Oxidative stress in infants born to preeclamptic mothers

Tastekin, Ayhan; Örs, Rahmi; Demircan, Berna; Saricam, Zeki; İngeç, Metin; Akçay, Fatih

doi:10.1111/j.1442-200x.2005.02146.x

Cited by 35 publications

(25 citation statements)

References 39 publications

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“…It has been suggested that there is a deficiency in the protective antioxidant systems or increased utilisation of antioxidants in pre-eclampsia compared with normal pregnancy. 8 Contrary to many other studies 9,23 suggesting a role of oxidative stress in pre-eclampsia, some reports 8,24,25 documented that there were no significant differences between the oxidant or antioxidant activity or both in pre-eclampsia and in normal pregnancy. We found significant increase in MDA levels, an indicator of lipid peroxidation, in pre-eclampsia and eclampsia as compared to healthy pregnancy.…”

Section: Discussionmentioning

confidence: 83%

“…7 An increase in lipid peroxidation products and/or a decrease in antioxidant activity in pre-eclampsia have been described in various reports. [7][8][9][10] Neutrophils are considered to be major effector cells in the tissue damage that occurs in inflammatory disease. 11 Although the specific mechanism of neutrophil activation in pre-eclampsia remains unknown, it is possible that placental hypoxia leads to production of pro-inflammatory cytokines and subsequent neutrophil activation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum advanced oxidation protein products, myeloperoxidase and ascorbic acid in pre‐eclampsia and eclampsia

Noyan¹,

Güler²,

Şekeroğlu³

et al. 2006

Aust NZ J Obst Gynaeco

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Serum advanced oxidation protein products, myeloperoxidase and ascorbic acid in pre‐eclampsia and eclampsia

Noyan¹,

Güler²,

Şekeroğlu³

et al. 2006

Aust NZ J Obst Gynaeco

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“…10,12 However, the previous studies have focused on maternal parameters, and only a single study appears to have been carried out in the fetus. 23 We shoed that umbilical venous concentrations of TBARS were also significantly increased after preeclamptic pregnancy, indicative of increased oxidative stress. Defective placentation in preeclampsia could prevent the active placental transport of these lipid peroxides away from the fetus, thus increasing the levels of TBARS in the umbilical venous samples.…”

Section: Discussionmentioning

confidence: 87%

Reduced Selenium Concentrations and Glutathione Peroxidase Activity in Preeclamptic Pregnancies

et al. 2008

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Abstract-Preeclampsia is pregnancy-specific, affecting 2% to 7% of women, and is a leading cause of perinatal and maternal morbidity and mortality. Preeclampsia may also predispose the fetus to increased risks of adult cardiovascular disease. Selenium, acting through the selenoprotein glutathione peroxidases, has critical roles in regulating antioxidant status. Recent reports implicate poor maternal selenium status as a nutritional factor predisposing the mother to preeclampsia but the fetus and placenta have not been studied in tandem. Measurement of selenium concentrations, expression, and activity levels of glutathione peroxidase and markers of oxidative stress were performed on maternal and umbilical venous blood samples or the placenta from 27 normal pregnant, 25 preeclamptic, and 22 healthy age-matched nonpregnant women. The results of this study revealed highly significant reductions in serum selenium concentrations and plasma glutathione peroxidase activity in pregnancy per se compared to nonpregnant controls. Moreover, these levels were further decreased in the preeclamptic mothers and babies compared to normal pregnancies. Umbilical venous selenium was particularly low (42.1Ϯ11.8 and 29.0Ϯ9.9 g/L; meanϮSD; PϽ0.05). Both mother and baby had significantly increased levels of markers for oxidative stress in the preeclamptic group. The placental glutathione peroxidase activity and immunohistochemical staining were also reduced in the preeclampsia placentae.Oxidative stress associated with preeclampsia may be a consequence of reduced antioxidant defense pathways specifically involving glutathione peroxidases, perhaps linked to reduced selenium availability. Reduced glutathione peroxidases could be associated with increased generation of toxic lipid peroxides contributing to the endothelial dysfunction and hypertension of preeclampsia. Key Words: pregnancy Ⅲ human Ⅲ preeclampsia Ⅲ hypertension Ⅲ oxidative stress Ⅲ selenium Ⅲ glutathione peroxidase Ⅲ placenta P reeclampsia is estimated to occur in 2% to 7% of all pregnancies and is a leading cause of maternal and perinatal mortality and morbidity in the Western world. 1,2 The effects of the disease are not restricted to pregnancy, as it also predisposes both the mother and baby to adult cardiovascular disease. 3 Preeclampsia is now commonly regarded as being a state of oxidative stress (see: 4 ). It is thought that excessive production of reactive oxygen species (ROS), secondary to reduced placental perfusion, results in oxidative stress, playing a critical role as a possible mediator of endothelial cell dysfunction, 5 hypertension, and thus clinical manifestations of preeclampsia. 6 The trace element selenium is an essential component of the antioxidant selenoproteins, including glutathione peroxidases (GPx). These remove the products of attack by hydroperoxides and oxidized lipoproteins, 7 and so limit adverse effects on the endothelium. 8 Various forms of GPx are found in vertebrates: the cellular and cytosolic GPx (GPx1), the cytosolic gastrointestinal GP...

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“…Furthermore, polyunsaturated diacyl-PCs can promote the oxidation and fragmentation of γ-hydroxyalkenals [29]. Oxidative stress (OS) can occur early in pregnancy [30], induce pregnancy-related disorders like preeclampsia [31][32][33] and preterm premature rupture of membranes [34][35][36], and is considered a detrimental factor in preterm birth pathology [25]. Results of the current study showed that unsaturated diacyl-PCs (PCaaC36:4, PCaaC38:4, PCaaC38:5, PCaaC38:6, PCaaC40:4, PCaaC40:5, PCaaC40:6, PCaaC42:4), especially PCaaC38:6, were negatively correlated with gestational age.…”

Section: Discussionmentioning

confidence: 99%

Maternal PCaaC38:6 is Associated With Preterm Birth - a Risk Factor for Early and Late Adverse Outcome of the Offspring

Reichetzeder

et al. 2016

Kidney Blood Press Res

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Background/Aims: Preterm birth (PTB) and low birth weight (LBW) significantly influence mortality and morbidity of the offspring in early life and also have long-term consequences in later life. A better understanding of the molecular mechanisms of preterm birth could provide new insights regarding putative preventive strategies. Metabolomics provides a powerful analytic tool to readout complex interactions between genetics, environment and health and may serve to identify relevant biomarkers. In this study, the association between 163 targeted maternal blood metabolites and gestational age was investigated in order to find candidate biomarkers for PTB. Methods: Five hundred twenty-three women were included into this observational study. Maternal blood was obtained before delivery. The concentration of 163 maternal serum metabolites was measured by flow injection tandem mass spectrometry. To find putative biomarkers for preterm birth, a three-step analysis was designed: bivariate correlation analysis followed by multivariable regression analysis and a comparison of mean values among gestational age groups. Results: Bivariate correlation analysis showed that 2 acylcarnitines (C16:2, C2), 1 amino acids (xLeu), 8 diacyl-PCs (PCaaC36:4, PCaaC38:4, PCaaC38:5, PCaaC38:6, PCaaC40:4, PCaaC40:5, PCaaC40:6, PCaaC42:4), and 1 Acylalkyl-PCs (PCaeC40:5) were inversely correlated with gestational age. Multivariable regression analysis confounded for PTB history, maternal body mass index (BMI) before pregnancy, systolic blood pressure at the third trimester, and maternal body weight at the third trimester, showed that the diacyl-PC PCaaC38:6 was the only metabolite inversely correlated with gestational age. Conclusions: Maternal blood concentrations of PCaaC38:6 are independently associated with gestational age.

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Oxidative stress in infants born to preeclamptic mothers

Abstract: We concluded that although cord plasma MDA levels were similar in both the preeclamptic and control groups, increased SOD activity might be an indicator of increased oxidative stress in infants born to preeclamptic mothers.

Cited by 35 publications

References 39 publications

Serum advanced oxidation protein products, myeloperoxidase and ascorbic acid in pre‐eclampsia and eclampsia

Serum advanced oxidation protein products, myeloperoxidase and ascorbic acid in pre‐eclampsia and eclampsia

Reduced Selenium Concentrations and Glutathione Peroxidase Activity in Preeclamptic Pregnancies

Maternal PCaaC38:6 is Associated With Preterm Birth - a Risk Factor for Early and Late Adverse Outcome of the Offspring

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