Oxidative stress in erythrocytes from patients with rheumatoid arthritis

Staroń, Agnieszka; Mąkosa, Grzegorz; Koter−Michalak, Maria

doi:10.1007/s00296-010-1611-2

Cited by 51 publications

(43 citation statements)

References 21 publications

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“…Level of the lipid peroxidation is significantly higher in the patients with RA than in the control group and it is in agreement with most studies Sarban et al [29]. On the basis of the obtained results and the literature data, it can be concluded that in RA, red blood cells are more susceptible to the influence of free radicals Staroń et al [30].…”

Section: Discussionsupporting

confidence: 90%

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Immunosuppressive Effects of Mesenchymal Stem Cells versus Corticosteroid in Experimental Model of Arthritis

ESM¹

2012

Clinic Experiment Pharmacol

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Objective: The objective of this study was to compare between the efficacies of mesenchymal stem cell (MSC) and betamethasone in the treatment of rheumatoid arthritis.Material and method: 90 male albino mice were divided equally into 2 models as follows: MSC model, group 1: saline control group, group 2: Acetic acid, group 3: CIA, group 4: induced arthritis mice that received intravenous injection of MSCs. Betamethasone model, group 1: phosphate buffer saline, group 2: Acetic acid, group 3: betamethasone control, group 4: CIA, group 5: induced arthritis mice that received intraperitoneal injection of betamethasone. Mice arthritis models were assessed by clinical paw edema and x-rays, at the proper time of sacrefaction, tissues were collected and examined using real-time PCR (RT-PCR), synovial tissue was examined for (IL-10) interleukin-10 (TNF-α), tumor necrosis factor-α, (COMP)-Cartilage oligomeric matrix protein, (MMP-3) Matrix metalloproteinase3. While (MDA), (LDH), (GSH), (CAT) and (MPO) were determined using colorimetric kits. In addition detection of serum level of (IgG), (RF), (CRP), (ANA) by enzyme-linked immunosorbent assay (ELISA).Also detection of blood (ESR).Results: Histopathological, paw edema and PCR results showed improvement of the group that received MSC compared to the diseased group and group received betamethasone. Conclusion:MSC significantly enhance the efficacy of collagen-induced arthritis treatment, which is superior to betamethasone treatment likely through the modulation of the expression of various cytokines.

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Section: Discussionsupporting

confidence: 90%

“…His results confirm increase in oxidative stress in RA patients, while, Staroń et al [30] stated that there is no significant difference between CAT and GSH activities as regarding RA. In Sarban et al [29] study, the concentration of the GSH is about 20% lower in RA patients than in healthy subjects.…”

Section: Discussionmentioning

confidence: 82%

Immunosuppressive Effects of Mesenchymal Stem Cells versus Corticosteroid in Experimental Model of Arthritis

ESM¹

2012

Clinic Experiment Pharmacol

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“…It is well known that the serum SH groups levels are modified in many diseases, including obesity, indicating that SH groups content is a useful biochemical marker of "in vivo" oxido-reduction reactions (16). Membrane SH groups are liable to be modified by different oxidants or alkylating agents, increasing their membrane permeability to different ions, such as Ca ++ , which can promote excitotoxicity, by RNS and ROS that lead to lipid peroxidation, increasing the levels of TBARS and decreased concentration of SH groups in membrane proteins (17). Thiol-containing molecules with SH bonds such as glutathione (GSH) suppress oxidative damage and involve the maintenance of the cell redox status.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of salivary oxidative parameters in overweight and obese young adults

Chielle

Casarin

2017

Arch. Endocrinol. Metab.

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Background: Obesity is characterized by a deposition of abnormal or excessive fat in adipose tissue, and is linked with a risk of damage to several metabolic and pathological processes associated with oxidative stress. To date, salivary oxidative biomarkers have been minimally explored in obese individuals. Thus, the aim of this study was to assess the concentrations of salivary oxidative biomarkers (ferric-reducing antioxidant power, uric acid, sulfhydryl groups) and lipid peroxidation in obese and overweight young subjects. Materials and methods: Levels of lipid peroxidation, ferricreducing antioxidant power, uric acid, and SH groups were determined in the saliva and serum of 149 young adults, including 54 normal weight, 27 overweight, and 68 obese individuals. Anthropometric measurements were also evaluated. Results: Salivary levels of ferric-reducing antioxidant power, sulfhydryl groups, and lipid peroxidation, as well as serum levels of ferric-reducing antioxidant power, uric acid, and lipid peroxidation were higher in obese patients when compared with individuals with normal weight. There were correlations between salivary and serum ferric-reducing antioxidant power and salivary and serum uric acid in the obese and normal-weight groups. Conclusions: Our results indicate that the increase in salivary levels of ferric-reducing antioxidant power, sulfhydryl groups, and lipid peroxidation, and serum levels of ferric-reducing antioxidant power, uric acid, and lipid peroxidation could be related to the regulation of various processes in the adipose tissue. These findings may hold promise in identifying new oxidative markers to assist in diagnosing and monitoring overweight and obese patients. Arch Endocrinol Metab. 2017;61(2):152-9.

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“…We read with great interest the article by Staron et al [1] dealing with an association between oxidative stress parameters in erythrocytes and rheumatoid arthritis (RA) patients. The authors have analyzed thiobarbituric acid, total ATPase, Na ?…”

Section: Sirmentioning

confidence: 99%

Comment on: Oxidative stress in erythrocytes from patients with rheumatoid arthritis

et al. 2012

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Oxidative stress in erythrocytes from patients with rheumatoid arthritis

Cited by 51 publications

References 21 publications

Immunosuppressive Effects of Mesenchymal Stem Cells versus Corticosteroid in Experimental Model of Arthritis

Immunosuppressive Effects of Mesenchymal Stem Cells versus Corticosteroid in Experimental Model of Arthritis

Evaluation of salivary oxidative parameters in overweight and obese young adults

Comment on: Oxidative stress in erythrocytes from patients with rheumatoid arthritis

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