Oxidative Stress, Inflammation, and Vascular Aging in Hypertension

Guzik, Tomasz J.; Touyz, Rhian M.

doi:10.1161/hypertensionaha.117.07802

Cited by 500 publications

(337 citation statements)

References 102 publications

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“…Many of the features described in the EC-KO mice including vascular dysfunction, arterial remodeling, aortic stiffness, and aging are typically associated with oxidative stress and increased activation of Noxs as demonstrated in various models of CVD [42]. Our findings here of increased NADPH-mediated O 2 − production support this notion and suggest that EC Nox activity may be increased in EC-KO mice.…”

Section: Discussionsupporting

confidence: 78%

Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

et al. 2020

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Figure 6. Vasodilation in coronary arteries measured ex vivo in small wire organ bath set-ups Relaxations to ACh (A), SNP-induced vasodilatation (B), ADPβS (C) and UTPγS (D) in coronary rings preconstricted with U46619. Relaxations to ADPβS (E) and UTPγS (F) in coronary rings preconstricted with KCl 30 mM. *** P<0.0001 (GLM-RM, EC-KO-3 months vs WT-3 months and EC-KO-5 months vs WT-5 months). At 3 months, coronary arteries from seven EC-KO and eight to ninr WT were studied. At 5 months, arteries from seven EC-KO and ten WT were studied. 738

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Section: Discussionsupporting

confidence: 78%

Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

et al. 2020

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“…The first principal component was mainly contributed to by parameters that are typically aberrant in clinical cases of placenta‐mediated hypertension, including peripheral resistance, endoglin, cardiac output, and PlGF 12, 13. Conversely, the main contributors to the second and third principal components align with pathways to hypertension relating to maternal clinical characteristics and systemic inflammation, respectively 14, 15. These findings highlight the critical need for the development of pathway‐specific antihypertensive treatment strategies, with the understanding that hypertension in pregnancy does not involve only one common origin 7…”

Section: Discussionmentioning

confidence: 99%

Phenotypes of Pregnant Women Who Subsequently Develop Hypertension in Pregnancy

McLaughlin

Zhang

Lye

et al. 2018

JAHA

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BackgroundHypertensive disorders complicating pregnancy are a major cause of maternal death. Our objective was to evaluate maternal clinical, hemodynamic, and placental prognostic indicators in a consolidated manner to identify women who develop hypertension in pregnancy.Methods and ResultsTwenty‐six normotensive pregnant women from a specialized Placenta Clinic at increased risk of developing de novo hypertension and 20 normotensive healthy pregnant controls were recruited at 22 to 26 weeks' gestation. Fourteen maternal clinical, hemodynamic, and placental characteristics were assessed in the second trimester and aggregated. Principal component analysis of this combined data set determined that 3 dimensions accounted for 56% of the cohort variability. The first dimension accounted for 31% of the cohort variability, with significant contributions from total peripheral resistance, endoglin, and cardiac output. The second dimension was predominantly influenced by body mass index and mean arterial pressure, while uric acid and myeloperoxidase mainly contributed to the third dimension. Unsupervised clustering identified 3 groups within this combined data set. Total peripheral resistance was the most significant distinguishing parameter between these groups (P<0.0001), followed by placental growth factor, endoglin, and cardiac output (P<0.0001). Using these 4 parameters, a receiver operating curve was constructed with an area under the curve of 0.975 (95% confidence interval 0.93–1) for the prediction of developing hypertension in pregnancy.ConclusionsConsolidated assessment of prognostic indicators in the second trimester of pregnancy may be useful to characterize and distinguish pathways by which women may develop hypertension in pregnancy. This approach could contribute to the development of pathway‐specific preventative and antihypertensive treatment strategies.

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“…Hypertension is a complex group of clinical syndromes. Although the specific mechanisms remain unclear, it has been demonstrated that a variety of pathological factors are involved in the process of hypertension, among which immune responses and inflammation are most closely related to hypertension (Kirabo et al, 2014;Pober, 2014;Guzik and Touyz, 2017).…”

Section: Interleukin-12 Family Members and Hypertensionmentioning

confidence: 99%

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

Wang

et al. 2020

Front. Pharmacol.

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Cardiovascular diseases represent a complex group of clinical syndromes caused by a variety of interacting pathological factors. They include the most extensive disease population and rank first in all-cause mortality worldwide. Accumulating evidence demonstrates that cytokines play critical roles in the presence and development of cardiovascular diseases. Interleukin-12 family members, including IL-12, IL-23, IL-27 and IL-35, are a class of cytokines that regulate a variety of biological effects; they are closely related to the progression of various cardiovascular diseases, including atherosclerosis, hypertension, aortic dissection, cardiac hypertrophy, myocardial infarction, and acute cardiac injury. This paper mainly discusses the role of IL-12 family members in cardiovascular diseases, and the molecular and cellular mechanisms potentially involved in their action in order to identify possible intervention targets for the prevention and clinical treatment of cardiovascular diseases.

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Oxidative Stress, Inflammation, and Vascular Aging in Hypertension

Cited by 500 publications

References 102 publications

Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

Phenotypes of Pregnant Women Who Subsequently Develop Hypertension in Pregnancy

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

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