Oxidative stress mediates apoptosis induced by oxidized low-density lipoprotein and oxidized lipoprotein(a)

Heermeier, Kathrin; Schneider, Reinhard; Heinloth, Alexandra N.; Wanner, Christoph; Dimmeler, Stefanie; Galle, Jan

doi:10.1046/j.1523-1755.1999.00685.x

Cited by 30 publications

(20 citation statements)

References 18 publications

(7 reference statements)

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“…The mechanisms through which statins might affect endothelial cell apoptosis are the confinement of inflammation, the increase in the bioavailability of nitric oxide and their anti-oxidative effects. 14,15 It is interesting that the effects of both treatments on the markers of inflammation, oxLDL as well as lipids, lasted for no more than 3 months, since during the washout period they returned to baseline levels. We believe that this finding reflects the active and ongoing inflammatory and oxidative mechanisms working in these patients and signifies the need for a continuous intervention in order to suppress these atherogenic mechanisms.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Vitamin E-Coated Membrane Dialyzer Compared to Simvastatin in Patients on Chronic Hemodialysis

et al. 2012

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Background: We investigated the effects of the use of vitamin E-coated membrane (VEM) dialyzer in comparison to simvastatin on markers of chronic inflammation, oxidative stress, and endothelial cell apoptosis in ten patients on chronic hemodialysis (HD), aiming at distinguishing the different treatment effects and their time sequence on these pathogenetic routes. Methods: Ten HD patients were sequentially submitted to a 6-month treatment with the use of VEM and 10 mg of simvastatin daily, interrupted by a 3-month washout period. At baseline, at 3, and 6 months of each trial, serum C-reactive protein (CRP), apolipoprotein (Apo) A1 and B, lipoprotein-a [Lp(a)], high-sensitivity interleukin-6 (hsIL-6), monocyte chemoattractant protein-1 (MCP-1), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin (sE-selectin), soluble Fas (sFas), soluble Fas ligand (sFasL), and plasma oxidized low-density lipoproteins (oxLDL) levels were determined. Results: VEM treatment resulted in a significant decrease in CRP, IL-6, sICAM-1 at 3 months, and oxLDL at 6 months, compared to baseline. Simvastatin resulted in a significant decrease in CRP, which correlated with decreases in both total (r ¼ 0.87, p < 0.05) and low-density lipoprotein cholesterol, IL-6, sICAM-1, sVCAM-1, oxLDL, and sFas at 6 months, compared to baseline. Simvastatin effects on sVCAM-1 (mean difference ¼ 652 ng/mL; 95% CI ¼ 294 to 2686; p < 0.05) and sFas (mean difference ¼ 1284 pg/mL; 95% CI ¼ 510 to 1910; p < 0.05) differed significantly from the corresponding VEM effects. Conclusions: The 6-month use of VEM resulted in more direct and immediate anti-inflammatory effects compared with those caused by the 6-month treatment with simvastatin. Simvastatin caused a more intense decrease in the markers of inflammation, which was in part correlated with its lipid-lowering effects.

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Section: Discussionmentioning

confidence: 99%

The Effects of Vitamin E-Coated Membrane Dialyzer Compared to Simvastatin in Patients on Chronic Hemodialysis

et al. 2012

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“…Inhibitors of apoptosis relevant to atherosclerosis include shear stress, 33 growth factors, 13,75 antioxidant drugs or enzymes (eg, superoxide dismutase [SOD]), 76 and pharmacological doses of certain antioxidant vitamins 77 ( Table 2). By counteracting the apoptotic effects of cytotoxic factors, these inhibitors may maintain the integrity of the endothelium and increase the cellularity of the vessel wall.…”

Section: Antiapoptotic Factors In Atherosclerosismentioning

confidence: 99%

Progression of Atheroma

Geng

Libby

2002

ATVB

250

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Abstract-Traditional thinking accorded a major role to deranged cell proliferation as a determinant of the abnormal cellularity of atheroma. However, studies conducted in several laboratories have documented the occurrence of disordered apoptosis during atherogenesis, leading to the death of lipid-rich foam cells (promoting lipid-core formation) and depletion of vascular smooth muscle cells (fostering fragility of the fibrous cap). A complex interplay of environmental factors and endogenous proteins regulates apoptosis and contributes to the struggle between cell death and procreation in atherosclerosis. In addition to a variety of growth factors, chemically modified lipids, reactive oxygen species, proinflammatory cytokines, and Fas ligand produced by activated immune cells may influence cell viability through a diversity of pathways, including the caspase cascade, the Bcl-2 protein family, and the oncogene/antioncogene system. A clarification of the molecular mechanisms responsible for vascular cell death may aid in the development of novel therapeutic strategies to treat atherosclerosis and its complications, including the acute coronary syndromes.

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“…Inhibitors of apoptosis relevant to atherosclerosis include shear stress [141], growth factors, [142,143] antioxidant drugs or enzymes (e.g., superoxide dismutase [SOD]) [143], and pharmacological doses of certain antioxidant vitamins [144]. PDGF protects SMCs from apoptosis [145,146].…”

Section: Apoptosis Inhibitorsmentioning

confidence: 99%

Cytokines and growth factors involved in apoptosis and proliferation of vascular smooth muscle cells

Rakesh

Agrawal

2005

International Immunopharmacology

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Oxidative stress mediates apoptosis induced by oxidized low-density lipoprotein and oxidized lipoprotein(a)

Abstract: We measured oxidative stress caused by lipoproteins in human umbilical vein endothelial cells and rabbit aorta. Oxidized lipoprotein(a) was the more potent stimulus over oxidized low density lipoprotein, and we believe that both influence the pathogenesis of atherosclerosis.

Cited by 30 publications

References 18 publications

The Effects of Vitamin E-Coated Membrane Dialyzer Compared to Simvastatin in Patients on Chronic Hemodialysis

The Effects of Vitamin E-Coated Membrane Dialyzer Compared to Simvastatin in Patients on Chronic Hemodialysis

Progression of Atheroma

Cytokines and growth factors involved in apoptosis and proliferation of vascular smooth muscle cells

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