Oxidative stress in chronic otitis media

Abstract

Chronic otitis media usually presents with a benign tumor-like lesion of the temporal bone known as a cholesteatoma. The role of oxidative stress in the pathogenesis of chronic otitis media and cholesteatoma has not yet been fully explored. Therefore, the aim of this study was to investigate the oxidative stress markers and antioxidant enzymes in patients with cholesteatomatous and noncholesteatomatous chronic otitis media and in healthy subjects. A prospective controlled trial was performed on cholesteatomatous and noncholesteatomatous chronic otitis media patients in a tertiary referral center in a university hospital. A total of 75 subjects, including 25 cholesteatomatous and 25 noncholesteatomatous chronic otitis media patients and 25 healthy subjects participated in this study. Serum total oxidant status (TOS) and oxidative stress index (OSI) levels were significantly increased in the patient groups with or without cholesteatoma compared with the control group. Serum total antioxidant status (TAS) levels and Paraoxonase and arylesterase activity were significantly lower in the patient groups with or without cholesteatoma compared with the control group. Serum TOS and OSI levels were lower in the noncholesteatomatous group, whereas serum TAS levels were higher compared with the cholesteatomatous group. Serum arylesterase activity was significantly lower in the noncholesteatomatous group compared with the control group. The results of this study reveal that in cholesteatoma cases, the oxidative stress and antioxidant enzyme imbalance were more significant than in cases of chronic otitis media without cholesteatoma.

Free Radicals and Oxidative Stress: Basic Concepts and Misconceptions

“…Moreover, Aksoy et al revealed an association of patients with allergic rhinitis to increased serum protein oxidation levels (Aksoy et al 2009(Aksoy et al , 2012. Other fi ndings add to the evidence that elevated serum oxidant levels and declined antioxidant status levels were observed in patients with chronic long-term otitis media (Garca et al 2013a ;Baysal et al 2013 ;Testa et al 2012 ).…”

“…Truly reactive radicals are those chemical species with one or two highly reactive unpaired valence electrons in open electron shell(s). A large body of evidence suggests that free radicals are linked to the pathogenesis of tumors (Manjunath et al 2010 ;Valko et al 2006 ;Dwivedi et al 2008 ), hearing loss (Yamasoba et al 2013 ;Rewerska et al 2013 ), tonsillitis (Garca et al 2013b ;Cvetkovic et al 2009 ;Yilmaz et al 2004 ;Li et al 2011 ), allergic rhinitis (Aksoy et al 2009(Aksoy et al , 2012, chronic otitis media (Garca et al 2013a ;Baysal et al 2013 ;Testa et al 2012 ), and rhinosinusitis (Citardi et al 2006 ;Uslu et al 2003 ) and implies that antioxidant therapy eventually may be employed as a strategy to ameliorate these disorders and diseases (Ding et al 2013 ;Tian et al 2013 ;Someya et al 2010 ). As has been shown recently, however, many antioxidants that are effective in animal models are not effective in human clinical trials.…”

The Role of p21 and p53 Proteins in Congenital Cholesteatoma

“…Cells undergoing p21-induced apoptosis presented higher sensitivity to oxidants (24). Recently Baysal et al (25) reveal that in cholesteatoma cases, the oxidative stress and antioxidant enzyme imbalance is significant. We may suspect some correlation between p21-induced apoptosis and oxidative stress in cholesteatoma.…”

Serum Myeloperoxidase Activity, Total Antioxidant Capacity and Nitric Oxide Levels in Patients with Chronic Otitis Media

“…This whole antioxidant defense in the body is defined as the TAC, which is in balance with oxidants in the healthy organism. In recent years, to determine the oxidative balance, serum TAC, a reliable parameter in the evaluation of antioxidant capacity, has been measured (Baysal et al 2013). …”