Oxidative Stress in Entamoeba histolytica

Dam, Somasri; Biswas, Pinaki; Ghosh, Raktim

doi:10.1007/978-981-13-8763-0_14

Cited by 4 publications

(1 citation statement)

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“…Absence of catalase, glutathione reductase, and glutathione peroxidise, all of which are present in other aerotolerant protozoans shows that E. histolytica is very unique and has developed some alternative defence strategies ( Mehlotra, 1996 ). The major thiol present in the parasite is L-cysteine which is of low molecular weight as compared to glutathione and is required for growth, virulence and antioxidant defence ( Dam et al., 2019 ). L-cysteine, being the most important antioxidant in E. histolytica , can be synthesised or acquired by the parasite from the external medium.…”

Section: Cellular Drug Targetsmentioning

confidence: 99%

Revisiting Drug Development Against the Neglected Tropical Disease, Amebiasis

Shrivastav

Malik

Somlata

2021

Front. Cell. Infect. Microbiol.

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Amebiasis is a neglected tropical disease which is caused by the protozoan parasite Entamoeba histolytica. This disease is one of the leading causes of diarrhea globally, affecting largely impoverished residents in developing countries. Amebiasis also remains one of the top causes of gastrointestinal diseases in returning international travellers. Despite having many side effects, metronidazole remains the drug of choice as an amebicidal tissue-active agent. However, emergence of metronidazole resistance in pathogens having similar anaerobic metabolism and also in laboratory strains of E. histolytica has necessitated the identification and development of new drug targets and therapeutic strategies against the parasite. Recent research in the field of amebiasis has led to a better understanding of the parasite’s metabolic and cellular pathways and hence has been useful in identifying new drug targets. On the other hand, new molecules effective against amebiasis have been mined by modifying available compounds, thereby increasing their potency and efficacy and also by repurposing existing approved drugs. This review aims at compiling and examining up to date information on promising drug targets and drug molecules for the treatment of amebiasis.

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Section: Cellular Drug Targetsmentioning

confidence: 99%