Oxidative Stress Levels in Myelodysplastic Syndrome Patients: Their Relationship to Serum Ferritin and Haemoglobin Values

Saigo, Katsuyasu; Takenokuchi, Mariko; Hiramatsu, Yasushi; Tada, Hayato; Hishita, Terutoshi; Takata, Masanobu; Misawa, Mitsuko; Imoto, Shuhei; Imashuku, Shinsaku

doi:10.1177/147323001103900539

Cited by 46 publications

(35 citation statements)

References 20 publications

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“…These findings are consistent with previous studies suggesting a relationship between IOL and the increased production of ROS in MDS 4. Although current understanding of these effects in MDS is still waiting for more evidence, it is consensual that IOL should be monitored and managed in selected patients based on risk stratification, life expectancy, transfusion history, iron burden and ongoing transfusion requirement.…”

Section: Discussionsupporting

confidence: 91%

Increased parameters of oxidative stress and its relation to transfusion iron overload in patients with myelodysplastic syndromes

et al. 2013

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Section: Discussionsupporting

confidence: 91%

Increased parameters of oxidative stress and its relation to transfusion iron overload in patients with myelodysplastic syndromes

et al. 2013

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“…MDS patients show increased levels of oxidative stress, which is further aggravated by iron overload [14][15][16][17][18][19][20][21]. The resulting oxidative DNA damage, worsened by iron overload [22], may contribute to mutagenesis in the bone marrow.…”

Section: Iron Overload and Bone Marrow Functionmentioning

confidence: 99%

Iron overload in myelodysplastic syndromes (MDS)

Gattermann

2017

Int J Hematol

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Iron overload (IOL) starts to develop in MDS patients before they become transfusion-dependent because ineffective erythropoiesis suppresses hepcidin production in the liver and thus leads to unrestrained intestinal iron uptake. However, the most important cause of iron overload in MDS is chronic transfusion therapy. While transfusion dependency by itself is a negative prognostic factor reflecting poor bone marrow function, the ensuing transfusional iron overload has an additional dose-dependent negative impact on the survival of patients with lower risk MDS. Cardiac dysfunction appears to be important in this context, as a consequence of chronic anemia, age-related cardiac comorbidity, and iron overload. Another potential problem is iron-related endothelial dysfunction. There is some evidence that with increasing age, high circulating iron levels worsen the atherosclerotic phenotype. Transfusional IOL also appears to aggravate bone marrow failure in MDS, through unfavorable effects on mesenchymal stromal cells as well a hematopoietic cells, particularly erythroid precursors. Patient series and clinical trials have shown that the iron chelators deferoxamine and deferasirox can improve hematopoiesis in a minority of transfusion-dependent patients. Analyses of registry data suggest that iron chelation provides a survival benefit for patients with MDS, but data from a prospective randomized clinical trial are still lacking.

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“…Several studies have found elevated levels of oxidative stress markers (reactive oxygen species) and reduced levels of antioxidants (reduced glutathione (GSH)) in MDS patients and their correlation with serum ferritin levels [3, 4]. However, increased oxidative stress was revealed, even in the patients not receiving transfusions [5].…”

Section: Introductionmentioning

confidence: 99%

Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload

Pimková

Chrastinová

Suttnar

et al. 2014

Oxidative Medicine and Cellular Longevity

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The role of oxidative stress in the initiation and progression of myelodysplastic syndromes (MDS) as a consequence of iron overload remains unclear. In this study we have simultaneously quantified plasma low-molecular-weight aminothiols, malondialdehyde, nitrite, and nitrate and have studied their correlation with serum iron/ferritin levels, patient treatment (chelation therapy), and clinical outcomes. We found significantly elevated plasma levels of total, oxidized, and reduced forms of cysteine (P < 0.001) , homocysteine (P < 0.001), and cysteinylglycine (P < 0.006) and significantly depressed levels of total and oxidized forms of glutathione (P < 0.03) and nitrite (P < 0.001) in MDS patients compared to healthy donors. Moreover, total (P < 0.032) and oxidized cysteinylglycine (P = 0.029) and nitrite (P = 0.021) differed significantly between the analyzed MDS subgroups with different clinical classifications. Malondialdehyde levels in plasma correlated moderately with both serum ferritin levels (r = 0.78, P = 0.001) and serum free iron levels (r = 0.60, P = 0.001) and were significantly higher in patients with iron overload. The other analyzed compounds lacked correlation with iron overload (represented by serum iron/ferritin levels). For the first time our results have revealed significant differences in the concentrations of plasma aminothiols in MDS patients, when compared to healthy donors. We found no correlation of these parameters with iron overload and suggest the role of oxidative stress in the development of MDS disease.

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Oxidative Stress Levels in Myelodysplastic Syndrome Patients: Their Relationship to Serum Ferritin and Haemoglobin Values

Cited by 46 publications

References 20 publications

Increased parameters of oxidative stress and its relation to transfusion iron overload in patients with myelodysplastic syndromes

Increased parameters of oxidative stress and its relation to transfusion iron overload in patients with myelodysplastic syndromes

Iron overload in myelodysplastic syndromes (MDS)

Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload

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