Oxidative Stress Induced by 30 Days of Mercury Exposure Accelerates Hypertension Development in Prehypertensive Young SHRs

Ronchetti, Graziele Zandominegue; Schereider, Ingridy Reinholz Grafites; Leal, Marcos André Soares; Peçanha, Giulia Alessandra Wiggers; Padilha, Alessandra Simão; Vassallo, Dalton Valentim

doi:10.1007/s12012-022-09769-z

Cited by 1 publication

(2 citation statements)

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“…Previous studies showed that exposure to low concentrations of Hg leads to vascular injury following the increase in peripheral vascular resistance that is associated with a higher risk of mortality (Lemos et al, 2012;Fardin et al, 2019;Simões et al, 2020;Ronchetti et al, 2022). Moreover, the increase of mortality in animals exposed to Hg may be associated with Hg binding to thiol groups of cardiac proteins, inducing maladaptive changes in channels that influence the action potentials and cardiac rhythm (Oliveira et al, 2019;Vassallo et al, 2019).…”

Section: Association Between Arrhythmias and Rosmentioning

confidence: 99%

“…These factors could potentially be influenced by elevated peripheral vascular resistance (Fardin et al, 2019;, despite the absence of clear evidence of increased blood pressure in all groups following 30 days of mercury exposure. Additionally, chronic exposure to Hg can induce increased blood pressure through phenylephrine, which is caused by a decrease in NO and an increase in ROS (Fardin et al, 2019;Ronchetti et al, 2022).…”

Section: Blood Pressure Changes After Mercury Exposition Followed By ...mentioning

confidence: 99%

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Chronic exposure to mercury increases arrhythmia and mortality post-acute myocardial infarction in rats

Bello,

Wilke,

Simões

et al. 2023

Front. Physiol.

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Introduction: Mercury (Hg) is a heavy metal that causes a variety of toxic effects in eukaryotic cells. Previous studies have reported detrimental effects of mercury toxicity in the cardiovascular system. Given the importance of understanding the relationship between Hg and cardiovascular disease, we sought to investigate if the Hg could worsen the myocardial repercussions following ischemic injury. We demonstrated that once mercury toxicity is established, it can influence the outcome of myocardial infarction (MI).Methods: Male Wistar rats received intramuscular injections of either saline (NaCl 0.9%) or mercuric chloride (HgCl2, first dose of 4.6 μg/kg, and subsequent doses of 0.07 μg/kg/day) for 4 weeks. Three weeks post-exposure, we induced transmural infarction in the left ventricle free wall through coronary artery occlusion surgery. Results: ECG recordings obtained from MI groups demonstrated alterations in the rhythm of the heartbeat/heart electrical activity, as expected, including ventricular extrasystoles and ventricular tachycardia. However, the MI group exposed to Hg (MI-Hg) exhibited augmented ventricular extrasystoles and ventricular tachycardia compared to the MI group. Also, Basckó coefficient revealed that the arrhythmic events—after MI—were aggravated by Hg exposure.Discussion: Our results indicate that the significantly increased mortality in MI-Hg groups when compared to MI (21%, MI vs 32%, MI-Hg) is correlated with greater occurrence of arrhythmias. In conclusion, this study further supports the idea that exposure to mercury (Hg) should be recognized as a significant risk factor that exacerbates the impact of cardiac ischemic injury, potentially leading to an increased mortality rate among patients experiencing acute MI.

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Section: Association Between Arrhythmias and Rosmentioning

confidence: 99%

Section: Blood Pressure Changes After Mercury Exposition Followed By ...mentioning

confidence: 99%

Chronic exposure to mercury increases arrhythmia and mortality post-acute myocardial infarction in rats

Bello,

Wilke,

Simões

et al. 2023

Front. Physiol.

Self Cite

View full text Add to dashboard Cite

show abstract

Oxidative Stress Induced by 30 Days of Mercury Exposure Accelerates Hypertension Development in Prehypertensive Young SHRs

Cited by 1 publication

References 51 publications

Chronic exposure to mercury increases arrhythmia and mortality post-acute myocardial infarction in rats

Chronic exposure to mercury increases arrhythmia and mortality post-acute myocardial infarction in rats

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