Oxidative Stress in the Pathogenesis of Corneal Endothelial Dystrophies and Other Corneal Diseases

Guha, Sanjukta; Chaurasia, Sunita; Roy, Sanhita

doi:10.20455/ros.2018.857

Cited by 4 publications

(4 citation statements)

References 70 publications

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“…On exposure to oxidative stress, the Keap1 structure changes, allowing Nrf2 to detach from Keap1 and translocate into the nucleus. After translocation into the nucleus, Nrf2 binds to ARE and enhances downstream antioxidant gene expression to maintain the redox balance in cells [ 17 ]. The Nrf2 nuclear translocation and ARE transactivation processes are regulated by multiple pathways including protein kinase C (PKC), phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/GSK-3 β , p38 mitogen-activated protein kinase (MAPK), and nuclear factor kappa B (NF- κ B).…”

Section: Resultsmentioning

confidence: 99%

Effects of Acupuncture on Oxidative Stress Amelioration via Nrf2/ARE-Related Pathways in Alzheimer and Parkinson Diseases

Huang

Hsieh

2021

Evidence-Based Complementary and Alternative Medicine

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Oxidative stress is responsible for the pathogeneses of various diseases. Mitochondrial dysfunction, impaired DNA repair, and cellular damage followed by oxidative stress contribute to neurodegenerative diseases, such as Alzheimer disease (AD) and Parkinson disease (PD). Acupuncture is a traditional therapy that has been practiced for >3000 years in Asia. Many studies have demonstrated that acupuncture has notable antioxidative, anti-inflammatory, and antiapoptotic effects. However, the exact mechanism remains unclear. Nuclear factor erythroid 2-related factor (Nrf2) is crucial in regulating the redox equilibrium. Activated Nfr2 translocates into the nucleus, binds to the antioxidant response element (ARE), and initiates antioxidative enzyme transcription. In this review, we demonstrated the effects of acupuncture on oxidative stress amelioration in AD and PD animal models through Nrf2/ARE pathway activation and Nrf2/ARE-related pathway regulation. Thus, acupuncture could be a therapeutic option for AD and PD.

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Section: Resultsmentioning

confidence: 99%

Effects of Acupuncture on Oxidative Stress Amelioration via Nrf2/ARE-Related Pathways in Alzheimer and Parkinson Diseases

Huang

Hsieh

2021

Evidence-Based Complementary and Alternative Medicine

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“…In that case, the eye condition had been ongoing for more than 2 weeks, whereas clinical signs in the other two were only evident for 1-2 days. Previous papers have reported an increase in local oxidative damage (including MDA) in corneal tissue and aqueous humor from corneal diseases in humans [127][128][129], so this biomarker could be informative, as eye problems are common in captive elephants [6,130].…”

Section: Discussionmentioning

confidence: 99%

Measures of Oxidative Status Markers in Relation to Age, Sex, and Season in Sick and Healthy Captive Asian Elephants in Thailand

Kosaruk

Brown

Towiboon

et al. 2023

Animals

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Oxidative stress is a pathological condition that can have adverse effects on animal health, although little research has been conducted on wildlife species. In this study, blood was collected from captive Asian elephants for the assessment of five serum oxidative status markers (reactive oxygen species (ROS) concentrations; malondialdehyde, MDA; albumin; glutathione peroxidase, GPx; and catalase) in healthy (n = 137) and sick (n = 20) animals. Health problems consisted of weakness, puncture wounds, gastrointestinal distress, eye and musculoskeletal problems, and elephant endotheliotropic herpesvirus hemorrhagic disease (EEHV-HD). Fecal samples were also collected to assess glucocorticoid metabolites (fGCMs) as a measure of stress. All data were analyzed in relation to age, sex, sampling season, and their interactions using generalized linear models, and a correlation matrix was constructed. ROS and serum albumin concentrations exhibited the highest concentrations in aged elephants (>45 years). No sex differences were found for any biomarker. Interactions were observed for age groups and seasons for ROS and catalase, while GPx displayed a significant interaction between sex and season. In pairwise comparisons, significant increases in ROS and catalase were observed in summer, with higher ROS concentrations observed only in the adult female group. Lower catalase activity was exhibited in juvenile males, subadult males, adult females, and aged females compared to subadult and adult elephants (males and females) in winter and the rainy season. There was a positive association between catalase activity and fGCMs (r = 0.23, p < 0.05), and a number of red blood cell parameters were positively associated with several of these biomarkers, suggesting high oxidative and antioxidative activity covary in red cells (p < 0.05). According to health status, elephants with EEHV-HD showed the most significant changes in oxidative stress markers, with MDA, GPx, and catalase being higher and albumin being lower than in healthy elephants. This study provides an analysis of understudied health biomarkers in Asian elephants, which can be used as additional tools for assessing the health condition of this species and suggests age and season may be important factors in data interpretation.

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“…It was found that vitamin D supplementation independently and significantly up‐regulates GCL and GR expression. As a result, there are increased levels of GSH in vitamin D‐treated cells and significantly lowered ROS levels in cells exposed to both control and high levels of glucose 94–96 . Studies on inflammation in adults and other chronic illnesses like tuberculosis found strong associations of vitamin D concentrations with higher GSH levels leading to the same conclusion that vitamin D up‐regulates GCL and GR to increase cellular glutathione formation 85 .…”

Section: Vitamin D and Its Effects On The Biosynthesis Of Cysteine And Glutathionementioning

confidence: 99%

Vitamin D and COVID‐19: A review on the role of vitamin D in preventing and reducing the severity of COVID‐19 infection

et al. 2021

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Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) is a pathogenic coronavirus causing COVID‐19 infection. The interaction between the SARS‐CoV‐2 spike protein and the human receptor angiotensin‐converting enzyme 2, both of which contain several cysteine residues, is impacted by the disulfide‐thiol balance in the host cell. The host cell redox status is affected by oxidative stress due to the imbalance between the reactive oxygen/nitrogen species and antioxidants. Recent studies have shown that Vitamin D supplementation could reduce oxidative stress. It has also been proposed that vitamin D at physiological concentration has preventive effects on many viral infections, including COVID‐19. However, the molecular‐level picture of the interplay of vitamin D deficiency, oxidative stress, and the severity of COVID‐19 has remained unclear. Herein, we present a thorough review focusing on the possible molecular mechanism by which vitamin D could alter host cell redox status and block viral entry, thereby preventing COVID‐19 infection or reducing the severity of the disease.

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Oxidative Stress in the Pathogenesis of Corneal Endothelial Dystrophies and Other Corneal Diseases

Cited by 4 publications

References 70 publications

Effects of Acupuncture on Oxidative Stress Amelioration via Nrf2/ARE-Related Pathways in Alzheimer and Parkinson Diseases

Effects of Acupuncture on Oxidative Stress Amelioration via Nrf2/ARE-Related Pathways in Alzheimer and Parkinson Diseases

Measures of Oxidative Status Markers in Relation to Age, Sex, and Season in Sick and Healthy Captive Asian Elephants in Thailand

Vitamin D and COVID‐19: A review on the role of vitamin D in preventing and reducing the severity of COVID‐19 infection

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