stress [ 23 ], emotional stress and psychological burden [ 24 – 27 ] as well as metabolic stress, e.g. in diabetes mellitus [ 28 , 29 ] (see also below “ Association between diabetes mellitus and carcinogenesis: diagnostic and therapeutic potential of cell-free nucleic acids ” section) and hyperhomocysteinaemia [ 30 , 31 ] amongst others, is associated with highly increased ROS production and insufficient repair capacity—both linked to oxidative damage of mitochondria and consequent mitochondrial dysfunction leading to the development of cardiovascular impairments [ 32 – 34 ], neuro/degenerative pathologies [ 34 – 37 ], impaired healing [ 34 ] and malignant cell transformation [ 34 , 38 – 42 ].…”

Section: Diagnostic and Prognostic Potential Of Cell-free Nucleic Acimentioning

confidence: 99%

“…Regular physical activity defined as movements of body mediated by skeletal muscles resulted in the energy expenditure usually measured in kilocalories [ 57 ] has been demonstrated as being crucial for physical and mental health benefits [ 58 ], prevention of various diseases including metabolic syndrome, obesity, insulin resistance, atherosclerosis, diabetes, neurodegenerative diseases and cancers [ 23 – 27 ]. Regular individually adapted exercise has an ability to inhibit ROS production, ameliorates the antioxidant capacity and improves mitochondria efficiency reducing oxidative stress and cellular damage [ 59 ].…”

Section: Physical Activity and Exercise-induced Oxidative Stressmentioning

confidence: 99%

Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope?

et al. 2020

View full text Add to dashboard Cite

Interest in the use of cell-free nucleic acids (CFNAs) as clinical non-invasive biomarker panels for prediction and prevention of multiple diseases has greatly increased over the last decade. Indeed, circulating CFNAs are attributable to many physiological and pathological processes such as imbalanced stress conditions, physical activities, extensive apoptosis of different origin, systemic hypoxic-ischemic events and tumour progression, amongst others. This article highlights the involvement of circulating CFNAs in local and systemic processes dealing with the question, whether specific patterns of CFNAs in blood, their detection, quantity and quality (such as their methylation status) might be instrumental to predict a disease development/progression and could be further utilised for accompanying diagnostics, targeted prevention, creation of individualised therapy algorithms, therapy monitoring and prognosis. Presented considerations conform with principles of 3P medicine and serve for improving individual outcomes and cost efficacy of medical services provided to the population.

show abstract

“…Sedangkan pada umur 35 tahun atau lebih, dimana pada umur tersebut terjadi perubahan pada jaringan dan alat kandungan serta jalan lahir tidak lentur lagi. 10,[16][17][18] Dari hasil penelitian karakteristik hipertensi dalam kehamilan berdasarkan gravida didapatkan kejadian preeklamsi ringan tinggi pada kehamilan multigravida. Sedangkan beberapa studi menghasilkan fakta-fakta yang menunjukkan bahwa faktor imunologik turut berperan terhadap hipertensi dalam kehamilan.…”

Section: Pendahuluanunclassified

Untitled

Pranamartha

Sukadana

Sudiarta

2019

Obgynia

View full text Add to dashboard Cite

Untuk mengetahui karakteristik pasien hipertensi pada kehamilan di RSUD Klungkung tahun 2017. Metode: Penelitian ini merupakan penelitian cros-sectional deskriptif yang dilakukan di unit bersalin RSUD Klungkung selama periode Januari hingga April 2017. Analisis data dilakukan secara deskriptif Hasil: Kejadian hipertensi pada kehamilan lebih banyak terjadi pada ibu usia 20-24 tahun, didapatkan kejadian preeklamsia ringan tinggi pada kehamilan multigravida, kejadian preeklamsi berat cukup tinggi pada usia kehamilan preterm, kejadian preeklamsi ringan tinggi pada ibu dengan BMI kriteria overweight, persalinan sectio cesaria cukup tinggi pada ibu hamil dengan preeklamsi berat, terdapat kejadian bayi lahir mati sebanyak 3 bayi pada ibu dengan preeklamsi berat. Pembahasan: Hipertensi pada kehamilan sangat dipengaruhi oleh banyak faktor selain dari pada faktor karakteristik itu sendiri, faktor imunologi juga memiliki peranan penting terhadap terjadinya hipertensi pada kehamilan. Kesimpulan: Kejadian preeklamsi ringan masih mendominasi dari keseluruhan kasus hipertensi pada kehamilan, kemudian luaran klinis bayi lahir mati cederung terjadi pada kasus preeklamsi berat.

show abstract

Oxidative stress: Normal pregnancy versus preeclampsia

Cited by 188 publications

References 214 publications

The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight

The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight

Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope?

Untitled

Contact Info

Product

Resources

About