Oxidative Stress in Human Health and Disease

Quaye, Isaac

doi:10.5772/34044

Cited by 1 publication

(1 citation statement)

References 213 publications

(233 reference statements)

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“…•-), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH • ); unlike oxygen, they are reactive, whereby in normal conditions and at physiological concentrations participate in the processes of growth, differentiation, development and cell death, as well as in several other processes of bioregulation as natural molecules, signaling, intracellular messengers and potential factors of intercellular communication [9]. Normally, excess of ROS is scavenged by antioxidant defense system in the mitochondria.…”

Section: Introductionmentioning

confidence: 99%

Interplay between antioxidant activity, health and disease

2019

Biointerface Res Appl Chem

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The article discusses the relationship between oxidative stress (OS) and pathological conditions, the possibilities and benefits of estimating OS considering the integral antioxidant activity (AOA) as an OS criterion, and using a simple accessible hybrid potentiometric method (HPM) with a mediator system for AOA monitoring. The results of AOA of blood serum in healthy volunteers and patients with various diseases are presented. Preliminary reference values are found. The lower levels of AOA of blood serum in patients with different diseases in comparison with the control group are observed. The potential mechanisms of changes in the AOA levels and it’s clinical significance are discussed from the position of biointerfaces interplay. With AOA equal or greater than 1.40 mmol-eq l–1 the person is healthy, the range from 0.95 to 1.40 mmol-eq l–1 indicates that the patient is at risk and needs to undergo a further medical examination. When AOA blood serum is below 0.95 mmol-eq l–1, detailed diagnostics and relevant treatment are required. The findings allow suggesting that the approach determine antioxidant/oxidant activity of biological fluids holds considerable promise for monitoring OS; it opens up new opportunities in expanding the use of analytical chemistry in medicine.

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Section: Introductionmentioning

confidence: 99%

Interplay between antioxidant activity, health and disease

2019

Biointerface Res Appl Chem

View full text Add to dashboard Cite

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Oxidative Stress in Human Health and Disease

Cited by 1 publication

References 213 publications

Interplay between antioxidant activity, health and disease

Interplay between antioxidant activity, health and disease

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