Oxidative stress in patients with non-complicated malaria

Pabón, Adriana; Carmona, Jaime; Burgos, Luis C.; Blair, Silvia

doi:10.1016/s0009-9120(02)00423-x

Cited by 91 publications

(82 citation statements)

References 45 publications

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“…SOD upgrades endothelial cell damage triggered by adherent parasitized RBCs, underscoring their probable therapeutic benefit as endothelial cell protectors [19]. Pabon et al [20], have reported increase in SOD and glutathione peroxidase activity in patients with non-complicated malaria.…”

Section: Discussionmentioning

confidence: 97%

Changes in Levels of Antioxidant Markers and Status of Some Enzyme Activities among FalciparumMalaria Patients in Yemen

Ezzi

Salahy

Shnawa

et al. 2017

JMEN

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Clinical data indicate that oxidative stress and activities may play important roles in Plasmodium falciparum. The aim of this study was to assess the erythrocyte antioxidants and evaluate enzyme activities as marker for Plasmodium falciparum malaria patients. The diagnosis of malaria was confirmed by thick and thin film with Giemsa staining of malaria parasite. Ninety consenting individuals, sixty infected patients and thirty uninfected subjects comprising both sexes were randomly selected and age range between 18 to 48 years. The levels of Erythrocytic superoxide dismutase eSOD, serum ceruloplasmin (CP), vitamin C, alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were determined. Low levels of essential antioxidants such as eSOD and vitamin C in the patients have been found to be associated with an increased risk of Plasmodium falciparum malaria. Low levels of antioxidants observed in the falciparum malaria patients may be due to their increased utilization to free radical scavenger. High level of CP observed in the Plasmodium falciparum malaria patients may be of powerful potency against oxidative stress. Furthermore, lowered levels of antioxidants especially of vitamin C in malaria infection suggest that antioxidant may play a major role in the treatment of malaria infection. It was detected that serum levels of ALP and LDH were significantly higher in Plasmodium falciparum malaria patients group, compared with the healthy group. Higher levels of LDH and ALP in the Plasmodium falciparum malaria patients may be used in the diagnosis and treatment and monitoring of patients with malaria. Results also suggest that the rise in LDH activity may be as a result of the cellular anoxia of liver rather than other tissues in malaria patients.

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Section: Discussionmentioning

confidence: 97%

Changes in Levels of Antioxidant Markers and Status of Some Enzyme Activities among FalciparumMalaria Patients in Yemen

Ezzi

Salahy

Shnawa

et al. 2017

JMEN

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“…Patients with acute noncomplicated P. falciparum or P. vivax malaria have a lower catalase activity than noninfected individuals but a higher SOD activity (27). Reduced catalase activity, together with increased SOD activity, may result in the accumulation of H 2 O 2 .…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, neither the HO-1 inductor CoPPIX nor the inhibitor of HO-1 activity SnPPXI interfered with SOD activity, suggesting that the heme effect on SOD is not directly mediated by HO-1. Aside from playing a protective role during oxidative stress, SOD-1 activity has been linked to several inflammatory diseases and infections, including malaria (26,27,(51)(52)(53).…”

Section: Discussionmentioning

confidence: 99%

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Heme Impairs Prostaglandin E2 and TGF-β Production by Human Mononuclear Cells via Cu/Zn Superoxide Dismutase: Insight into the Pathogenesis of Severe Malaria

Andrade

Araújo-Santos

Luz

et al. 2010

The Journal of Immunology

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In many hemolytic disorders, such as malaria, the release of free heme has been involved in the triggering of oxidative stress and tissue damage. Patients presenting with severe forms of malaria commonly have impaired regulatory responses. Although intriguing, there is scarce data about the involvement of heme on the regulation of immune responses. In this study, we investigated the relation of free heme and the suppression of anti-inflammatory mediators such as PGE2 and TGF-β in human vivax malaria. Patients with severe disease presented higher hemolysis and higher plasma concentrations of Cu/Zn superoxide dismutase (SOD-1) and lower concentrations of PGE2 and TGF-β than those with mild disease. In addition, there was a positive correlation between SOD-1 concentrations and plasma levels of TNF-α. During antimalaria treatment, the concentrations of plasma SOD-1 reduced whereas PGE2 and TGF-β increased in the individuals severely ill. Using an in vitro model with human mononuclear cells, we demonstrated that the heme effect on the impairment of the production of PGE2 and TGF-β partially involves heme binding to CD14 and depends on the production of SOD-1. Aside from furthering the current knowledge about the pathogenesis of vivax malaria, the present results may represent a general mechanism for hemolytic diseases and could be useful for future studies of therapeutic approaches.

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“…Durante la infección de la malaria, tanto el parásito como el hospedero están bajo los efectos de estrés oxidativo, dado que se aumenta la producción de especies reactivas del oxígeno (ERO) (anión superóxido, peróxido de hidrógeno, radicales hidroxilo y ácido hipocloroso) 3,4 . El aumento de radicales libres en el organismo tiene como finalidad servir como mecanismo de tratamiento sobre los eritrocitos parasitados para inhibir la infección y destruir el parásito.…”

Section: Introductionunclassified

Evaluación del efecto genotóxico en pacientes con malaria de una región de Colombia

Cuesta

Martínez

Massaro

et al. 2014

Rev. chil. infectol.

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Oxidative stress in patients with non-complicated malaria

Cited by 91 publications

References 45 publications

Changes in Levels of Antioxidant Markers and Status of Some Enzyme Activities among FalciparumMalaria Patients in Yemen

Changes in Levels of Antioxidant Markers and Status of Some Enzyme Activities among FalciparumMalaria Patients in Yemen

Heme Impairs Prostaglandin E2 and TGF-β Production by Human Mononuclear Cells via Cu/Zn Superoxide Dismutase: Insight into the Pathogenesis of Severe Malaria

Evaluación del efecto genotóxico en pacientes con malaria de una región de Colombia

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