Oxidative stress in pregnant women with diabetes mellitus

Kapustin, Roman V.; Викторович, Капустин Роман; Arzhanova, Olga N.; Николаевна, Аржанова Ольга; Tiselko, Alena V.; Викторовна, Тиселько Алена

doi:10.14341/dm8669

Cited by 4 publications

(1 citation statement)

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“…При беременности, осложненной гестозом и СД возникает состояние окислительного стресса, связанное с повышением активности митохондрий в плаценте и увеличенной продукцией активных форм кислорода. Окислительный стресс при ГСД также ассоциирован с высокими уровнями лептина [28][29][30].…”

Section: обоснованиеunclassified

Arterial hypertension and diabetes developed in pregnancy

Zagarskikh

Partsernyak²,

Рищук³

et al. 2022

HERALD of North-Western State Medical University named after I.

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BACKGROUND: Gestational diabetes mellitus is a significant medical and social problem in most countries. Despite the relatively high level of development of modern medicine, following the growth of obesity and type 2 diabetes, the prevalence of gestational diabetes mellitus is also increasing worldwide. AIM: To identify the frequency and structure of carbohydrate metabolism disorders and to compare the level of blood pressure in a random sample of pregnant women registered in the Perinatal center. MATHERIALS AND METHODS: The analysis of the data of examination of carbohydrate metabolism of pregnant women who are registered in the Perinatal Center (Leningrad region, Gatchina), has been carried out. The analysis of medical documentation, survey, endocrinological and gynecological examination, calculation of the body mass index and the study of carbohydrate metabolism have been carried out. RESULTS: There is an increase in the number of pregnant women with impaired carbohydrate metabolism over the years of observation. Gestational diabetes on diet therapy was 64.4% in 2019, 31.0% in 2020, 65.1% in 2021, on insulin therapy 32.2, 62.3, 28.9% respectively. There was an increase in the number of women with type 1 and type 2 diabetes diagnosed before pregnancy and newly diagnosed diabetes during pregnancy. Body mass index and blood pressure levels are higher and glycated hemoglobin levels are lower in diet-treated pregnant women with gestational diabetes compared with insulin therapy. An increase in glycated hemoglobin was found annually in a group of women with gestational diabetes mellitus on insulin therapy. CONCLUSIONS: The high prevalence of carbohydrate metabolism disorders and the associated increase in blood pressure in pregnant women in Saint Petersburg and the Leningrad Region justifies a targeted search for carbohydrate metabolism disorders in pregnant women.

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Section: обоснованиеunclassified