Oxidative stress in the brain–lung crosstalk: cellular and molecular perspectives

Kong, Jianda; Fan, Rao; Zhang, Yuanqi; Jia, Zixuan; Zhang, Jing; Pan, Huixin; Wang, Qinglu

doi:10.3389/fnagi.2024.1389454

Cited by 3 publications

(1 citation statement)

References 124 publications

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“…Overall, these findings underscore the importance of monitoring MDA levels as a marker for oxidative stress and its potential implications in biological systems (Bencivenga et al, 2023;Wróbel-Nowicka et al, 2024;Kong et al, 2024;Valavanidis et al, 2006). Further research may delve into elucidating the specific factors contributing to the observed increase in MDA levels in the control (+) group, leading to a better understanding of the underlying mechanisms and potential therapeutic interventions to mitigate oxidative stress-related damage.…”

Section: Figure 1 Mda Standard Curvementioning

confidence: 74%

Linking MDA Levels and Blood Glucose in Streptozotocin-Induced Rat Diabetes: Implications for Diabetic Complications and Therapeutic Strategies

Angie,

Girsang,

Ikhtiari

2024

jppipa, pendidikan ipa, fisika, biologi, kimia

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Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels resulting from insulin deficiency or resistance. Streptozotocin, a potent diabetogenic agent, is commonly employed to induce experimental diabetes by selectively damaging pancreatic beta cells, resulting in insulin deficiency and hyperglycemia. Elevated Malondialdehyde (MDA) levels, indicative of oxidative stress and lipid peroxidation, are closely linked to diabetic complications. This study aimed to investigate the association between MDA levels and blood glucose in Streptozotocin-induced rat diabetes, shedding light on potential therapeutic strategies. Spectrophotometric analysis was utilized to quantify MDA levels in rat tissues, providing insights into the extent of oxidative damage. The results revealed a significant correlation between MDA levels and blood glucose, highlighting the role of oxidative stress in diabetic pathogenesis. These findings underscore the importance of targeting oxidative stress in diabetes management to prevent complications. In conclusion, the study emphasizes the relevance of monitoring MDA levels as a biomarker for assessing oxidative stress in diabetic conditions and guiding therapeutic interventions.

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Section: Figure 1 Mda Standard Curvementioning

confidence: 74%

Linking MDA Levels and Blood Glucose in Streptozotocin-Induced Rat Diabetes: Implications for Diabetic Complications and Therapeutic Strategies

Angie,

Girsang,

Ikhtiari

2024

jppipa, pendidikan ipa, fisika, biologi, kimia

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Reactive Oxygen Species Mechanisms that Regulate Protein–Protein Interactions in Cancer

Iliadis,

Papanikolaou

2024

IJMS

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Reactive oxygen species (ROS) are produced during cellular metabolism and in response to environmental stress. While low levels of ROS play essential physiological roles, excess ROS can damage cellular components, leading to cell death or transformation. ROS can also regulate protein interactions in cancer cells, thereby affecting processes such as cell growth, migration, and angiogenesis. Dysregulated interactions occur via various mechanisms, including amino acid modifications, conformational changes, and alterations in complex stability. Understanding ROS-mediated changes in protein interactions is crucial for targeted cancer therapies. In this review, we examine the role that ROS mechanisms in regulating pathways through protein–protein interactions.

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Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Nunes,

Mendes,

Pereira de Lima

et al. 2024

Nutrients

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Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, and mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant and anti-inflammatory properties, has emerged as a promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms of curcumin’s effects and the optimal dosages for different conditions necessitate further investigation. This systematic review synthesizes current evidence on curcumin’s potential in addressing age-related disorders, emphasizing its impact on cognitive function, neurodegeneration, and muscle health in older adults. By evaluating the safety, efficacy, and mechanisms of action of curcumin supplementation, this review aims to provide insights into its therapeutic potential for promoting healthy aging. A systematic search across three databases using specific keywords yielded 2256 documents, leading to the selection of 15 clinical trials for synthesis. Here, we highlight the promising potential of curcumin as a multifaceted therapeutic agent in combating age-related disorders. The findings of this review suggest that curcumin could offer a natural and effective approach to enhancing the quality of life of aging individuals. Further research and well-designed clinical trials are essential to validate these findings and optimize the use of curcumin in personalized medicine approaches for age-related conditions.

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Oxidative stress in the brain–lung crosstalk: cellular and molecular perspectives

Cited by 3 publications

References 124 publications

Linking MDA Levels and Blood Glucose in Streptozotocin-Induced Rat Diabetes: Implications for Diabetic Complications and Therapeutic Strategies

Linking MDA Levels and Blood Glucose in Streptozotocin-Induced Rat Diabetes: Implications for Diabetic Complications and Therapeutic Strategies

Reactive Oxygen Species Mechanisms that Regulate Protein–Protein Interactions in Cancer

Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

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