Oxidative stress mediated cytogenotoxicological effects of phytol in wistar albino rats

Alencar, Marcus Viní­cius Oliveira Barros de; Islam, Muhammad Torequl; Reis, Antonielly Campinho dos; Santos, José Victor de Oliveira; Nunes, Adriana Maria Viana; Silva, Felipe Cavalcante Carneiro da; Machado, Keylla da Conceição; Sousa, João Marcelo de Castro e; Reiner, Željko; Martorell, Miquel; Fagoonee, Sharmila; Sharifi‐Rad, Javad; Melo‐Cavalcante, Ana Amélia de Carvalho

doi:10.1007/s13596-022-00628-4

Cited by 3 publications

(2 citation statements)

References 70 publications

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“…A common and distinctive feature of type‐2 DM is chronic hyperglycemia and glucotoxicity, resulting from impaired insulin biosynthesis and secretion by β‐cells and in turn, gradually deteriorates β‐cell function (Wu et al, 2016). The mechanism of glucotoxicity is partially mediated through either excessive production of reactive oxygen species, or a reduction of endogenous antioxidant defense power of free‐radical quenching (antioxidant) enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, or both mechanisms leading to oxidative stress (de Alencar et al, 2023). β‐Cells are extensively susceptible to reactive oxygen species and further glucotoxicity leading to damage to cellular macromolecules, including DNA, proteins, and lipids because of their relatively low expression of antioxidant enzymes (Pal, 2013).…”

Section: Polysaccharides' Antidiabetic Action Mechanismsmentioning

confidence: 99%

“…mutase (SOD), catalase, and glutathione peroxidase, or both mechanisms leading to oxidative stress(de Alencar et al, 2023). β-Cells are extensively susceptible to reactive oxygen species and further glucotoxicity leading to damage to cellular macromolecules, including DNA, proteins, and lipids because of their relatively low expression of antioxidant enzymes(Pal, 2013).…”

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confidence: 99%

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Polysaccharides (pectin, mucilage, and fructan inulin) and their fermented products: A critical analysis of their biochemical, gut interactions, and biological functions as antidiabetic agents

El‐Nashar,

Taleb,

EL‐Shazly

et al. 2023

Phytotherapy Research

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Diabetes mellitus is a globally metabolic endocrine syndrome marked by a deficiency of insulin secretion (type‐1 DM) or glucose intolerance arising from insulin response impairment (type‐2 DM) leading to abnormal glucose metabolism. With an increasing interest in natural dietary components for diabetes management, the identification of novel agents witnessed major discoveries. Plant‐derived mucilage, pectin, and inulin are important non‐starch polysaccharides that exhibit effective antidiabetic properties often termed soluble dietary fiber (SDF). SDF affects sugar metabolism through multiple mechanisms affecting glucose absorption and diffusion, modulation of carbohydrate metabolizing enzymes (α‐amylase and α‐glucosidase), ameliorating β‐pancreatic cell dysfunction, and improving insulin release or sensitivity. Certain SDFs inhibit dipeptidyl peptidase‐4 and influence the expression levels of genes related to glucose metabolism. This review is designed to discuss holistically and critically the antidiabetic effects of major SDF and their underlying mechanisms of action. This review should aid drug discovery approaches in developing novel natural antidiabetic drugs from SDF.

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Section: Polysaccharides' Antidiabetic Action Mechanismsmentioning

confidence: 99%

mentioning

confidence: 99%

Polysaccharides (pectin, mucilage, and fructan inulin) and their fermented products: A critical analysis of their biochemical, gut interactions, and biological functions as antidiabetic agents

El‐Nashar,

Taleb,

EL‐Shazly

et al. 2023

Phytotherapy Research

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Antioxidant and antimicrobial potential of compounds isolated from Carissa opaca

Ahmad,

Khan,

Jamil

et al. 2024

Food Bioscience

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Antioxidant Potential of Ethiopian Medicinal Plants and Their Phytochemicals: A Review of Pharmacological Evaluation

Nigussie,

Siyadatpanah,

Norouzi

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. Free radicals are very reactive molecules produced during oxidation events that in turn initiate a chain reaction resulting in cellular damage. Many degenerative diseases in humans, including cancer and central nervous system damage, are caused by free radicals. Scientific evidence indicates that active compounds from natural products can protect cells from free radical damage. As a result, the aim of this review is to provide evidence of the use of diverse Ethiopian medicinal plants with antioxidant properties that have been scientifically validated in order to draw attention and foster further investigations in this area. Methods. The keywords antioxidant, radical scavenging activities, reactive oxygen species, natural product, Ethiopian Medicinal plants, and 2, 2-Diphenyl-1-picrylhydrazyl radical scavenging assay (DPPH) were used to identify relevant data in the major electronic scientific databases, including Google Scholar, ScienceDirect, PubMed, Medline, and Science domain. All articles with descriptions that were accessed until November 2022 were included in the search strategy. Results. A total of 54 plant species from 33 families were identified, along with 46 compounds isolated. More scientific studies have been conducted on plant species from the Brassicaceae (19%), Asphodelaceae (12%), and Asteraceae (12%) families. The most used solvent and extraction method for plant samples are methanol (68%) and maceration (88%). The most examined plant parts were the leaves (42%). Plant extracts (56%) as well as isolated compounds (61%) exhibited significant antioxidant potential. The most effective plant extracts from Ethiopian flora were Bersama abyssinica, Solanecio gigas, Echinops kebericho, Verbascum sinaiticum, Apium leptophyllum, and Crinum abyssinicum. The best oxidative phytochemicals were Rutin (7), Flavan-3-ol-7-O-glucoside (8), Myricitrin (13), Myricetin-3-O-arabinopyranoside (14), 7-O-Methylaloeresin A (15), 3-Hydroxyisoagatholactone (17), β-Sitosterol-3-O-β-D-glucoside (22), Microdontin A/B (24), and Caffeic acid (39). Conclusion. Many crude extracts and compounds exhibited significant antioxidant activity, making them excellent candidates for the development of novel drugs. However, there is a paucity of research into the mechanisms of action as well as clinical evidence supporting some of these isolated compounds. To fully authenticate and then commercialize, further investigation and systematic analysis of these antioxidant-rich species are required.

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Oxidative stress mediated cytogenotoxicological effects of phytol in wistar albino rats

Cited by 3 publications

References 70 publications

Polysaccharides (pectin, mucilage, and fructan inulin) and their fermented products: A critical analysis of their biochemical, gut interactions, and biological functions as antidiabetic agents

Polysaccharides (pectin, mucilage, and fructan inulin) and their fermented products: A critical analysis of their biochemical, gut interactions, and biological functions as antidiabetic agents

Antioxidant and antimicrobial potential of compounds isolated from Carissa opaca

Antioxidant Potential of Ethiopian Medicinal Plants and Their Phytochemicals: A Review of Pharmacological Evaluation

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