Oxidative Stress Induced Mechanisms in the Progression of Periodontal Diseases and Cancer: A Common Approach to Redox Homeostasis?

Soory, Menaka

doi:10.3390/cancers2020670

Cited by 29 publications

(24 citation statements)

References 118 publications

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“…Bacterial metabolites produced in the mouth including nitrosamines and acetaldehyde could have a systemic impact on carcinogenesis (45). It could also be that there are common risk factors including smoking, physical activity or diet as well as etiologic factors such as inflammation, oxidative stress or shared genetic factors that contribute to host susceptibility to both breast cancer and periodontal disease (27,46–48). The cytokine receptor activator of Nuclear Factor-κB (RANK) and its ligand (RANKL) may be important in breast carcinogenesis and metastasis (49–52).…”

Section: Discussionmentioning

confidence: 99%

Periodontal Disease and Breast Cancer: Prospective Cohort Study of Postmenopausal Women

Freudenheim

Genco

LaMonte

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Periodontal disease (PD) has been consistently associated with chronic disease; there are no large studies of breast cancer although oral-associated microbes are present in breast tumors. Methods In the Women’s Health Initiative Observational Study, a prospective cohort of postmenopausal women, 73,737 women without previous breast cancer were followed. Incident, primary, invasive breast tumors were verified by physician adjudication. PD was by self-report. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox proportional hazards, adjusted for breast cancer risk factors. Because the oral microbiome of those with PD differs with smoking status, we examined associations stratified by smoking. Results 2,124 incident, invasive breast cancer cases were identified after mean follow-up of 6.7 years. PD, reported by 26.1% of women, was associated with increased breast cancer risk (HR 1.14, 95% CI 1.03 to 1.26), particularly among former smokers who quit within 20 years (HR 1.36; 95% CI 1.05 to 1.77). Among current smokers, the trend was similar (HR 1.32; 95% CI 0.83 to 2.11); there were few cases (n=74) and the CI included the null. The population attributable fraction was 12.06% (95% CI 1.12 to 21.79) and 10.90% (95% CI 10.31 to 28.94) for PD among former smokers quitting within 20 years and current smokers, respectively. Conclusion PD, a common chronic inflammatory disorder, was associated with increased risk of postmenopausal breast cancer, particularly among former smokers who quit in the past 20 years. Impact Understanding a possible role of the oral microbiome in breast carcinogenesis could impact prevention.

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Section: Discussionmentioning

confidence: 99%

Periodontal Disease and Breast Cancer: Prospective Cohort Study of Postmenopausal Women

Freudenheim

Genco

LaMonte

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…It is known that smoking enforces oxidative stress triggering a series of events to follow, resulting in tumor. [33][34][35] MIEN1 has a redox motif and has previously been classified as a selenoprotein in the Rdx thioredoxin family with glutathione peroxidase 1 as its target. 36 The role of glutathione peroxidases is linked to reducing free radicals and thus the oxidative stress in the cells, leading to an inverse correlation between oxidative stress and the glutathione peroxidases.…”

Section: Discussionmentioning

confidence: 99%

MIEN1 promotes oral cancer progression and implicates poor overall survival

Rajendiran

Kpetemey

Maji

et al. 2015

Cancer Biology & Therapy

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Abbreviations: CRS, current reformed smoker; CS, current smoker; GFP, green fluorescent protein; HNSCC, head and neck squamous cell carcinoma; MIEN1, migration and invasion enhancer 1; MMP-9, matrix metallopeptidase 9; NF-kB, nuclear factor kappalight-chain-enhancer of activated B cells; OSCC, oral squamous cell carcinoma; siRNA, small interfering RNA; TCGA, the cancer genome atlas; uPA, urokinase plasminogen activator; VEGF, vascular endothelial growth factorOral squamous cell carcinoma is a highly malignant tumor with the potential to invade local and distant sites and promote lymph node metastasis. Major players underlying the molecular mechanisms behind tumor progression are yet to be fully explored. Migration and invasion enhancer 1 (MIEN1), a novel protein overexpressed in various cancers, facilitates cell migration and invasion. In the present study we investigated the expression and role of MIEN1 in oral cancer progression using an in vitro model, patient derived oral tissues and existing TCGA data. Expression analysis using immortalized normal and cancer cells demonstrated increased expression of MIEN1 in cancer. Assays performed after MIEN1 knockdown in OSC-2 cells showed decreased migration, invasion and filopodia formation; while MIEN1 overexpression in DOK cells increased these characteristics and also up-regulated some Akt/NF-kB effectors, thereby suggesting an important role for MIEN1 in oral cancer progression. Immunohistochemical staining and analyses of oral tissue specimens, collected from patients over multiple visits, revealed significantly more staining in severe dysplasia and squamous cell carcinoma compared to mildly dysplastic or hyperplastic tissues. Finally, this was corroborated with the TCGA dataset, where MIEN1 expression was not only higher in intermediate and high grade cancer with significantly lower survival but also correlated with smoking. In summary, we demonstrate that MIEN1 expression not only positively correlates with oral cancer progression but also seems to be a critical molecular determinant in migration and invasion of oral cancer cells, thereby, playing a possible role in their metastatic dissemination.

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“…The factors such as forkhead box (FoxOs) family members induce the expression of genes controlling defence against OS and promote cell survival by inhibiting cyclin in cell cycle. The stage of PD, linked to smoking, may be a critical marker of a susceptible immune system, also initiating cancer risk by a prooxidant inflammatory profile (26,27,28).…”

Section: Discussionmentioning

confidence: 99%

“…Severity of the disease may be proportional to the intensity of smoking (7). In addition to PD (8,9,10), OS has been implicated in the pathogenesis of a number of diseases, such as diabetes mellitus, cardiovascular (11) and neurodegenerative diseases (12) and malignancies (13). The aim of this study was to evaluate OS in patients with different stages of PD and the influence of their smoking habits on OS.…”

Section: Introductionmentioning

confidence: 99%

Periodontal disease related to oxidative stress

Katerina¹,

Dejanova²,

Petrovska³

et al. 2013

Ser J Exp Clin Res

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Th e study evaluates oxidative stress (OS) in patients with diff erent stages of periodontal disease (PD) and the infl uence of their smoking habits on OS. PD is related to connective tissue infl ammation, which leads to deterioration of the supporting structures of the tooth. OS is a condition characterised by overproduction of free radicals (FR), SAŽETAK Ova studija se bavi procenom oksidativnog stresa (OS) kod pacijenata sa različitim stadijumima oboljenja paradoncijuma -paradontopatija (PD), i uticaja pušačkih navika pacijenata. PD je povezana sa zapaljenjem vezivnih tkiva koje uzrokuje oštećenje tkivnog oslonca zuba. OS je stanje koje nastaje usled prevelike produkcije slobodnih radikala (SR) koji mogu biti uključeni u patogenezu PD, uzrokujući oštećenje paradontalnih tkiva i drugih bliskih tkiva. Pacijenti su bili podeljeni u sledeće grupe: I -nepušači (n=45), II -pušači (n=45), koji su razvrstani na osnovu stadijuma PD na: blag (1), umeren (2), težak (3) i kontrolnu grupu (n=30). SR su određivani pomoću D-Roms testa, ukupni antioksidativni kapacitet (UAK) pomoću

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Oxidative Stress Induced Mechanisms in the Progression of Periodontal Diseases and Cancer: A Common Approach to Redox Homeostasis?

Cited by 29 publications

References 118 publications

Periodontal Disease and Breast Cancer: Prospective Cohort Study of Postmenopausal Women

Periodontal Disease and Breast Cancer: Prospective Cohort Study of Postmenopausal Women

MIEN1 promotes oral cancer progression and implicates poor overall survival

Periodontal disease related to oxidative stress

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