Oxidative stress–mediated nanotoxicity

Vardakas, Periklis; Kyriazis, Ioannis D.; Kourti, Maria; Tekos, Fotios; Kouretas, Demetrios

doi:10.1016/b978-0-323-99877-2.00012-6

Cited by 1 publication

(2 citation statements)

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“…Gold nanoparticles have been reported to have a cytotoxic effect through induction of oxidative stress [100,101]. However, in this study, green synthesized AuNPs showed high antioxidant activity.…”

Section: Antioxydant Activity Of Aunpsmentioning

confidence: 52%

“…The effectiveness of infection control depends on the treatment strategy chosen; this also affects the evaluation of MIC (minimum inhibitory concentration) values [90]. In the current study, MIC values were evaluated based for the lowest concentration of AuNPs Gold nanoparticles have been reported to have a cytotoxic effect through induction of oxidative stress [100,101]. However, in this study, green synthesized AuNPs showed high antioxidant activity.…”

Section: Antioxydant Activity Of Aunpsmentioning

confidence: 87%

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Green Synthesis of Gold Nanoparticles by Aqueous Extract of Zingiber officinale: Characterization and Insight into Antimicrobial, Antioxidant, and In Vitro Cytotoxic Activities

Fouda

Eid

Guibal³

et al. 2022

Applied Sciences

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The main challenge for researchers in the biomedical sectors concerns the development of new active compounds through cost-effectiveness, rapid, simple, and ecofriendly methods to overcome antibiotic resistance to pathogenic microbes. Herein, gold nanoparticles (AuNPs) were fabricated by a green approach through the reduction of chloroauric acid (HAuCl4) by harnessing the metabolites present in the aqueous extract of Zingiber officinale rhizome. UV-Vis spectroscopy, FT-IR, XRD, TEM, DLS, and zeta potential were used to characterize phytosynthesized AuNPs. In addition, the antimicrobial effect was investigated against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), unicellular fungi (Candida albicans), and multicellular fungi (Aspergillus brasiliensis). Antioxidant and in vitro cytotoxic activities were assessed. TEM and XRD showed the successful formation of spherical and crystalline structures, with sizes in the range of 5–53 nm (average size: 15.11 ± 8.5 nm). The zeta potential value (i.e., –28.8 mV) explains the high stability of synthesized AuNPs. AuNPs exhibit promising activity against prokaryotic and eukaryotic microorganisms with variable inhibition zones and low MIC values in the range of 25–6.25 µg mL−1. Phytosynthesized AuNPs exhibit DPPH scavenging activity with percentages of 87.6 ± 0.5% at a maximum concentration (1000 µg mL−1), which can be compared with ascorbic acid (97.3 ± 0.2%). Moreover, the AuNPs displayed a target-oriented effect for cancer cell lines HepG2 and MCF7 at low IC50 concentrations of 131.9 ± 9.34 and 288.23 ± 31.39 µg mL−1 compared to the normal oral epithelial OEC cell line (487.612 ± 3.53 µg mL−1). Overall, the phytosynthesized AuNPs show wide activities that enable their use in various biomedical and biotechnological applications.

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Section: Antioxydant Activity Of Aunpsmentioning

confidence: 52%