Oxidative stress in epilepsy with comorbid psychiatric illness

Pandey, Manmohan Krishna; Mittra, Purnima; Maheshwari, Piyush

doi:10.5455/njppp.2013.3.92-96

Cited by 4 publications

(6 citation statements)

References 11 publications

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“…The majority of studies confirmed impaired oxidative status in untreated patients with epilepsy in terms of elevated lipid peroxidation reflected in elevated MDA levels [ 1 , 33 , 37 , 42 , 44 , 46 , 47 ] and significantly decreased serum total antioxidant capacity [ 7 , 32 , 44 ]. Studies further reported elevated [ 32 , 35 ], decreased [ 43 , 46 ] or unchanged [ 31 , 37 ] SOD activity, elevated [ 31 ], unchanged [ 32 , 37 , 44 ] or decreased [ 36 ] GPx activity, unchanged [ 31 ] or decreased [ 37 ] GR activity and unchanged CAT activity [ 43 ].…”

Section: Oxidative Stress In Drug-naive Patients With Epilepsymentioning

confidence: 99%

“…A selection criterion for inclusion of the study was the comparison of untreated patients with confirmed epilepsy with a control group, presented by healthy control matches. Eleven studies were found which met the inclusion criteria [ 1 , 31 - 33 , 37 , 42 - 47 ].…”

Section: Oxidative Stress In Drug-naive Patients With Epilepsymentioning

confidence: 99%

“…In the case of CBZ influence on lipid peroxidation inconsistent results were found. Some studies have shown increased oxidative stress expressed as lipid peroxidation [ 7 , 33 , 44 , 53 ], some have shown ambiguous changes [ 1 , 6 ] and the others decreased [ 31 , 42 ] lipid peroxidation compared to untreated patients with epilepsy [ 1 , 6 , 31 , 33 , 42 , 44 ] or healthy controls [ 7 , 53 ]. Hammed et al .…”

Section: Oxidative Stress In Patients With Epilepsy Treated With the mentioning

confidence: 99%

“…A selection criterion for inclusion of the study was the presence of a group of patients with epilepsy on therapy with VPA or CBZ and a control group of untreated patients with epilepsy. Seven [ 1 , 31 - 33 , 43 - 45 ] and six [ 1 , 6 , 31 , 33 , 42 , 44 ] studies were found which met the inclusion criteria for VPA and CBZ, respectively. WMD with 95% confidence interval (95% CI) were calculated from the extracted data.…”

Section: Oxidative Stress In Patients With Epilepsy Treated With the mentioning

confidence: 99%

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Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

Martinc¹,

Grabnar²,

Vovk

2015

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Epilepsy is known as one of the most frequent neurological diseases, characterized by an enduring predisposition to generate epileptic seizures. Oxidative stress is believed to directly participate in pathways leading to neurodegeneration, which serves as the most important propagating factor, leading to the epileptic condition and cognitive decline. Moreover, there is also a growing body of evidence showing the disturbance of antioxidant system balance and consequently increased production of reactive species in patients with epilepsy. A meta-analysis, conducted in the present review confirms an association between epilepsy and increased lipid peroxidation. Furthermore, it was also shown that some of the antiepileptic drugs could potentially be responsible for additionally increased lipid peroxidation. Therefore, it is reasonable to propose that during the epileptic process neuroprotective treatment with antioxidants could lead to less sever structural damages, reduced epileptogenesis and milder cognitive deterioration. To evaluate this hypothesis studies investigating the neuroprotective therapeutic potential of various antioxidants in cells, animal seizure models and patients with epilepsy have been reviewed. Numerous beneficial effects of antioxidants on oxidative stress markers and in some cases also neuroprotective effects were observed in animal seizure models. However, despite these encouraging results, till now only a few antioxidants have been further applied to patients with epilepsy as an add-on therapy. Based on the several positive findings in animal models, a strong need for more carefully planned, randomized, double-blind, cross-over, placebo-controlled clinical trials for the evaluation of antioxidants efficacy in patients with epilepsy is warranted.

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Section: Oxidative Stress In Drug-naive Patients With Epilepsymentioning

confidence: 99%

Section: Oxidative Stress In Drug-naive Patients With Epilepsymentioning

confidence: 99%

Section: Oxidative Stress In Patients With Epilepsy Treated With the mentioning

confidence: 99%

Section: Oxidative Stress In Patients With Epilepsy Treated With the mentioning

confidence: 99%

See 2 more Smart Citations

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

Martinc¹,

Grabnar²,

Vovk

2015

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“…Данную активацию наблюдали в первые часы после пароксизма, она была наиболее выраженной в случае эпилептического приступа. В исследовании M. Pandey [33] было изучено содержание малонового диальдегида, одного из конечных продуктов ПОЛ у 210 больных эпилепсией, имевших ассоциированные с этим заболеванием психические расстройствапсихозы и депрессию. Уровень МДА был значительно выше у этих больных по сравнению с контрольной группой.…”

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Oxidative stress in epilepsy

Федин

Starykh

Torshin

2019

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Свободнорадикальное окисление является универсальным патофизиологическим феноменом при многих патологических состояниях. Кислород для любой клетки, особенно для нейрона, является ведущим энергоакцептором в дыхательной митохондриальной цепи. Связываясь с атомом железа цитохромоксидазы, молекула кислорода подвергается электронному восстановлению, участвуя в образовании молекулы воды. Но в условиях нарушения энергообразующих процессов при неполном восстановлении кислорода происходит образование высокореактивных, а потому токсичных, свободных радикалов или продуктов, их генерирующих. В последние годы окислительный стресс рассматривается также как один из наиболее значимых факторов патогенеза сосудистых заболеваний мозга, нейродегенеративных заболеваний, таких как болезнь Альцгеймера и деменции других типов, болезнь Паркинсона, боковой амиотрофический склероз, эпилепсия и рассеянный склероз [1]. В ряде публикаций окислительный стресс рассматривается в качестве возможного механизма в патогенезе эпи

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Review article. Predicting disease onset in clinically healthy people

Zeliger

2016

Interdisciplinary Toxicology

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Virtually all human disease is induced by oxidative stress. Oxidative stress, which is caused by toxic environmental exposure, the presence of disease, lifestyle choices, stress, chronic inflammation or combinations of these, is responsible for most disease. Oxidative stress from all sources is additive and it is the total oxidative stress from all sources that induces the onset of most disease. Oxidative stress leads to lipid peroxidation, which in turn produces Malondialdehyde. Serum malondialdehyde level is an additive parameter resulting from all sources of oxidative stress and, therefore, is a reliable indicator of total oxidative stress which can be used to predict the onset of disease in clinically asymptomatic individuals and to suggest the need for treatment that can prevent much human disease.

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Oxidative stress in epilepsy with comorbid psychiatric illness

Cited by 4 publications

References 11 publications

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

Oxidative stress in epilepsy

Review article. Predicting disease onset in clinically healthy people

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