Oxidative stress is associated with characteristic features of the dysfunctional chronic pain phenotype

Abstract

The dysfunctional chronic pain (Dysfunctional CP) phenotype is an empirically identifiable CP subtype with unclear pathophysiological mechanisms that cuts across specific medical CP diagnoses. This study tested whether the multidimensional pain and psychosocial features that characterize the dysfunctional CP phenotype are associated broadly with elevated oxidative stress (OS). Measures of pain intensity, bodily extent of pain, catastrophizing cognitions, depression, anxiety, sleep disturbance, pain interference, and function were completed by 84 patients with chronic osteoarthritis before undergoing total knee arthroplasty. Blood samples were obtained at the initiation of surgery before incision or tourniquet placement. Plasma levels of F2-isoprostanes and isofurans, the most highly specific measures of in vivo OS, were quantified using gas chromatography/negative ion chemical ionization mass spectrometry. The results indicated that controlling for differences in age, sex, and body mass index, higher overall OS (mean of isoprostanes and isofurans) was associated with significantly (P , 0.05) greater pain intensity, more widespread pain, greater depressive symptoms and pain catastrophizing, higher pain interference, and lower function. OS measures were not significantly associated with sleep disturbance or anxiety levels (P .0.10). The results build on prior case-control findings suggesting that presence of a CP diagnosis is associated with elevated OS, highlighting that it may specifically be individuals displaying characteristics of the dysfunctional CP phenotype who are characterized by elevated OS. Clinical implications of these findings remain to be determined.

Preventive treatment modifies endothelial function and oxidative stress status in patients with migraine: an observational study

“…Increasing evidence suggest isoprostanes are involved in the complex interplay underlying cardiovascular homeostasis between low-grade in ammation, lipid peroxidation, and platelet activation [48]. To date there are few clinical studies aimed at evaluating isoprostanes or other arachidonic acid derivatives in chronic pain [49] and speci cally in migraine [50]. Helmersson and colleagues found no differences in isoprostane urine rates between ictal and interictal periods in 21 patients with migraine [51].…”

Perioperative oxidative stress predicts subsequent pain-related outcomes in the 6 months after total knee arthroplasty

“…Results regarding associations between preoperative OS and preoperative pain and psychosocial status in this project have been reported separately. 9…”

“…3,6,8,16,24,38 Consistent with associations between OS and pain, our recent findings in patients with osteoarthritis preparing to undergo TKA indicated that elevated preoperative OS was associated with higher preoperative pain intensity, functional limitations, depression, and catastrophizing, as well as more widespread chronic pain. 9…”

“…3,6,8,16,24,38 Consistent with associations between OS and pain, our recent findings in patients with osteoarthritis preparing to undergo TKA indicated that elevated preoperative OS was associated with higher preoperative pain intensity, functional limitations, depression, and catastrophizing, as well as more widespread chronic pain. 9 To assess OS in this study, we used the most sensitive and specific indexes of OS in vivo, circulating levels of F 2 -isoprostanes (IsoPs) and isofurans (IsoFs). 29,42,43 IsoPs and IsoFs are products of nonenzymatic oxidation of arachidonic acid.…”

GSK-3β inhibition alleviates arthritis pain via reducing spinal mitochondrial reactive oxygen species level and inflammation

“…Elevated oxidative stress is associated with OA pain. A measurement of 84 patients with chronic osteoarthritis show that higher oxidative stress is associated with greater pain intensity, more widespread pain, greater pain catastrophizing, higher pain interference, and lower function [13]. Mitochondria are the predominant source of intracellular reactive oxygen species (ROS) which is generated by the reaction between oxygen and a little quantity of electrons form electron transport chain (ETC) [14,15].…”