Oxidative Stress Markers and Severity of Obstructive Sleep Apnea

Cofta, Szczepan; Winiarska, Hanna; Płóciniczak, Alicja; Bielawska, Lena; Brożek, Alicja; Piorunek, Tomasz; Kostrzewska, T M; Wysocka, Ewa

doi:10.1007/5584_2019_433

Cited by 18 publications

(9 citation statements)

References 19 publications

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“…Therefore, metabolic abnormalities found in morbid obesity may be linked not only to adiposity per se but also to concomitant OSA. Several mechanisms, including direct effects of hypoxia [31], oxidative stress [32,33] sympathetic nervous system activation [34] and the associated increase in catecholamines [34][35][36][37], and alterations in pro-inflammatory cytokines such as interleukin-6, tumor necrosis factor-a [38] and hypoxia-inducible factor-1a [39] seem to play a critical role in the metabolism of carbohydrates. In a recent study investigating the effects of 24 weeks of weight-loss intervention plus CPAP therapy in obese individuals with OSA, we have shown that correction of intermittent hypoxemia improves systemic and obesity-associated inflammatory markers [12].…”

Section: Discussionmentioning

confidence: 99%

Postprandial glucose and HbA1c are associated with severity of obstructive sleep apnoea in non-diabetic obese subjects

Cignarelli

Ciavarella

Barbaro

et al. 2021

J Endocrinol Invest

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Introduction Obstructive sleep apnoea (OSA) is an underdiagnosed condition frequently associated with glycaemic control impairment in patients with type 2 diabetes. Aim To assess the relationship between glycometabolic parameters and OSA in obese non-diabetic subjects. Methods Ninety consecutive subjects (mean age 44.9 ± 12 years, mean BMI 42.1 ± 9 kg/m2) underwent polysomnography and a 2-h oral glucose tolerance test (OGTT). Results OSA was identified in 75% of subjects, with a higher prevalence of males compared to the group of subjects without OSA (62% vs 32%, p = 0.02). Patients with OSA had comparable BMI (42.8 kg/m2 vs 39.4 kg/m2), a higher average HbA1c (5.8% vs 5.4%, p < 0.001), plasma glucose at 120 min during OGTT (2 h-PG; 123 mg/dl vs 97 mg/dl, p = 0.009) and diastolic blood pressure (81.1 mmHg vs 76.2 mmHg, p = 0.046) than obese subjects without OSA. HbA1c and 2 h-PG were found to be correlated with the apnoea-hypopnoea index (AHI; r = 0.35 and r = 0.42, respectively) and with percent of sleep time with oxyhaemoglobin saturation < 90% (ST90; r = 0.44 and r = 0.39, respectively). Further, in a linear regression model, ST90 and AHI were found to be the main determinants of 2 h-PG (β = 0.81, p < 0.01 and β = 0.75, p = 0.02, respectively) after controlling for age, sex, waist circumference, physical activity, and C-reactive protein. Similarly, ST90 and AHI persisted as independent determinants of HbA1c (β = 0.01, p = 0.01 and β = 0.01, p = 0.01, respectively). Conclusion Beyond the traditional clinical parameters, the presence of a normal-high value of 2 h-PG and HbA1c should raise suspicion of the presence of OSA in obese subjects.

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Section: Discussionmentioning

confidence: 99%

Postprandial glucose and HbA1c are associated with severity of obstructive sleep apnoea in non-diabetic obese subjects

Cignarelli

Ciavarella

Barbaro

et al. 2021

J Endocrinol Invest

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“…This makes it difficult to evaluate the oxidant-antioxidant status because these disorders accompanying OSAS have the potential to reduce antioxidant capacity and increase oxidant load [6]. Cofta et al [14] stated that the increase in OSAS severity correlated with the increase in total antioxidant status and thiobarbituric acidreacting substances plasma levels, and these markers may play important roles in the classification of the metabolic properties of OSAS. In our study, there was no significant difference between pOSAS and npOSAS groups in terms of TAS and MDA levels.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the relationship between polysomnography parameters, physical examination findings and oxidative stress parameters in patients with obstructive sleep apnea syndrome

Yücel¹,

Arbağ²,

Yöndemli³

et al. 2021

Journal of Surgery and Medicine

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“…The results showed a higher total antioxidant status and thiobarbituric acid-reacting substances in the more severe cases. [ 67 ] It is also very likely that certain predisposition risk factors associated with obesity (i.e., hypertension, diabetes mellitus, etc.) contribute to these changes.…”

Section: Methodsmentioning

confidence: 99%

An organ systems-based review of outcomes associated with sleep apnea in hospitalized patients

Sheikh

Kuperberg

2021

Medicine

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The current global health crisis due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has prompted the medical community to investigate the effects of underlying medical conditions, including sleep-disordered breathing, on inpatient care. Obstructive sleep apnea (OSA) is a common form of sleep-disordered breathing that may complicate numerous acquired conditions, particularly in inpatient and critical care settings. Viral pneumonia is a major contributor to intensive care unit (ICU) admissions and often presents more severely in patients with underlying pulmonary disease, especially those with obesity and OSA. This review summarizes the most recent data regarding complications of both OSA and obesity and highlights their impact on clinical outcomes in hospitalized patients. Additionally, it will highlight pertinent evidence for the complications of OSA in an organ-systems approach. Finally, this review will also discuss impatient treatment approaches for OSA, particularly in relation to the SARS-CoV-2 pandemic.

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Oxidative Stress Markers and Severity of Obstructive Sleep Apnea

Cited by 18 publications

References 19 publications

Postprandial glucose and HbA1c are associated with severity of obstructive sleep apnoea in non-diabetic obese subjects

Postprandial glucose and HbA1c are associated with severity of obstructive sleep apnoea in non-diabetic obese subjects

Evaluation of the relationship between polysomnography parameters, physical examination findings and oxidative stress parameters in patients with obstructive sleep apnea syndrome

An organ systems-based review of outcomes associated with sleep apnea in hospitalized patients

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