Oxidative stress in drug naïve first episode psychosis and antioxidant effects of risperidone

Noto, Cristiano; Ota, Vanessa Kiyomi; Gadelha, Ary; Noto, Mariane Nunes; Barbosa, Décio Sabbatini; Bonifácio, Kamila Landucci; Nunes, Sandra Odebrecht Vargas; Cordeiro, Quirino; Belangero, Síntia Iole; Bressan, Rodrigo A.; Maes, Michaël; Brietzke, Elisa

doi:10.1016/j.jpsychires.2015.07.003

Cited by 61 publications

(64 citation statements)

References 55 publications

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“…Impaired antioxidant defence and increased levels of the lipid peroxidation product-malondialdehyde-were also detected in the serum of chronic SCZ patients [58,59]. It was shown that increasing lipid peroxidation accompanies SCZ [65] and further suggested that lowered PON1 activity in the early phase of illness might be associated with increased lipid peroxidation during the course of SCZ [48]. Moreover, the decreased PON1 activity levels in drug-naïve FEP patients was indicated as a key component of the disease rather than a consequence of antipsychotic treatment [62].…”

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

“…Converging evidence indicates that the OS plays a role in SCZ pathophysiology [46][47][48][49]. A study on the disturbances in antioxidative defense systems indicated an increase in free radical generation and antioxidant defense impairment in SCZ patients [46].…”

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

“…In drug-naïve FEP patients, paraoxonase 1 (PON1)-an antioxidant and anti-inflammatory enzyme that protects high-density lipoprotein particles against OS damage [62,63]-was decreased when compared to healthy controls [48,62]. Decreased levels of PON1 activity in FEP indicate lowered protection against lipid peroxidation and lowered anti-inflammatory potential [64].…”

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

“…Increased total radical-trapping antioxidant parameter (TRAP)-a marker of total non-enzymatic antioxidant defenses [66]-was also detected in drug-naïve FEP patients [48]. Increased TRAP can possibly be an early compensatory mechanism, which may counterbalance the increase in ROS production [48].…”

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

“…Increased TRAP can possibly be an early compensatory mechanism, which may counterbalance the increase in ROS production [48]. Hence, it was suggested that in an early phase, SCZ may be characterised by lowered PON1 activity and compensatory elevations in non-enzymatic antioxidants [48].…”

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

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Biomarkers and schizophrenia: a qualitative review

Silva¹,

Pinto²

2017

IJCNMH

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Schizophrenia (SCZ) is a psychiatric disorder with a broad spectrum of biological and clinical manifestations of yet not completely clear pathophysiological mechanisms. Several lines of evidence have been supporting the idea that immunoinflammatory, oxidative, hormonal and cellular dysfunctions are implicated on the biomolecular basis of SCZ. However, accurate diagnosis and selection of appropriate treatments remains challenging as a result of the scarcity of objective tests. Furthermore, there is a compelling need to find biomarkers that could predict drug response and tailor pharmacological treatment, particularly in drug-naïve first episode psychosis (FEP). Hence, numerous technologies have been employed in order to search for SCZ biological markers, but evidence relating them to treatment efficacy is lacking. In this regard, some preliminary data suggest promising results. The current review provides information on: (1) potential biomarkers associated with biological disturbances and (2) biological markers associated with treatment response.

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Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

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Biomarkers and schizophrenia: a qualitative review

Silva¹,

Pinto²

2017

IJCNMH

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The Effects of Prenatal Iron Deficiency and Risperidone Treatment on the Rat Frontal Cortex: A Proteomic Analysis

et al. 2017

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Prenatal iron deficiency (pID) has been described to increase the risk for neurodevelopmental disorders such as autism and schizophrenia; however, the precise molecular mechanisms are still unknown. Here, we utilized high-throughput MS to examine the proteomic effects of pID in adulthood on the rat frontal cortex area (FCA). In addition, the FCA proteome was examined in adulthood following risperidone treatment in adolescence to see if these effects could be prevented. We identified 1501 proteins of which 100 were significantly differentially expressed in the FCA at postnatal day 90. Pathway analysis of proteins affected by pID revealed changes in metabolic processes, including the tricyclic acid cycle, mitochondrial dysfunction, and P13K/Akt signaling. Interestingly, most of these protein changes were not present in the adult pID offspring who received risperidone in adolescence. Considering the link between pID and several neurodevelopmental disorders such as autism and schizophrenia these presented results bring new perspectives to understand the role of iron in metabolic pathways and provide novel biomarkers for future studies of pID.

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Supervised machine learning to decipher the complex associations between neuro-immune biomarkers and quality of life in schizophrenia

2018

Self Cite

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Stable phase schizophrenia is characterized by altered patterning in tryptophan catabolites (TRYCATs) and memory impairments, which are associated with PHEMN (psychosis, hostility, excitation, mannerism and negative) and DAPS (depression, anxiety and physio-somatic) symptoms. This study was carried out to examine the association between TRYCAT patterning, memory impairments, psychopathological features and health-related quality of life (HR-QoL) in schizophrenia. The World Health Organization (WHO) QoL instrument-Abbreviated version (WHO-QoL-BREF), IgA/IgM responses to TRYCATs, cognitive tests, Scale for the Assessment of Negative Symptoms (SANS), Hamilton and Depression (HAMD) and Anxiety (HAMA) Rating Scales and the Fibromyalgia and Chronic Fatigue Syndrome Rating Scale (FF) were measured in 80 schizophrenia patients and 40 controls. Neural Network analysis shows that the total HR-Qol score is best predicted by (in descending order) FF, HAMA and SANS scores, Mini Mental State examination, hostility, ratio noxious/protective TRYCATs and HAMD score. Partial least Squares (PLS) analysis shows that 55.1% of the variance in Domain1 (physical) is predicted by PHEMN and DAPS latent vector (LV) scores, while 57.9% of domain2 (psychological), 32.7% of domain3 (social) and 55.0% of domain4 (environment) are explained by DAPS LV scores. TRYCATs and episodic/semantic memory impairments have specific indirect effects on domains 2, 3 and 4, which are mediated by DAPS symptoms, while the effects of TRYCATs on domain1 are mediated by PHEMN and DAPS symptoms. Picolinic acid, xanthurenic acid and 3-hydroxy-kynurenine decrease WHO-QoL scores, whilst anthranilic acid is protective..

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Oxidative stress in drug naïve first episode psychosis and antioxidant effects of risperidone

Cited by 61 publications

References 55 publications

Biomarkers and schizophrenia: a qualitative review

Biomarkers and schizophrenia: a qualitative review

The Effects of Prenatal Iron Deficiency and Risperidone Treatment on the Rat Frontal Cortex: A Proteomic Analysis

Supervised machine learning to decipher the complex associations between neuro-immune biomarkers and quality of life in schizophrenia

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