Oxidative stress markers in the saliva of patients with oral lichen planus

Gonzaga, Amanda Katarinny Goes; Vasconcelos, Roseane Carvalho; Lopes, Maria Luiza Diniz de Sousa; Medeiros, Maurília Raquel de Souto; Araújo, Aurigena Antunes de; Silveira, Éricka Janine Dantas da; Medeiros, Ana Miryam Costa de

doi:10.1016/j.prp.2023.154569

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Patients with OLP have been shown to exhibit significantly increased oxidative stress markers and decreased antioxidant markers in saliva and serum/plasma. 48 In patients with RAU, the levels of TNF-α, IL-2 and total oxidation state is shown to be increased, while the level of IL-10 is decreased. 49 Abnormal cytokine activity may accelerate lipid peroxidation and lead to the increase of serum oxidative stress, which plays an important role in oxidative/antioxidant defence in patients with RAU.…”

Section: Neurobiological Mechanismsmentioning

confidence: 94%

Oral mucosal diseases and psychosocial factors: progress in related neurobiological mechanisms

Zhou,

Lin

2023

J Int Med Res

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The aetiology of oral mucosal diseases, such as recurrent aphthous ulcer (RAU), oral lichen planus (OLP) and burning mouth syndrome (BMS), involves many factors, and it remains difficult for clinicians to effectively relieve disease symptoms and formulate coping strategies. With the rapid development of psychology, the role of mental and psychological factors in RAU, OLP and BMS has gradually attracted researchers attention, but the specific mechanism has not been completely determined. This narrative review describes the potential neurobiological mechanism of oral mucosal diseases and detailed psychological factors after introducing relevant research into psychological factors and oral mucosal diseases. Future research strategies and innovations needed to understand and treat oral mucosal diseases and psychological factors, as well as how to prevent oral mucosal diseases by regulation of the neuroendocrine system, are also discussed.

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Section: Neurobiological Mechanismsmentioning

confidence: 94%

Oral mucosal diseases and psychosocial factors: progress in related neurobiological mechanisms

Zhou,

Lin

2023

J Int Med Res

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“…Goes Gonzaga et al found that level of GSH in OLP patients was not remarkably different in comparison with healthy people. However, despite of conducted researches on the effectiveness of oxidative stress markers of saliva in OLP patients, he proposed a better standardization of methods for more accurate conclusion [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the salivary level of glutathione reductase, catalase and free thiol in patients with oral lichen planus

et al. 2023

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Objective Oral lichen planus (OLP) is a usual chronic inflammatory disease of the oral mucosa with malignant capacity, whose pathogenesis is not yet well known. Free radicals and reactive oxygen species may have a vital role in the pathogenesis of oral lichen planus. This study aimed to assess Glutathione reductase, catalase, and free thiol levels in the saliva of OLP patients and compare it with healthy people. Methods In this cross-sectional study, 35 patients with OLP and 20 healthy people were involved. Five mL of whole, unstimulated saliva samples were collected in the morning, and the salivary levels of antioxidants were measured by ELISA technique. In this experiment, sex, age and OLP types were also evaluated. Results There was a significant decrease in the patients’ salivary level of Glutathione reductase (0.2043 mU/ml in patients and 0.3901 mU/ml in the control group) and catalase (0.1525 mU/ml in patients and 0.2700 mU/ml in the control group) (p = 0.001). But there were no differences between the two groups regarding free-thiol levels (0.0586 mU/ml in patients and 0.0569 mU/ml in the control group) (p = 0.7). However, there was no correlation between age and gender with the antioxidants’ contents. There was a significant decrease in glutathione reductase and catalase in the erosive type than in the non-erosive type. Conclusions In this study, we found that the salivary levels of Glutathione reductase and Catalase were lower in OLP patients than in the healthy group, which means these antioxidants were affected by OLP and also associated with the type of it. So salivary Glutathione reductase and Catalase levels may be used as biomarkers for OLP monitoring and treatment.

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“…Considering that the skin is the body’s interface with the external environment, and in the environment, there are numerous aggressors that can create an imbalance between oxidants and antioxidants, it is considered that oxidative stress plays an important role in chronic inflammatory skin diseases. Regarding LP, there are numerous studies that investigate the level of oxidative stress in patients with oral LP [ 11 , 12 , 13 ], the studies being less numerous in the case of cutaneous LP. Recently, we performed a review that focused on oxidative stress markers in cutaneous LP (CLP) to provide a more complete understanding of the involvement of oxidative stress in this disease and identified that there is an increased level of prooxidants in conjunction with a decrease in the activity of enzymatic and non-enzymatic antioxidants.…”

Section: Introductionmentioning

confidence: 99%

The Interplay between Nitrosative Stress, Inflammation, and Antioxidant Defense in Patients with Lichen Planus

Tampa,

Nicolae,

Ene

et al. 2024

Antioxidants

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Background: Lichen planus (LP) is a chronic inflammatory skin disease of unelucidated etiology. LP immunopathogenesis is mainly governed by cytotoxic T lymphocytes that mediate an immune response in basal keratinocytes, which may transform into a reservoir of antigens able to initiate an autoimmune reaction. However, other pathogenic pathways complement these mechanisms. Recent studies highlight the involvement of nitrosative stress in the pathogenesis of chronic inflammatory skin diseases. Current data on its role in the pathogenesis of LP are scarce. Methods: In this article, we investigated nitrosative stress in 40 cutaneous LP (CLP) patients compared to 40 healthy subjects using serum markers including nitrosative stress markers—direct nitrite, total nitrite, nitrate and symmetric dimethylarginine (SDMA), total antioxidant status (TAS), and hsCRP, a marker of inflammation, and analyzed the relationship between nitrosative stress, antioxidant defense, and inflammation to offer new insights into the role of the NO pathway in LP pathogenesis. Results: We identified significantly higher serum levels of direct nitrite, total nitrite, nitrate, SDMA and hsCRP, and significantly lower levels of TAS in CLP patients versus controls. There were significant negative correlations between the serum levels of TAS and significantl positive correlations between the serum levels of hsCRP and the analyzed nitrosative stress markers in patients with CLP. Conclusion: Our results indicate an increased level of nitrosative stress in LP patients that correlates with a pro-inflammatory status and altered antioxidant defense.

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Oxidative stress markers in the saliva of patients with oral lichen planus

Cited by 4 publications

References 24 publications

Oral mucosal diseases and psychosocial factors: progress in related neurobiological mechanisms

Oral mucosal diseases and psychosocial factors: progress in related neurobiological mechanisms

Evaluation of the salivary level of glutathione reductase, catalase and free thiol in patients with oral lichen planus

The Interplay between Nitrosative Stress, Inflammation, and Antioxidant Defense in Patients with Lichen Planus

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