Oxidative Stress Index Predicts the Severity of COVID-19

Zeliger, Harold I.; Kahaner, Harvey

doi:10.24018/ejmed.2020.2.4.369

Cited by 2 publications

(9 citation statements)

References 4 publications

(7 reference statements)

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“…The number of prevalent diseases at the time of OSI measurement is a critical indicator of OS. It is well established that all disease increases OS and hence the OSI (Zeliger, 2016;Zeliger 2017). All diseases have symptoms associated with them.…”

Section: ) Chronic Prevalent Diseasesmentioning

confidence: 99%

“…The OSI as originally developed contains 400+ items that address all causes of OS enumerated above. The number of positive items checked add up to the OSI and the higher the OSI, the greater the likelihood of disease onset (Zeliger, 2017). Since its original publication, the OSI has been applied to predicting causes of specific disease, carrying out public health surveys to asses the impact of proximate chemical discharges, health prescreening and limited medical care area screening (Zeliger 2019).…”

Section: B Oxidative Stress Index (Osi)mentioning

confidence: 99%

“…The scoring assignments for the individual parameters in the condensed form are based upon experience with the detailed OSI form. The point values assigned to each parameter are based upon those obtained via the detailed OSI questionnaire (Zeliger, 2017).…”

Section: Condensed Osi Formmentioning

confidence: 99%

“…For one aged 40-49, one OSI point is added to his or her total, 2 points are added for one aged 50-59, etc. (Zeliger, 2017).…”

Section: ) Agementioning

confidence: 99%

“…Oxidative stress (OS), a state of imbalance between free radicals and antioxidants in the body, is well known as a direct cause of non-communicative (environmental) disease as well as an indirect cause of bacterial and viral-causing disease via undermining of the immune system (Zeliger, 2016;Rajah & Chow, 2015;Zaki, et al, 2005). The Oxidative Stress Index (OSI), a non-invasive, questionnairebased index which numerically quantifies OS, has been shown to be an indicator of the environmental disease severity (Zeliger, 2017). It is proposed here that the OSI can be used to predict disease severity of communicative diseases such as COVID-19.…”

Section: Introductionmentioning

confidence: 99%

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Can the Oxidative Stress Index Predict the Severity of COVID-19?

Zeliger

Kahaner

2020

EJMED

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Severity of the COVID-19 disease ranges from imperceptible to death with the aged and those with pre-existing conditions being particularly vulnerable to severe symptoms. Other factors have also been shown to influence COVID-19 severity. These include smoking, vaping and exposure to air pollution. These factors have a one thing in common, all raise oxidative stress. The Oxidative Stress Index, derived from a questionnaire and reflective of oxidative stress level, is proposed as a non-invasive way to predict the severity of COVID-19 in those impacted by the Coronavirus.

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Section: ) Chronic Prevalent Diseasesmentioning

confidence: 99%

Section: B Oxidative Stress Index (Osi)mentioning

confidence: 99%

Section: Condensed Osi Formmentioning

confidence: 99%

“…For one aged 40-49, one OSI point is added to his or her total, 2 points are added for one aged 50-59, etc. (Zeliger, 2017).…”

Section: ) Agementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Can the Oxidative Stress Index Predict the Severity of COVID-19?

Zeliger

Kahaner

2020

EJMED

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Predicting Alzheimer's Disease Onset

Zeliger

2019

EJMED

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Recently, a method for assigning the probability of disease onset to all people, those clinically ill as well as those without prevalent disease has been described and termed the Oxidative Stress Index (OSI). The OSI, as originally formatted, does not predict which disease will more likely develop, only that further disease is predicted with increased OSI. It is hypothesized here that the OSI may be used to demonstrate which parameters are more contributory to the onset of a particular disease if it is measured at the time of onset of that disease. To test this hypothesis, the OSI has been reformatted to serve in that capacity for Alzheimer's disease (AD) with the anticipation that the OSI could serve to predict not only the likelihood of onset, but also identify those parameters that are most contributory to AD.

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Oxidative Stress Index Predicts the Severity of COVID-19

Cited by 2 publications

References 4 publications

Can the Oxidative Stress Index Predict the Severity of COVID-19?

Can the Oxidative Stress Index Predict the Severity of COVID-19?

Predicting Alzheimer's Disease Onset

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