Oxidative Stress in the Heart of Rats with Diabetic Nephropathy treated with Esculin

Rodrigues, Inri; Punaro, Giovana Rita; Lima, Deyse Y.; Bessa, Tiphany De; Mouro, Margaret Gori; Bertolini, A.; Rodrigues, Adelson Marçal; Serralha, Robson; Higa, Elisa Mieko Suemitsu

doi:10.1016/j.freeradbiomed.2020.10.193

Cited by 2 publications

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“…Diabetes is a chronic metabolic illness defned by high blood glucose levels, or hyperglycemia, which is typically caused by a lack of insulin secretion and/or insulin hormone action in pancreatic beta cells [1]. Diabetes is seen as a health threat in both developed and developing countries.…”

Section: Introductionmentioning

confidence: 99%

TNF-α and IL-1β in Diabetes-Induced Liver Damage: The Relationship between Trachyspermum ammi Seeds Methanol Extract and Inflammatory Cytokine Inhibition

Zolfaghari

Monajemi

Shahanipour

et al. 2023

Journal of Food Biochemistry

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The objective of this study was to determine the effect of Trachyspermum ammi (T. ammi) on the liver of streptozotocin (STZ)-induced diabetic rats. This study began by identifying the methanolic composition of T. ammi. The presence of three compounds was determined using gas chromatography-mass spectrometry (GC-MS), with Thymol (60.705%), ϒ-Terpinene (22.216%), and P-cymene (17.078%) being the most prevalent. Afterwards, diabetic rats were treated with T. ammi (200–500 mg/kg) or losartan (20 mg/kg) daily for 60 days. In the diabetic rats treated with T. ammi, levels of hepatic indicators, lipid peroxidation markers, and proinflammatory mediators decreased significantly. In the liver of T. ammi-treated diabetic rats, glutathione-S-transferase (GST), catalase (CAT), and glutathione (GSH) increased significantly. Despite the fact that proinflammatory cytokine levels were significantly increased, interleukin-1β (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels decreased in the groups administered the extract. From these results, it can be concluded that T. ammi significantly restored the liver’s antioxidant balance and inflammation caused by hyperglycemia.

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Section: Introductionmentioning

confidence: 99%

TNF-α and IL-1β in Diabetes-Induced Liver Damage: The Relationship between Trachyspermum ammi Seeds Methanol Extract and Inflammatory Cytokine Inhibition

Zolfaghari

Monajemi

Shahanipour

et al. 2023

Journal of Food Biochemistry

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Preparation, Pharmacokinetics and Anti-Liver Injury Pharmacodynamic Study of Esculin Loaded Liposomes Modified by TPGS

Shi,

Sun,

Yin

et al. 2024

j biomed nanotechnol

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In this study, Esculin (ES)-loaded liposomes modified with TPGS (ES-TPGS-Ls) were successfully prepared to enhance bioavailability and hepatoprotective activity of this coumarin glucoside. We utilize thin-film dispersion to fabricate ES-TPGS-Ls. The size, polydispersed index (PDI), Zeta potential (Z-potential), morphology, and encapsulation effectiveness of the liposomes were all evaluated afterwards. The storage stability of ES-TPGS-Ls at 4 °C was investigated. The findings showed that ES-TPGS-Ls had spherical nanoparticles with 194.47±8.54 nm as the mean size, 0.239±0.011 as PDI, and −21.16±0.97) mV as Z-potential coupled with encapsulation efficiency (EE) of 91.85±0.44%. Storage stability of liposomes at 4 °C was maintained within one week. Pharmacokinetic study showed that the relative oral bioavailability of ES-TPGS-Ls increased by 2.38 times. Pharmacodynamic studies showed that the developed liposomes could enhance the hepatoprotective activity of ES. Overall, the ES-TPGS-Ls significantly enhanced the bioavailability of esculin, thereby enhancing the in vivo hepatoprotective effect of ES.

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Oxidative Stress in the Heart of Rats with Diabetic Nephropathy treated with Esculin

Cited by 2 publications

References 0 publications

TNF-α and IL-1β in Diabetes-Induced Liver Damage: The Relationship between Trachyspermum ammi Seeds Methanol Extract and Inflammatory Cytokine Inhibition

TNF-α and IL-1β in Diabetes-Induced Liver Damage: The Relationship between Trachyspermum ammi Seeds Methanol Extract and Inflammatory Cytokine Inhibition

Preparation, Pharmacokinetics and Anti-Liver Injury Pharmacodynamic Study of Esculin Loaded Liposomes Modified by TPGS

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