Oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome in a Nigerian tertiary hospital

Enechukwu, Chukwunonso Isaiah; Onuegbu, Anaelechi J.; Olisekodiaka, Japhet M.; Eleje, George Uchenna; Ikechebelu, Joseph Ifeanyichukwu; Ugboaja, JO; Amah, Ubuo K.; Okwara, John E.; Igwegbe, AO

doi:10.5468/ogs.2019.62.5.335

Cited by 38 publications

(33 citation statements)

References 29 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidative stress is considered as the imbalance between oxidants and antioxidants and the increased production of reactive oxygen species (ROS) [4]. In the present study, some serum oxidative markers were detected and the results showed that serum concentrations of SOD were significantly lower in PCOS groups, MDA, NO and NOS were significantly higher in PCOS group compared with the control group, which was consistent with previous study on PCOS patients [21]. These findings dedicated that there is an oxidative stress in these DHEA-induced PCOS rats.…”

Section: Discussionsupporting

confidence: 91%

The Effect of Glutamine on Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Rats

Ding

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Previous studies have shown that chronic inflammation and oxidative stress may play an important role in the pathophysiology of polycystic ovary syndrome (PCOS), and glutamine (Gln) showed the anti-inflammatory and antioxidant properties. So the aim of this study is to investigate the effect of glutamine supplementation on PCOS rats. Methods Female Sprague–Dawley rats were randomly assigned into five groups (n = 10 /group), control group, PCOS group, PCOS+0.5g/kg Gln group, PCOS+0.75g/kg Gln group and PCOS+1.0g/kg Gln group. All the PCOS rats were administrated with 6 mg/100 g dehydroepiandrosterone (DHEA) for 20 consecutive days, all the PCOS+Gln groups were intraperitoneal injected Gln twice in the next morning after the last DHEA injection. All the samples were collected 12 hours after the last administration. Ovarian histological examinations were analyzed and the concentration of serum hormone, inflammatory and oxidative stress factors were measured. Results There was no obvious ovarian histological change among the PCOS group and PCOS+Gln groups. All the detected inflammation factors (IL-6, IL-18, TNF-α and CRP) showed significantly higher in all the PCOS groups compared to the control group (P<0.01), and were significantly decreased with the low supplementation of glutamine (P<0.01, include 0.5g/kg group and 0.75g/kg group).Concentrations of SOD were significantly lower in all the PCOS groups (P<0.01) compared to the control group, and increased significantly with the low supplementation of glutamine (P<0.01, include 0.5g/kg group and 0.75g/kg group). Serum concentrations of MDA, NO and NOS were significantly higher in PCOS group (P<0.01) compared with the control group, and significantly decreased to the comparative levels of control group with the low supplementation of glutamine (P<0.01, include 0.5g/kg group and 0.75g/kg group). Conclusion There is low-grade inflammation and oxidative stress in DHEA-induced PCOS rats. The supplementation of glutamine with doses of 0.5g/kg and 0.75g/kg could effectively ameliorate the inflammatory and oxidative stress conditions of PCOS.

show abstract

Section: Discussionsupporting

confidence: 91%

The Effect of Glutamine on Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Rats

Ding

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Dyslipidemia could be viewed as a possible complication of PCOS, with abnormalities in lipid and lipoprotein metabolism 23 .PCOS women had higher TG compared to controls, yet with no signi cant changes in the levels of TC, HDL-C, and LDL-C. Contradictorily, with regard to altered TG levels, no signi cant difference in levels of TG was observed between the two groups a Nigerian study 24 .Nevertheless, diminished SOD levels observed in the current report is in homology to the ndings reported in Nigerian study. This variation could be attributed to the geographical location and origin.…”

Section: Discussionmentioning

confidence: 96%

Antioxidant Status in Relation to Heavy Metals Induced Oxidative Stress in Patients With Polycystic Ovarian Syndrome (PCOS)

Abudawood

Tabassum

Alanazi

et al. 2021

Preprint

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is a global health concern in women of reproductive age as 1/15th women worldwide, is affected by this syndrome. PCOS is marked by hyperandrogenism, anovulation, menstrual abnormalities, and polycystic ovaries. Metals like arsenic, cadmium, lead and mercury are considered as systemic toxicants/human carcinogens and seems to have devastating effect on the human, even at minimal exposure. One of the probable etiological factor for PCOS identified is oxidative stress. In view of the probable association between oxidative stress, metal toxicity and PCOS, the present study evaluated the role of heavy metal in generation of oxidative stress among females. This prospective study included 106 women (56 women diagnosed with PCOS and 50women who were not diagnosed with PCOS as control women). There was no significant changes in the sociodemographic characteristics between the two groups except with the irregularity in menses and presence of acne. Levels of serum As, Cd, Pb, Hg increased and serum GSH and SOD levels diminished significantly in PCOS group compared to control at P<0.001. SOD was negatively correlated with As& Pb at P<0.05. Additionally, PCOS group exhibited a strong negative correlation between GSH and As (P<0.01), GSH and Pb (p<0.05) and GSH and Hg (P<0.01). Furthermore, As correlated positively with increased levels of Cd, Pb and Hg among PCOS women. A significant positive correlation was determined between Pb & Cd and Cd & Hg at P<0.001. The outcome of the study provides clear insight of the role of metal induced oxidative stress that plays avitalrole in the pathophysiology underlying PCOS and suggestive of the use of these markers as prognostic tools to circumvent the consequences of high risk exposure to these metals among females.

show abstract

“…A case-control study conducted by Enechukwu et al on 50 PCOS patients revealed a significant decrease in the total antioxidant capacity (TAC) (p<o.oo1) and activity of SOD (p<0.001) when compared with 50 females with normal ovarian function [16]. Moreover, there was a significant elevation in the level of malondialdehyde (MDA) [16]. MDA, a known marker of oxidative stress, is the final product of polyunsaturated fatty acid peroxidation [17].…”

Section: Review Oxidative Stress and Pcosmentioning

confidence: 99%

Oxidative Stress in Polycystic Ovarian Syndrome and the Effect of Antioxidant N-Acetylcysteine on Ovulation and Pregnancy Rate

Sandhu

Waqar

Jain

et al. 2021

Cureus

View full text Add to dashboard Cite

Polycystic ovarian syndrome (PCOS) is an endocrinological condition that leads to infertility in many females. N-acetylcysteine (NAC), a novel antioxidant, is being used as an adjuvant to treat infertility in females suffering from PCOS. This review aims to evaluate oxidative stress in females suffering from PCOS and assess whether the anti-oxidizing properties of NAC are beneficial in enhancing the rate of ovulation and pregnancy in infertile PCOS females. A literature search was conducted manually on PubMed and Google Scholar databases using the following keywords: "N-Acetylcysteine," "PCOS," "Oxidative stress," "Antioxidants," and "infertility" alone and/or in combination for data collection. The studies were manually screened and, after applying inclusion-exclusion criteria, 32 studies consisting of 2466 females of the reproductive age group are included in this review. Our review revealed that females suffering from PCOS tend to show elevated levels of inflammatory markers and a decrease in antioxidant capacity. When used in combination with clomiphene citrate or letrozole, NAC increases ovulation and pregnancy rate in infertile females suffering from PCOS and positively affects the quality of oocytes and number of follicles ≥18mm. Moreover, its side effect profile is low. It also results in a mild increase in endometrial thickness in some females. Future studies on a large sample size using NAC alone are highly recommended to evaluate its role as a single-drug therapy for treating infertility in females suffering from PCOS.

show abstract

Oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome in a Nigerian tertiary hospital

Cited by 38 publications

References 29 publications

The Effect of Glutamine on Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Rats

The Effect of Glutamine on Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Rats

Antioxidant Status in Relation to Heavy Metals Induced Oxidative Stress in Patients With Polycystic Ovarian Syndrome (PCOS)

Oxidative Stress in Polycystic Ovarian Syndrome and the Effect of Antioxidant N-Acetylcysteine on Ovulation and Pregnancy Rate

Contact Info

Product

Resources

About