Oxidative stress in Strongylus spp. infected donkeys treated with piperazine citrate versus doramectin

Elmeligy, Enas; Abdelbaset, Abdelbaset Eweda; Elsayed, Hanan K.; Bayomi, Sara A; Hafez, Alaa El-Din Sayed; Abu‐Seida, Ashraf M.; El-Khabaz, Khaled A. S.; Hassan, Dalia; Ghandour, Rehab A.; Khalphallah, Arafat

doi:10.5455/ovj.2021.v11.i2.8

Cited by 7 publications

(7 citation statements)

References 32 publications

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“…The present study revealed that P. equorum inoculation signi cantly caused an elevation in the MDA and NO levels. Presence of parasitic infections destroyed the tissue, lipid peroxidation took place in a large volume, MDA as the most important product of this process elevated and fascinated demolition of cell structures, in ammation and necrosis (Elmeligy, et al, 2021). In the same line, (Nazarlu, et al, 2020) reported that invasion of Toxoplasma parasite induces NO production by macrophages to maintain the viability of the cell during its residence.…”

Section: Discussionmentioning

confidence: 96%

“…Lipid peroxidation (LP) is a complex chain reaction that is created by free oxygen radicals in uencing unsaturated fatty acids in cell membranes, leading to their damage. Therefore, LP is the best indicator of ROS levels that induced systemic biological damage (Elmeligy, et al, 2021). Estimation of malondialdehyde (MDA) level evaluates the degree of LP and the level of ROS indirectly as MDA is the end product of lipid peroxidation (Alatar & Abbas, 2021).…”

Section: Discussionmentioning

confidence: 99%

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Anthelmintic and hepatoprotective activities of the biocompatible Zinc Oxide Nanoparticles against Parascaris equorum infection in rats

Ali

Mohamed

Fahmy

et al. 2022

Preprint

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Background: Nanoparticles have many properties, depending on their size, shape, and morphology, allowing them to interact with microorganisms, plants, and animals. Objectives: Investigatation of the therapeutic effects biocompatible zinc oxide nanoparticles (ZnO NPs) on P. equorum infection in rats. Methods: Thirty-six rats were divided into two divisions are: the first division is noninfected groups were allocated into three groups. Group 1: Control, Group 2: ZnO NPs (30mg/kg) and group 3: ZnO NPs (60mg/kg). The second division is infected groups were allocated into three groups. Group 1: vehicle, group 2: ZnO NPs (30mg/kg) and group 3: ZnO NPs (60mg/kg). Findings: Biocompatible ZnO NPs caused a significant decrease in liver functions, LDL, cholesterol, triglycerides, MDA and NO. While it caused a significant increase in HB, HDL, BCHE, GSH, CAT, and GST in infected treated rats. The histological inflammation and fibroplasia scores showed a significant enhancement during the treatment with ZnO NPs (30, 60mg/kg) compared to the infected untreated animals that scored the highest pathological destruction score. Immunohistochemical markers of NF-κB showed a significant decrease during the treatment with ZnO NPs (30, 60mg/kg) compared to the infected untreated animals. Main conclusions: Biocompatible Zinc Oxide Nanoparticle is a promising treatment modality against parasitic infection through its powerful anthelmintic, antioxidant, healing promotion, and anti-inflammation effects.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Anthelmintic and hepatoprotective activities of the biocompatible Zinc Oxide Nanoparticles against Parascaris equorum infection in rats

Ali

Mohamed

Fahmy

et al. 2022

Preprint

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show abstract

“…Lipid peroxidation (LP) is a complex chain reaction that is created by free oxygen radicals influencing unsaturated fatty acids in cell membranes, leading to their damage. Therefore, LP is the best indicator of ROS levels that induced systemic biological damage [ 54 ]. Estimation of malondialdehyde (MDA) level evaluates the degree of LP and the level of ROS indirectly as MDA is the end product of lipid peroxidation [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Anthelmintic and Hepatoprotective Activities of the Green-Synthesized Zinc Oxide Nanoparticles Against Parascaris equorum Infection in Rats

Ali,

Mohamed,

Fahmy

et al. 2023

Acta Parasit.

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Main conclusions Green-synthesized zinc oxide nanoparticle is a promising treatment modality against parasitic infection through its powerful anthelmintic, antioxidant, healing promotion, and anti-inflammation effects. Background Nanoparticles have many properties, depending on their size, shape, and morphology, allowing them to interact with microorganisms, plants, and animals. Objectives Investigation of the therapeutic effects of green-synthesized zinc oxide nanoparticles (ZnO NPs) on Parascaris equorum infection in rats. Methods Thirty-six rats were divided into two divisions: the first division is noninfected groups were allocated into three groups. Group 1: Control, group 2: ZnO NPs (30 mg/kg), and group 3: ZnO NPs (60 mg/kg). The second division is infected groups were allocated into three groups. Group 1: vehicle, group 2: ZnO NPs (30 mg/kg), and group 3: ZnO NPs (60 mg/kg). Findings Ten days post-infection, two larvae per gram of liver tissue were present in the vehicle group compared to the control group. No larvae were recovered from ZnO NPs (30 mg/kg), and one larva/g.tissue from ZnO NPs (60 mg/kg)-treated groups compared to untreated infected animals. Green-synthesized ZnO NPs caused a significant decrease in liver functions, low-density lipoprotein (LDL), cholesterol, triglycerides, malondialdehyde (MDA), and nitric oxide (NO). While it caused a significant increase in hemoglobin (HB), high-density lipoprotein (HDL), butyrylcholinesterase (BCHE), glutathione (GSH), catalase (CAT), and glutathione S-transferase (GST) in infected treated rats. The histological inflammation and fibroplasia scores showed a significant enhancement during the treatment with ZnO NPs (30, 60 mg/kg) compared to the infected untreated animals that scored the highest pathological destruction score. Immunohistochemical markers of NF-κB showed a significant decrease during the treatment with ZnO NPs (30, 60 mg/kg) compared to the infected untreated animals.

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“…The oxidative status has also been studied in horses [25][26][27][28][29][30][31][32][33], and there are also a few studies on donkeys [34][35][36]. In horses, studies assessing oxidative status in relation to exercise reported higher concentrations of derived reactive oxygen metabolites (d-ROMs) after sub-maximal exercise on a treadmill, compared to rest [26,27].…”

Section: Introductionmentioning

confidence: 99%

“…In donkeys, the literature on the evaluation of the oxidative status is scarce. Oxidative stress has been evaluated in Strongylus spp.-infected donkeys, and the authors found higher concentrations of OS biomarkers before treatment [35]. Dietary supplementation with a natural polyphenol (verbascoside) has been reported to decrease ROM concentration and increase vitamin E levels in jennies and their suckling foals [36].…”

Section: Introductionmentioning

confidence: 99%

Maternal and Neonatal Evaluation of Derived Reactive Oxygen Metabolites and Biological Antioxidant Potential in Donkey Mares and Foals

Sgorbini¹,

Bonelli²,

Percacini³

et al. 2021

Animals

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Our aim was to measure the concentrations of derived reactive oxygen metabolite (d-ROMs) and biological antioxidant potential (BAP) of donkey mares and foals at delivery and to verify the protective role of the placenta against fetal oxidative stress. A total of 15 Amiata jennies with a physiological gestation length and delivery were included together with 17 foals (two twin foalings). After delivery, maternal and foal venous blood samples were collected along with blood from the artery. Circulating lactate and plasma d-ROMs and BAP were evaluated. The Wilcoxon test for paired data was applied to verify differences in d-ROMs and BAP values, while the Spearman test was used to evaluate correlations. A significantly higher d-ROMs concentration was found in jennies compared to their foals, and to the umbilical artery blood. The BAP was higher in jennies than in their foals, but no differences were observed in the umbilical artery blood. No difference was found between foals and their umbilical cord. Blood lactate was higher in foals than in their dams. Positive correlations were found between mares and umbilical cord for BAP and d-ROMs, and between mares and foals and umbilical cord for BAP. In conclusion, the placenta may be a protective factor for the fetus. As with equine foals, the antioxidant system of donkey foals does not seems to be effective at birth.

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Oxidative stress in Strongylus spp. infected donkeys treated with piperazine citrate versus doramectin

Cited by 7 publications

References 32 publications

Anthelmintic and hepatoprotective activities of the biocompatible Zinc Oxide Nanoparticles against Parascaris equorum infection in rats

Anthelmintic and hepatoprotective activities of the biocompatible Zinc Oxide Nanoparticles against Parascaris equorum infection in rats

Anthelmintic and Hepatoprotective Activities of the Green-Synthesized Zinc Oxide Nanoparticles Against Parascaris equorum Infection in Rats

Maternal and Neonatal Evaluation of Derived Reactive Oxygen Metabolites and Biological Antioxidant Potential in Donkey Mares and Foals

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