Oxidative Stress Indicators in Patients with Prostate Disorders in Enugu, South-East Nigeria

Duru, Romanda; Njoku, O. U.; Maduka, Ignatius C

doi:10.1155/2014/313015

Cited by 20 publications

(20 citation statements)

References 25 publications

(30 reference statements)

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“…The oxidative damage can be exacerbated by a decreased efficiency of antioxidant defense mechanisms [ 9 ]. Like many different cancer types, OS has been linked with benign prostatic hyperplasia (BPH) and prostate cancer (PCa) development, progression and the response to therapy [ 10 – 14 ]. OS and PCa are both associated with increasing age because PCa is more prevalent in older men.…”

Section: Introductionmentioning

confidence: 99%

“…Several mechanisms for prostate hyperplasia development have been suggested and these include; oxidative stress (OS) [ 10 – 14 ], inflammatory mediators [ 3 , 16 – 20 ], hormones (especially androgens whose increase in physiologic level can cause increase in oxidative stress and alterations in intracellular glutathione levels and the activity of other detoxification enzymes required for the maintenance of the cellular prooxidant-antioxidant balance such as gamma-glutamyl transpeptidase) [ 15 ], enzymatic factors, dietary factors [ 21 – 23 ], inflammatory genes [ 17 , 24 ] and Gleason score grading system (Fig. 1 ) which is used to evaluate the prognosis of PCa [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Also, an inhibition of cell proliferation, migration, and invasion has been associated with SOD3 overexpression in PC-3 cell line [ 22 ]. Generally, PCa is accompanied with a decrease in serum level of anti-oxidants such as GPX, GSH-Px, SOD [ 14 , 35 ], and an increase in concentrations of thiobarbituric acid reactive substances (TBARS) [ 36 ] and lipid peroxidation byproducts [ 11 ]. Thioredoxin 1 (Trx 1), is another enzyme which acts as a subcellular indicator of redox status in PCa and has demonstrated that both endogenous and exogenous antioxidants are involved in determining how PCa progresses.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Oxidative stress in prostate hyperplasia and carcinogenesis

Udensi

Tchounwou

2016

J Exp Clin Cancer Res

124

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Prostatic hyperplasia (PH) is a common urologic disease that affects mostly elderly men. PH can be classified as benign prostatic hyperplasia (BPH), or prostate cancer (PCa) based on its severity. Oxidative stress (OS) is known to influence the activities of inflammatory mediators and other cellular processes involved in the initiation, promotion and progression of human neoplasms including prostate cancer. Scientific evidence also suggests that micronutrient supplementation may restore the antioxidant status and hence improve the clinical outcomes for patients with BPH and PCa. This review highlights the recent studies on prostate hyperplasia and carcinogenesis, and examines the role of OS on the molecular pathology of prostate cancer progression and treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative stress in prostate hyperplasia and carcinogenesis

Udensi

Tchounwou

2016

J Exp Clin Cancer Res

124

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“…The oxidative damage can be exacerbated by a decreased efficiency of antioxidant defense mechanisms, [6]. Like many different cancer types, OS has been linked with benign prostatic hyperplasia (BPH) and prostate cancer (PCa) development, progression and the response to therapy, [7,8,9,10]. OS and PCa are both associated with increasing age because PCa is more prevalent in older men.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Antioxidant Effects of Aqueous and Ethanolic Extracts of Zingiber officinale Rhizome in Testosterone Induced Benign Prostatic Hyperplasia Rat Model

Obisike

Boisa

Nwachuku

et al. 2019

JOCAMR

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Aims:To assess the antioxidant effects of the aqueous and ethanolic extracts of Ginger rhizome in testosterone induced prostate hyperplasic male rats. Study Design: The study was a cross-sectional study. Place and Duration of Study: The experimental aspect of this study was conducted at the animal house, Department of Pharmacology, University of Port Harcourt between April and September, 2019. Methodology: Sixty (60) adult albino male wistar rats were used for this study. They were divided into 12 groups of 5 rats each and fed with commercial rat diet and clean drinking water. Aqueous and ethanolic extractions of Ginger rhizome seed were prepared using the maceration method. BPH was induced in rats after they submitted to bilateral orchiectomy by daily injections of Obisike et al.; JOCAMR, 8(2): 1-12, 2019; Article no.JOCAMR.52835 2 testosterone propionate (TP) (4 mg/kg b.wt.sc). Rats were treated with 500 or 1500 mg/kg b.wt. of aqueous or ethanoI extracts of Zingiber officinale (Zo) rhizome, dutasteride or in combination. Administration of extracts was done by gavage. Plasma total oxidant status (TOS), total antioxidant status (TAS), superoxide dismutase (SOD) activity, were analysed using sandwich ELISA Kits by Shanghai Korain Biotech Co., Ltd, China, while oxidative stress indices (OSI) were calculated. Statistical analysis was done using SPSS version 22.0 of Windows Stat Pac and p values <0.05 were considered statistically significant. Results: The results showed that exogenous induction of BPH in rats significantly increased (p=0.000) plasma TOS and OSI while TAS and SOD activities were reduced. However, 500 and 1500 mg/kg b.wt. of Zo rhizome administered orally after exogenous induction of BPH had been established for 15 days, significantly decreased (p=0.000) TOS, OSI and significantly improved the activities of antioxidant parameters like SOD and TAS. Non-significantly increased mean TAS and SOD were seen in a combination of both extracts with dutasteride, possibly suggestive of synergistic interaction between the herbs and the drug. Simultaneous administration of aqueous and ethanolic extracts of Zo rhizome with TP for 30 days also showed antioxidant qualities, although the effects were statistically not better than values for treatments done when BPH was established before treatment. Ethanolic extracts of Zo rhizome produced better antioxidant effects compared to the aqueous extracts. Conclusion: From the findings, we conclude that Zo rhizome can ameliorate oxidative stress and therefore may be beneficial in the management of benign prostatic hyperplasia. Original Research Article

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“…5 Some previous reports have revealed high prevalence of prostate cancer in Nigeria; with prevalence rates of 127/100,000 men in 1997 and 114/100,000 men in 2002. 6,7 Prostate cancer is the commonest cancer among Nigerian males and has been estimated to constitute 13.3% of all male cancers. 8 It has been documented that the serum levels of PSA is widely used as a biomarker for early detection of prostate complications and its elevation in the serum is suggestive of prostate disorders.…”

Section: Introductionmentioning

confidence: 99%

Serum Trace Elements and Antioxidant Vitamins among Male Patients with Prostate Disorders in the Delta Region of Nigeria

Aghawegbehe¹,

Atere

Akinbo

et al. 2019

amj

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Background: Prostate cancer remains the commonest form of cancer among Nigerian males, constituting 13.3% of all male cancers encountered in this region. Trace elements and antioxidant vitamins may be of epidemiological significance in the early prediction and treatment of prostate complications. The study aimed to explore the serum trace elements, antioxidant vitamins concentration and serum prostate specific antigen (PSA) among male with prostate disorders in the delta region of Nigeria. Methods: Blood specimens were collected from males with symptoms of prostatitis (n=70), benign prostatic hyperplasia (BPH; n=60) and prostate cancer (PCa; n=70), alongside with apparently healthy male subjects (n=60). The levels of trace elements and antioxidant vitamins were evaluated. Fluorescence immunoassay technique was used to assess the expression of PSA. Results: Compared with the controls, PCa patients had a significantly increased level of vitamin A (p<0.05), however, no significant differences in the serum levels of trace elements and antioxidant vitamins between subjects with prostate disorders and control group (p>0.05). Interestingly, there was a significant positive correlation between prostate specific antigen, trace elements and vitamins in BPH group (p<0.05). Conclusions: Prostate disorders such as prostatitis, BPH and PCa may be associated with elevated levels of PSA, but, does not affect the circulating expression of some serum trace elements and antioxidant vitamins.

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Oxidative Stress Indicators in Patients with Prostate Disorders in Enugu, South-East Nigeria

Cited by 20 publications

References 25 publications

Oxidative stress in prostate hyperplasia and carcinogenesis

Oxidative stress in prostate hyperplasia and carcinogenesis

Assessment of Antioxidant Effects of Aqueous and Ethanolic Extracts of Zingiber officinale Rhizome in Testosterone Induced Benign Prostatic Hyperplasia Rat Model

Serum Trace Elements and Antioxidant Vitamins among Male Patients with Prostate Disorders in the Delta Region of Nigeria

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