Oxidative stress in juvenile common carp (Cyprinus carpio) exposed to TiO2 nanoparticles

Lee, Byoung Cheun; Kim, Young Ho; Cho, Jae-Gu; Lee, Jae Woo; Ryu, Tae Kwon; Yoon, Jun Heon; Lee, Sangeun; Duong, Cuong N.; Eom, Ig Chun; Kim, Pil Je; Choi, Kyung Hee

doi:10.1007/s13273-012-0044-2

Cited by 32 publications

(16 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antioxidant defense systems include a series of antioxidative enzymes and low-molecular non-enzymatic antioxidants, such as SOD activities, CAT activities and contents of MDA and GSH, which were all appropriate for monitoring oxidative stress status of fish after exposure to nano metal oxides (Hao et al 2009;Xiong et al 2011;Hao and Chen 2012;Lee et al 2012;Clemente et al 2013), in spite of the fact that some of the biomarker responses appear inconsistent because the mechanism is indirect as a consequence of the occlusion of tissue surfaces rather than more readily interpreted doseresponse relations. Indeed, the biomarker response varied in different organs and organs varied different sensitivity (detailed below), indicating possibly different toxicity mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the 96 h exposed zebrafish eggs to up to 500 mg/L of TiO 2 NPs did not cause alterations in the survival and hatching rates, or malformations (Zhu et al 2008). However, water column species are the primary concern in the risk assessment strategy for contaminants (Handy et al 2012) and then sublethal effects have been observed, mainly related to oxidative stress and inflammation (Federici et al 2007;Hao et al 2009;Palaniappan and Pramod 2010;Xiong et al 2011;Lee et al 2012). It is likely that a subacute or chronic exposure may more acutely reveal the toxicity of TiO 2 NPs and be of more ecological importance in environmental risk evaluation.…”

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

Effects of humic acid and ionic strength on TiO2 nanoparticles sublethal toxicity to zebrafish

Fang

Zhang

et al. 2015

Ecotoxicology

View full text Add to dashboard Cite

The stability and bioavailability of titanium dioxide nanoparticles (TiO 2 NPs) suspension could be modified by the physicochemical properties of solution. In the present study, the effect of humic acid (HA) and ionic strength (by adding NaCl) on aggregation and sedimentation of TiO 2 NPs suspension were investigated. Accordingly, the sublethal toxicity of TiO 2 NPs suspensions with different HA and NaCl concentrations toward zebrafish (Danio rerio) was evaluated by monitoring the changes of superoxide dismutase, catalase, malonaldehyde and glutathione in gill, liver and intestine. The results showed that the aggregations formation and hydrodynamic diameter of TiO 2 NPs in suspensions are not essential characteristics to decide toxicity. The varied oxidative stress responses detected in gill, liver and intestine derived from different toxicity mechanisms of TiO 2 NPs. Nevertheless, the oxidative stress could be suppressed by the adding of HA and/or the increase of ionic strength, which can decrease the bioavailability of TiO 2 NPs in water. The study suggests that the environmental factors, such as HA and ionic strength, are important for the fate (aggregation and sedimentation) and toxicity of nanomaterials in aquatic environment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Effects of humic acid and ionic strength on TiO2 nanoparticles sublethal toxicity to zebrafish

Fang

Zhang

et al. 2015

Ecotoxicology

View full text Add to dashboard Cite

show abstract

“…Apart from their useful benefits of these nanoparticles, application in diverse fields has raised a major concern for the environment (Iavicoli et al 2012). The titanium oxide nanoparticles from different sources reach the aquatic environment as an ultimate sink for these contaminants, and the inhabiting organisms will suffer from an accumulation of these nanoparticles (Lee et al 2012). The photo activation of titanium oxide nanoparticles leads to the formation of highly oxidising reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Assessment of cytotoxicity and oxidative stress induced by titanium oxide nanoparticles on Chinook salmon cells

Srikanth

Pereira

Duarte

et al. 2015

Environ Sci Pollut Res

View full text Add to dashboard Cite

Titanium oxide nanoparticles (TiO2 NPs) have received wide attention in diverse application, but the potential impact of these nanomaterials on the environment, aquatic life and especially on fish cell lines is lacking. The present study aimed to investigate the cytotoxicity and oxidative stress induced by TiO2 NPs on Chinook salmon cells derived from Oncorhynchus tshawytscha embryos (CHSE-214). The The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide] and neutral red (NR) assays in CHSE-214 cells exposed to TiO2 NPs revealed concentration-dependent cytotoxic effect in the range of 10 to 60 μg/ml for 24 h. CHSE-214 cells exposed to TiO2 NPs (10-60 μg/ml) exhibited significant decline in superoxide dismutase (SOD), catalase (CAT) glutathione (GSH) content and increased lipid peroxidation (LPO) in a concentration-dependent manner. TiO2 NPs induced cytotoxicity and oxidative stress in CHSE-214 cells which serve as a base line studies for future studies.

show abstract

“…[16][17][18] In all cases, the cytotoxic mechanism was suggested to involve pathways for oxidative stress and induction of apoptosis in the mitochondria. [19][20][21][22][23][24] On the other hand, administration of SiO 2 nanoparticles in rats did not have any toxic effect, except for formation of granuloma in the liver and spleen. 25 In the in vivo setting, when reconstituted nanoparticles in solution are administered via intravenous or intracerebral injection, nanoparticles would encounter proteins from blood or cerebrospinal fluid, which would influence their interactions at the cellular and tissue levels.…”

Section: Introductionmentioning

confidence: 91%

Analysis of SiO2 nanoparticles binding proteins in rat blood and brain homogenate

Shim¹,

Hulme²,

Maeng³

et al. 2014

IJN

View full text Add to dashboard Cite

A multitude of nanoparticles, such as titanium oxide (TiO 2 ), zinc oxide, aluminum oxide, gold oxide, silver oxide, iron oxide, and silica oxide, are found in many chemical, cosmetic, pharmaceutical, and electronic products. Recently, SiO 2 nanoparticles were shown to have an inert toxicity profile and no association with an irreversible toxicological change in animal models. Hence, exposure to SiO 2 nanoparticles is on the increase. SiO 2 nanoparticles are routinely used in numerous materials, from strengthening filler for concrete and other construction composites, to nontoxic platforms for biomedical application, such as drug delivery and theragnostics. On the other hand, recent in vitro experiments indicated that SiO 2 nanoparticles were cytotoxic. Therefore, we investigated these nanoparticles to identify potentially toxic pathways by analyzing the adsorbed protein corona on the surface of SiO 2 nanoparticles in the blood and brain of the rat. Four types of SiO 2 nanoparticles were chosen for investigation, and the protein corona of each type was analyzed using liquid chromatography-tandem mass spectrometry technology. In total, 115 and 48 plasma proteins from the rat were identified as being bound to negatively charged 20 nm and 100 nm SiO 2 nanoparticles, respectively, and 50 and 36 proteins were found for 20 nm and 100 nm arginine-coated SiO 2 nanoparticles, respectively. Higher numbers of proteins were adsorbed onto the 20 nm sized SiO 2 nanoparticles than onto the 100 nm sized nanoparticles regardless of charge. When proteins were compared between the two charges, higher numbers of proteins were found for arginine-coated positively charged SiO 2 nanoparticles than for the negatively charged nanoparticles. The proteins identified as bound in the corona from SiO 2 nanoparticles were further analyzed with ClueGO, a Cytoscape plugin used in protein ontology and for identifying biological interaction pathways. Proteins bound on the surface of nanoparticles may affect functional and conformational properties and distributions in complicated biological processes.

show abstract

Oxidative stress in juvenile common carp (Cyprinus carpio) exposed to TiO2 nanoparticles

Cited by 32 publications

References 31 publications

Effects of humic acid and ionic strength on TiO2 nanoparticles sublethal toxicity to zebrafish

Effects of humic acid and ionic strength on TiO2 nanoparticles sublethal toxicity to zebrafish

Assessment of cytotoxicity and oxidative stress induced by titanium oxide nanoparticles on Chinook salmon cells

Analysis of SiO2 nanoparticles binding proteins in rat blood and brain homogenate

Contact Info

Product

Resources

About