Oxidative stress in mice is dependent on the free glucose content of the diet

Folmer, Vanderlei; Soares, Júlio César Mendes; Rocha, João Batista Teixeira da

doi:10.1016/s1357-2725(02)00065-1

Cited by 94 publications

(53 citation statements)

References 43 publications

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“…Furthermore, it has been shown that d-ALA-D is significantly inhibited in hyperglycemic condition by glycation of its protein amino groups. 5,11,40) In line with this, in the present study we have observed that the hyperglycemia induced by alloxan caused a specific tissue inhibition of d-ALA-D activity. Furthermore, the enzyme activity varies according to the duration of the diabetic condition.…”

Section: Discussionsupporting

confidence: 89%

Acute Diphenyl Diselenide Treatment Reduces Hyperglycemia But Does Not Change Delta-Aminolevulinate Dehydratase Activity in Alloxan-Induced Diabetes in Rats

Barbosa

Oliveira

Araldi

et al. 2008

Biological & Pharmaceutical Bulletin

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Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in both insulin secretion and/or insulin action. Hyperglycemia, the primary clinical manifestation of diabetes mellitus, is associated with non enzymatic glycation of proteins and free radicals generation.1,2) These processes can cause protein cross-linking and damage in other biomolecules such as enzymes, lipids and DNA; contributing to the overall complications of diabetes mellitus. 3-7)d-Aminolevulinate dehydratase (d-ALA-D) is a sulfhydrylcontaining enzyme, involved in the formation of porphobilinogen, a heme precursor.8) d-ALA-D activity is highly sensitive to the presence of a variety of pro-oxidant agents and to situations associated with oxidative stress, which oxidize its -SH groups.9,10) Of note, in diabetic state the activity of d-ALA-D and the other enzymes of heme pathway are significantly inhibited.11,12) Consistent with these findings it has been reported that high levels of glucose also produce chemical alterations in other physiologically abundant proteins such as collagen, hemoglobin and albumin. 13,14) Thus, the interest in compounds that could potentially reduce the biological alterations associated with hyperglycemia is intense.Selenium is known to be an essential trace element that plays a crucial role as an integral component of several enzymes with antioxidant properties, including glutathione peroxidase. 15,16) Conversely, high doses of selenium can be toxic via its ability to catalyze the oxidation of thiols and to generate free radicals. 10,17) Of particular importance, this element because of its physiological antioxidant properties, exhibits a number of potentially beneficial effects against the development of different diseases 10,[18][19][20] including diabetes mellitus. [21][22][23][24] Moreover, the literature data have indicated that inorganic selenium compounds can attenuate the cytotoxic effects of hyperglycemia via its insulin-mimetic and anti-glycating properties. 25,26) On the other hand, data reported in the literature indicating the therapeutic benefit of synthetic organoselenium compounds in the treatment of diabetes are rare. 24,27,28) Diphenyl diselenide is the simplest of the diaryl diselenides and has glutathione peroxidase-like activity, exhibits antioxidant, hepatoprotective, antiulcer and anti-inflammatory properties.10,29,30) Importantly, a previous study from our research group showed that chronic administration of diphenyl diselenide, at low doses, reduces temporarily the hyperglycemia in streptozotocin-treated (STZ-treated) rats. 23)Thus, the aim of this study was to investigate whether acute treatment with diphenyl diselenide could ameliorate the diabetogenic effects induced by alloxan administration. Thereby, we examined the effect of diphenyl diselenide treatment before and after the diabetes induction, in order to determinate if the compound would act by preventing (pretreatment) and/or restoring (post-treatment) alloxan toxicity. Furthermore, the analy...

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Section: Discussionsupporting

confidence: 89%

Acute Diphenyl Diselenide Treatment Reduces Hyperglycemia But Does Not Change Delta-Aminolevulinate Dehydratase Activity in Alloxan-Induced Diabetes in Rats

Barbosa

Oliveira

Araldi

et al. 2008

Biological & Pharmaceutical Bulletin

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“…Whether this Snitrosation affects Pantophysin's role in GLUT translocation is expected for further research. (D) Aminolevulinate delta dehydratase (ALAD), its activity decreased in the liver of high glucose-induced diabetic rats (Folmer et al, 2002) and the oxidation of cysteines is thought to be one possible reason (Afonso et al, 1996). Here we found that S-nitrosation of ALAD increased 2.17 folds in diabetic mouse liver, suggesting one possible contribution to the decrease of ALAD activity.…”

Section: Discussionmentioning

confidence: 68%

Quantitative proteomic analysis of S-nitrosated proteins in diabetic mouse liver with ICAT switch method

et al. 2010

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In this study we developed a quantitative proteomic method named ICAT switch by introducing isotope-coded affinity tag (ICAT) reagents into the biotin-switch method, and used it to investigate S-nitrosation in the liver of normal control C57BL/6J mice and type 2 diabetic KK-Ay mice. We got fifty-eight S-nitrosated peptides with quantitative information in our research, among which thirty-seven had changed S-nitrosation levels in diabetic mouse liver. The S-nitrosated peptides belonged to fortyeight proteins (twenty-eight were new S-nitrosated proteins), some of which were new targets of S-nitrosation and known to be related with diabetes. S-nitrosation patterns were different between diabetic and normal mice. Gene ontology enrichment results suggested that S-nitrosated proteins are more abundant in amino acid metabolic processes. The network constructed for Snitrosated proteins by text-mining technology provided clues about the relationship between S-nitrosation and type 2 diabetes. Our work provides a new approach for quantifying S-nitrosated proteins and suggests that the integrative functions of S-nitrosation may take part in pathophysiological processes of type 2 diabetes.

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“…The main link between these diseases is increasing insulin levels as a result of insulin resistance (1). It has been shown that a diet with a higher ratio of glucose increases insulin resistance (2). For example, researchers reported that plasma levels of insulin and glucose showed a significant increase after receiving a diet with more sucrose (2).…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that a diet with a higher ratio of glucose increases insulin resistance (2). For example, researchers reported that plasma levels of insulin and glucose showed a significant increase after receiving a diet with more sucrose (2). Also, an increase in the proportion of sucrose in the diet was associated with an increase in the abdominal obesity index.…”

Section: Introductionmentioning

confidence: 99%

“…Also, an increase in the proportion of sucrose in the diet was associated with an increase in the abdominal obesity index. These are considered the parameters of classic insulin resistance (2). Exercise training plays a significant role as a major factor in the prevention, control and even improvement of insulin resistance and diabetes (3).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Resistance Training with Two Different Volumes on Serum Myonectin Levels in Rats Fed with Sucrose Solution

Adigozalpour

Safarzade

2017

Ann. Appl. Sport Sci

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Background. Moyenctin, is a new identified myokine and belongs to the CTRPs family which plays role in lipid and glucose metabolism. There is limited information available regarding the effects of exercise training on serum myonectin levels. Objectives. he aim of this study was to investigate the effects of sucrose solution intake and resistance training (RT) with two different volumes on serum myonectin levels and HOMA-IR in rats. Methods. Forty-eight male Wistar rats (10-12 weeks old) were randomly divided into six groups; Control (C), Low volume RT (L), High Volume RT (H), Sucrose Control (SC), Sucrose Low volume RT (SL) and Sucrose High volume RT (SH). The RT groups were subjected to a resistance training program with the use of a ladder (3 days/week, for 8 weeks). Body weight and serum levels of myonectin, insulin, glucose, and HOMA-IR were measured. Results. The results two way ANOVA showed that interaction between RT and sucrose solution significantly increased serum levels of insulin (P=0.007) and HOMAL-IR (P=0.002). Consumption of sucrose solution, significantly reduced serum myonectin (P=0.0001) and increased serum glucose, insulin and HOMA-IR (P=0.0001). Also RT significantly reduced serum myonectin, insulin and HOMA-IR (P=0.0001). No correlation was found between serum myonectin and insulin resistance in groups fed with normal foods (P=0.456), but in the groups fed with sucrose solution there was positive and significant correlation (P=0.0001). Conclusion. This data indicated that resistance training regardless of volume of training can reduce serum myonectin levels as well as insulin resistance in rats fed with sucrose solution or normal diet groups.

show abstract

Oxidative stress in mice is dependent on the free glucose content of the diet

Cited by 94 publications

References 43 publications

Acute Diphenyl Diselenide Treatment Reduces Hyperglycemia But Does Not Change Delta-Aminolevulinate Dehydratase Activity in Alloxan-Induced Diabetes in Rats

Acute Diphenyl Diselenide Treatment Reduces Hyperglycemia But Does Not Change Delta-Aminolevulinate Dehydratase Activity in Alloxan-Induced Diabetes in Rats

Quantitative proteomic analysis of S-nitrosated proteins in diabetic mouse liver with ICAT switch method

Effect of Resistance Training with Two Different Volumes on Serum Myonectin Levels in Rats Fed with Sucrose Solution

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