Oxidative stress in diabetic patients with retinopathy

Kundu, Debtosh; Mandal, Tanuka; Nandi, Mausumi; Osta, Manish; Bandyopadhyay, Ujjwal; Ray, Debes

doi:10.4103/1596-3519.126951

Cited by 18 publications

(11 citation statements)

References 15 publications

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“…Increase in serum TBARS in diabetes is attributed to increased oxidative stress and increased free radical production [ 14 , 19 , 20 , 26 – 29 ]. In our study, serum TBARS was significantly increased in diabetic patients (both with and without retinopathy) as compared to healthy controls as observed by earlier studies [ 30 – 36 ].…”

Section: Discussionsupporting

confidence: 90%

Serum Oxidized LDL Levels in Type 2 Diabetic Patients with Retinopathy in Mthatha Region of the Eastern Cape Province of South Africa

Ganjifrockwala

Joseph

George

2016

Oxidative Medicine and Cellular Longevity

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Oxidized low-density lipoprotein (ox-LDL) is a powerful natural prooxidant derived from native LDL by cell-mediated oxidation. Such oxidation occurs more easily in glycated LDL as observed in diabetes mellitus. We evaluated and compared selected biomarkers of oxidative stress and total antioxidant (TAO) levels in type 2 diabetes mellitus (T2DM) patients with and without retinopathy in the Mthatha region of the Eastern Cape Province, South Africa. The participants totaled to 140 and this number comprised 98 diabetic patients on treatment, stratified by diabetes (54) and diabetes with retinopathy (44). Forty-two nondiabetic healthy controls made up the 140. Fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), lipid profile, serum ox-LDL, thiobarbituric acid reactive substances (TBARS), and TAO levels were measured. A statistically significant increase in FPG, HbA1c, TBARS, and ox-LDL and a significant decrease in TAO levels were seen in T2DM patients with retinopathy as compared to controls. A significant negative correlation was observed between TAO and ox-LDL levels in the diabetic group. In multiple linear regression analyses, duration of diabetes, triglyceride, TAO, and LDL cholesterol were found to be significantly associated with ox-LDL. In multiple logistic regression analyses, ox-LDL [OR 1.02 (1.01–1.03), P = 0.005] was the only risk factor and was significantly associated with the presence of retinopathy.

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Section: Discussionsupporting

confidence: 90%

Serum Oxidized LDL Levels in Type 2 Diabetic Patients with Retinopathy in Mthatha Region of the Eastern Cape Province of South Africa

Ganjifrockwala

Joseph

George

2016

Oxidative Medicine and Cellular Longevity

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“…Ascorbic acid acts as a cofactor alongside many human enzymes and as a water-soluble antioxidant [155]. Vitamin C is present in higher concentration in healthy patients, contrary to those with DR who have lower concentrations than those diabetic patients who have not developed this complication [156]. Vitamin C prevents the propagation of free radical-induced chain reactions [157], and thus, directly scavenging ROS preventing breakdown of NO and decreasing low-density lipid oxidation [143, 158, 159] protects the endothelial barrier permeability by the inhibition of VEFG [160]; however, caution is indeed needed since ascorbate can act as a prooxidant in the presence of transition metal such as ionic iron or ferritin, both associated with diabetes [161].…”

Section: Influence Of Antioxidants In Diabetic Retinopathymentioning

confidence: 99%

Oxidative Stress as the Main Target in Diabetic Retinopathy Pathophysiology

Olvera-Montaño

Alberto

Navarro-Partida

et al. 2019

Journal of Diabetes Research

118

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Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus (DM) causing vision impairment even at young ages. There are numerous mechanisms involved in its development such as inflammation and cellular degeneration leading to endothelial and neural damage. These mechanisms are interlinked thus worsening the diabetic retinopathy outcome. In this review, we propose oxidative stress as the focus point of this complication onset.

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“…Oxidative stress induction contributed to the development of diabetic complications through production of mitochondrial ROS [37][38][39]. In addition, it has been shown that inhibition of diabetes-induced oxidative stress can be an effective strategy in control and prevention of the onset and progression of diabetic complications [40,41]. It has also been reported that total serum SA and PSA are in association with micro-and macrovascular complications including nephropathy, retinopathy, and hypertension in diabetic patients [42][43][44][45][46].…”

Section: Discussionmentioning

confidence: 99%

The correlation between blood oxidative stress and sialic acid content in diabetic patients with nephropathy, hypertension, and hyperlipidemia

et al. 2019

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This clinical study was designed to find out the correlation between oxidative stress and sialic acid (SA) content of plasma and RBCs in patients with type 2 diabetes. We evaluated SA concentration and oxidative stress biomarkers in healthy subjects and diabetic patients with and without complications in a cross-sectional survey. Significant changes in oxidative stress biomarkers and RBC-SA were revealed in the diabetic patients compared to those in the healthy group. Plasma SA significantly increased with an increase in lipid peroxidation of RBCs (LPO-RBC) (P < 0.001) in the diabetic patients without complication. RBC-SA significantly decreased with an elevation in LPO-RBC (P < 0.001) in all the diabetic patients and those with nephropathy. There was no significant correlation between plasma and RBC-SA and other oxidative stress biomarkers in the diabetic subjects. In multiple logistic regression analysis, RBC-SA was independently related to LPO-RBC in all the diabetic patients and those with nephropathy. We conclude that the induction of LPO-RBC in diabetic patients and those with nephropathy may influence the SA decomposition of RBC membrane, thereby altering its functions and transporter activities. Therefore, LPO-RBC and SA levels in RBCs can be used for prediction of diabetic nephropathy, and further studies to evaluate other factors contributing to desialylation of RBC membrane are justified.

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Oxidative stress in diabetic patients with retinopathy

Abstract: Estimation of HbA1c, MDA, GSH in erythrocytes, and vitamin C levels can contribute to determine the extent of oxidative stress in diabetes and help in effective control and prevention of the onset and progression of diabetic retinopathy.

Cited by 18 publications

References 15 publications

Serum Oxidized LDL Levels in Type 2 Diabetic Patients with Retinopathy in Mthatha Region of the Eastern Cape Province of South Africa

Serum Oxidized LDL Levels in Type 2 Diabetic Patients with Retinopathy in Mthatha Region of the Eastern Cape Province of South Africa

Oxidative Stress as the Main Target in Diabetic Retinopathy Pathophysiology

The correlation between blood oxidative stress and sialic acid content in diabetic patients with nephropathy, hypertension, and hyperlipidemia

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