Oxidative stress in Mayaro virus infection

Camini, Fernanda Caetano; Caetano, Camila Carla da Silva; Almeida, Letícia Trindade; Guerra, Joyce Ferreira da Costa; Silva, Breno de Mello; Silva, Silvana de Queiroz; Magalhães, José Carlos de; Magalhães, Cíntia Lopes de Brito

doi:10.1016/j.virusres.2017.04.017

Cited by 38 publications

(33 citation statements)

References 48 publications

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“…Additionally, they observed an increase of reactive oxygen species (ROS) at early points of infection, which coincided with the acute phase of viral replication followed by TNF secretion 16 . These findings were confirmed by Camini et al 17 , who found that MAYV induces significant oxidative stress in infected HepG2 cells. An imbalance in the production of ROS and the cell’s inability to detoxify these reactive species may be responsible for this status 17 .…”

Section: Biology Of Mayaro Virussupporting

confidence: 70%

See 1 more Smart Citation

Mayaro: an emerging viral threat?

Acosta-Ampudia

Monsalve

Rodríguez

et al. 2018

Emerging Microbes & Infections

121

139

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Mayaro virus (MAYV), an enveloped RNA virus, belongs to the Togaviridae family and Alphavirus genus. This arthropod-borne virus (Arbovirus) is similar to Chikungunya (CHIKV), Dengue (DENV), and Zika virus (ZIKV). The term “ChikDenMaZika syndrome” has been coined for clinically suspected arboviruses, which have arisen as a consequence of the high viral burden, viral co-infection, and co-circulation in South America. In most cases, MAYV disease is nonspecific, mild, and self-limited. Fever, arthralgia, and maculopapular rash are among the most common symptoms described, being largely indistinguishable from those caused by other arboviruses. However, severe manifestations of the infection have been reported, such as chronic polyarthritis, neurological complications, hemorrhage, myocarditis, and even death. Currently, there are no specific commercial tools for the diagnosis of MAYV, and the use of serological methods can be affected by cross-reactivity and the window period. A diagnosis based on clinical and epidemiological data alone is still premature. Therefore, new entomological research is warranted, and new highly specific molecular diagnostic methods should be developed. This comprehensive review is intended to encourage public health authorities and scientific communities to actively work on diagnosing, preventing, and treating MAYV infection.

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Section: Biology Of Mayaro Virussupporting

confidence: 70%

“…These findings were confirmed by Camini et al 17 , who found that MAYV induces significant oxidative stress in infected HepG2 cells. An imbalance in the production of ROS and the cell’s inability to detoxify these reactive species may be responsible for this status 17 .…”

Section: Biology Of Mayaro Virussupporting

confidence: 70%

Mayaro: an emerging viral threat?

Acosta-Ampudia

Monsalve

Rodríguez

et al. 2018

Emerging Microbes & Infections

121

139

View full text Add to dashboard Cite

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“…This suggested that LGTV infection does not induce H 2 O 2 in BHK cells. On the other hand, it has been reported that a human liver-derived cell line infected with Togavirus, an arbovirus, were induced the production of ROS (Camini et al, 2017). Furthermore, Kuzmenko et al (2016) reported that ROS induction was observed when non-structural proteins of TBEV were expressed in a human kidney-derived cell line.…”

Section: Discussionmentioning

confidence: 99%

“…The Dengue virus, a known mosquito-borne flavivirus, requires the catalase gene to invade the mosquito midgut (Oliveira et al, 2017). Furthermore, some reports have demonstrated that mammalian cells which were infected with some arbovirus, such as Togaviridae, or expressing nonstructural proteins derived from TBEV were induced the production of ROS (Kuzmenko et al, 2016;Camini et al, 2017). These reports suggest that the H 2 O 2 -scavenging enzymes could also be important in the vector competency of arthropod-borne viruses.…”

Section: Introductionmentioning

confidence: 99%

A Peroxiredoxin From the Haemaphysalis longicornis Tick Affects Langat Virus Replication in a Hamster Cell Line

Kusakisako

Morokuma

Talactac

et al. 2020

Front. Cell. Infect. Microbiol.

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Ticks are hematophagous arthropods, and their blood feeding on vertebrate hosts is essential for their development. The vertebrate blood contains high levels of free iron that can react with oxygen in ticks, resulting in the production of hydrogen peroxide (H 2 O 2 ), one of the reactive oxygen species. Peroxiredoxins (Prxs), H 2 O 2 -scavenging enzymes, take on an important role in the ticks' oxidative stress coping mechanism. Ticks also transmit several disease-causing pathogens, including tick-borne encephalitis virus (TBEV), in animals and humans. Therefore, the control of ticks and tick-borne pathogens is a key issue that needs to be addressed. Infection with an arthropod-borne flavivirus is known to induce oxidative stress in insect cells. We hypothesize that vector-derived Prxs could have an effect on the infection and/or replication of flaviviruses in the hosts, since ticks Prxs are possibly transmitted from ticks to their hosts. In this study, we established stable strains of baby hamster kidney (BHK) cells expressing two types of H 2 O 2 -scavenging Prxs from the hard tick Haemaphysalis longicornis (BHK-HlPrx and BHK-HlPrx2 cells). Although the infection of TBEV surrogate Langat virus (LGTV) did not induce H 2 O 2 production in normal BHK cells, the mortality rate and the virus titer of LGTV infected BHK-HlPrx cells increased. In addition, HlPrx proteins in BHK cells can facilitate LGTV replication in cells, while HlPrx2 proteins in BHK cells cannot. The results also demonstrated that this facilitation of LGTV replication by the 1-Cys Prx in the BHK cells is not by scavenging H 2 O 2 but by an unknown mechanism. In order to understand this mechanism, more studies using tick-derived cells and ticks are necessary.

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“…Some of these cytokines have been shown to be associated with other pathologies involving bones and joints [47,52,53]. Mayaro fever can also induce oxidative stress (OS) in the liver of infected mice and in vitro infected HepG2 cells [54,55]. The induction of OS has also been observed in several other arbovirus infections, including Chikungunya [56][57][58].…”

Section: Clinical Manifestations and Pathogenesis Of Mayaro Fever In mentioning

confidence: 99%

Mayaro Virus Pathogenesis and Transmission Mechanisms

et al. 2020

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Mayaro virus (MAYV), isolated for the first time in Trinidad and Tobago, has captured the attention of public health authorities worldwide following recent outbreaks in the Americas. It has a propensity to be exported outside its original geographical range, because of the vast distribution of its vectors. Moreover, most of the world population is immunologically naïve with respect to infection with MAYV which makes this virus a true threat. The recent invasion of several countries by Aedesalbopictus underscores the risk of potential urban transmission of MAYV in both tropical and temperate regions. In humans, the clinical manifestations of MAYV disease range from mild fever, rash, and joint pain to arthralgia. In the absence of a licensed vaccine and clinically proven therapeutics against Mayaro fever, prevention focuses mainly on household mosquito control. However, as demonstrated for other arboviruses, mosquito control is rather inefficient for outbreak management and alternative approaches to contain the spread of MAYV are therefore necessary. Despite its strong epidemic potential, little is currently known about MAYV. This review addresses various aspects of MAYV, including its epidemiology, vector biology, mode of transmission, and clinical complications, as well as the latest developments in MAYV diagnosis.

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Oxidative stress in Mayaro virus infection

Cited by 38 publications

References 48 publications

Mayaro: an emerging viral threat?

Mayaro: an emerging viral threat?

A Peroxiredoxin From the Haemaphysalis longicornis Tick Affects Langat Virus Replication in a Hamster Cell Line

Mayaro Virus Pathogenesis and Transmission Mechanisms

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