Oxidative Stress in Diabetes. A model of complex thinking applied in medicine

Stoian, Anca Pantea; Mitrofan, Grigorina; Colceag, Florian; Suceveanu, Andra Iulia; Hainăroşie, Răzvan; Pițuru, Silviu; Diaconu, Camelia Cristina; Timofte, Daniel; Nițipir, Cornelia; Poiană, Cătălina; Serafinceanu, Cristian

doi:10.37358/rc.18.9.6566

Cited by 14 publications

(9 citation statements)

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“…The correlations between diabetes and glaucoma are controversial. Some studies have found diabetes to be a risk factor in glaucoma (42)(43)(44)(45)(46), and others find no correlation or even a negative correlation (47). In the present study, we found no correlation between these two frequent encountered pathologies, but only diabetic patients without diabetic retinopathy were included.…”

Section: Diastolic Hypotension (Dips)contrasting

confidence: 65%

“…In the present study, we found no correlation between these two frequent encountered pathologies, but only diabetic patients without diabetic retinopathy were included. Diabetic microcirculation impairment leads to retinal fiber layer damage by multiple pathological pathways: Oxidative stress, increased levels of retinal inflammation biomarkers and disruption of vasculo-retinal barrier (42,43,46).…”

Section: Diastolic Hypotension (Dips)mentioning

confidence: 99%

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Association between vascular comorbidity and glaucoma progression: A four-year observational study

et al. 2021

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Glaucoma, one of the significant causes of blindness worldwide, is a chronic optic neuropathy, characterized by progressive loss of retinal ganglion cells and specific perimetric defects. This study aimed to assess the association between the risk of glaucoma progression and different systemic vascular abnormalities. A 4-year prospective study was carried out on 204 patients diagnosed with open-angle glaucoma. Associated systemic vascular pathology was documented in 102 cases. Progression was encountered in 57 (55.9%) patients with vascular comorbidities and only in 10 (9.8%) patients with no associated vascular diseases (OR 13.81, P<0.01). The vascular risk factors associated with glaucoma progression in the study group were diastolic hypotension (OR 5.444, P=0.027), ischemic cardiac disease (OR 5.826; P<0.01), peripheral vasospasm (OR 3.108, P= 0.042) and arterial hypertension (OR 2.593, P=0.05). Diabetes was not significantly correlated with progression in the study group, but only patients without diabetic retinopathy were included. This study highlights that systemic comorbidities associated with endothelial lesions, atherosclerosis and hypoperfusion can lead to damage to the retinal nerve fiber layer and the underlying conjunctive tissue.

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Section: Diastolic Hypotension (Dips)contrasting

confidence: 65%

Section: Diastolic Hypotension (Dips)mentioning

confidence: 99%

Association between vascular comorbidity and glaucoma progression: A four-year observational study

et al. 2021

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“…According to the type of glucose disturbance, 16 patients had type 1 diabetes, and 123 had type 2 dyabetes, the rest having a genetic predisposition and occasionally increased glucose levels in the serum. [28] Inflammatory bowel diseases are also known to be significant risk factors, especially after 10-15 years of disease progression, the risk being bigger in Ulcerative Colitis than in Crohn's Disease. In our study, almost 8% of patients (60 patients) had a long history of IBDs.…”

Section: Resultsmentioning

confidence: 99%

Five Years Retrospective Review of Colorectal Cancer Risk Factors in the Black Sea Coast Population

Micu¹,

Oraiopoulou²,

Manea³

et al. 2020

Rev. Chim.

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Considering its increasing incidence, complications, comorbidities, mortality and last but not least the tendency to decrease the age of onset, colorectal cancer (CRC) represents one of the significant concerns related to oncology diseases becoming in the last decades a public health problem. Although the etiology is not yet completely known, colorectal cancer is considered a disease with multiple factors, an important place occupying the impact of the environmental factors on the genetically particularly predisposition of patients. In order to reduce the incidence of this disease, screening methods have been developed that are addressed primarily to the population at risk and which have contributed significantly to reducing the occurrence of this condition. The purpose of this paper is to evaluate the presence of specific risk factors for CRC in the Black Sea Coast population for a period of 5 years, and to contribute to the reinforcement of some notions already well known in the specialized literature. By publishing this work, the committee of authors hopes to strengthen the profile of the individual at risk of developing CRC in order to identify better those that are in danger of developing this disease and refer them to screenin

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“…These aspects could be of also correlated to some degree to our group latest interests in combinations that might exist between smoking status, exercise performing and oxidative stress status modifications [30][31][32][33].…”

Section: Resultsmentioning

confidence: 99%

The Biochemical Effect of Smoking on the Response to Chemotherapy

Miron¹,

Turcanu²,

Ciuntu³

et al. 2019

Rev. Chim.

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Improvements in early detection of cancer have led to an important decrease in mortality rates of cancer. Given the increased incidence rates and decreased mortality rates, the number of patients surviving cancer is rapidly increasing. Although cancer patients face many physical and psychological symptoms, they also continue to engage in poor health behaviors at rates similar to those of the general-healthy population. The prime example of such unhealthy behavior is smoking. The reports show that smoking rates at the time of diagnosis of cancer vary from 10% to 95%. Our study analyzed how the smoking status influenced the outcome of chemotherapy of 249 patients suffering from various forms of cancer. Our statistical analysis showed that patients who smoked had a significant different response to chemotherapy compared to their nonsmoking peers. This meant that in our sample of 149 cancer suffering patients, individuals who did not smoke had a significant better chance of a partial positive response after chemotherapy compared to patients who smoked regularly. Therefore, tobacco smoking is an adverse prognostic factor associated with a resistance to chemotherapy. These results are important given the fact that cancer patients already face a combination of unpleasant symptoms related to their disease but also from the side effects of their treatment. Uncovering the exact mechanisms through which smoking is affecting the outcome of chemotherapy may help in increasing the quality of life, the symptom burden or the final outcome of chemotherapy.

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Oxidative Stress in Diabetes. A model of complex thinking applied in medicine

Cited by 14 publications

References 1 publication

Association between vascular comorbidity and glaucoma progression: A four-year observational study

Association between vascular comorbidity and glaucoma progression: A four-year observational study

Five Years Retrospective Review of Colorectal Cancer Risk Factors in the Black Sea Coast Population

The Biochemical Effect of Smoking on the Response to Chemotherapy

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