“…Joenje et al later reported that chromosomal aberrations in FA were oxygen dependent (52). Since then, oxidative stress was found to modulate cell growth (26,90,91) and cycle in FA cells (26,(90)(91)(92)105) and linked to FA-associated chromosomal instability (26,52,68,90,91,100). Both in vitro and in vivo evidence indicated that FA cells were in a prooxidant state (1, 8, 11, 17, 18, 20-22, 26, 28, 37, 68, 69, 71-77, 87, 88, 90-92, 100, 103, 134).…”