Oxidative Stress in Chronic Obstructive Pulmonary Disease

Repine, John E.; Bast, Aalt; Lankhorst, Ida

doi:10.1164/ajrccm.156.2.9611013

Cited by 739 publications

(463 citation statements)

References 228 publications

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“…8-hydroxydeoxyguanosine), lipid peroxidation products, and nitrated proteins in plasma [25,26]. In the present study, we used PC in plasma as an index for systemic oxidative status, but could, however, not find any significant difference between controls and COPD subjects.…”

Section: Discussionmentioning

confidence: 96%

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Kentson

Leanderson

Jacobson

et al. 2018

European Clinical Respiratory Journal

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Background: The pathogenesis of chronic obstructive pulmonary disease (COPD) is associated with oxidative stress. Both iron (Fe) and oxygen are involved in the chemical reactions that lead to increased formation of reactive oxygen species. Oxidative reactions are prevented by antioxidants such as carotenoids. Objective: To study the differences in Fe status, carotenoid levels, healthy eating habits, and markers of inflammation and oxidative damage on proteins in subjects with severe COPD ± long-term oxygen therapy (LTOT) and lung-healthy control subjects. Methods: Sixty-six Caucasians with advanced COPD (28 with LTOT) and 47 control subjects were included. Questionnaires about general health, lifestyle, and dietary habits were answered. Lung function tests and blood sampling were performed. Results: COPD subjects (±LTOT) did not demonstrate increased oxidative damage, assessed by protein carbonylation (PC), while levels of soluble transferrin receptors (sTfRs) were slightly elevated. Soluble TfRs, which is inversely related to Fe status, was negatively associated with PC. Levels of carotenoids, total and β-cryptoxanthin, α- and β-carotenes, were significantly lower in COPD subjects, and their diet contained significantly less fruits and vegetables. Lutein correlated inversely with IL-6, lycopene correlated inversely with SAT, while β-carotene was positively associated with a Mediterranean-like diet. Conclusions: Fe could favor oxidative stress in COPD patients, suggesting a cautious use of Fe prescription to these patients. COPD subjects ate a less healthy diet than control subjects did and would, therefore, benefit by dietary counseling. COPD patients with hypoxemia are probably in particular need of a lycopene-enriched diet.

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Section: Discussionmentioning

confidence: 96%

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Kentson

Leanderson

Jacobson

et al. 2018

European Clinical Respiratory Journal

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“…COPD is characterised by a loss of elastin from the alveolar wall (Merrilees et al 2008) and the ensuing progressive emphysema induces by alveolar enlargement, perenchymal destruction and loss of lung elasticity (Robbesom et al 2008). Two potential mechanisms are thought to play a role in the development of emphysema; first, a chronic imbalance between proteases, including neutrophil elastase, MMP-2 and -9, and protease inhibitors such as secretory leukoprotease inhibitor (Gadek et al 1984;Meyer et al 1998); and second, ROS-mediated DNA and protein damage as a result of infections or exposure to environmental pollutants (Repine et al 1997). Histologically, elastic fibres in the emphysematous lung appear fragmented, with a reduced microfibrillar component and evidence of disorganised elastin deposition (Fukuda et al 1989).…”

Section: Pulmonarymentioning

confidence: 99%

Tissue elasticity and the ageing elastic fibre

Sherratt

2009

AGE

263

189

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The ability of elastic tissues to deform under physiological forces and to subsequently release stored energy to drive passive recoil is vital to the function of many dynamic tissues. Within vertebrates, elastic fibres allow arteries and lungs to expand and contract, thus controlling variations in blood pressure and returning the pulmonary system to a resting state. Elastic fibres are composite structures composed of a cross-linked elastin core and an outer layer of fibrillin microfibrils. These two components perform distinct roles; elastin stores energy and drives passive recoil, whilst fibrillin microfibrils direct elastogenesis, mediate cell signalling, maintain tissue homeostasis via TGFβ sequestration and potentially act to reinforce the elastic fibre. In many tissues reduced elasticity, as a result of compromised elastic fibre function, becomes increasingly prevalent with age and contributes significantly to the burden of human morbidity and mortality. This review considers how the unique molecular structure, tissue distribution and longevity of elastic fibres pre-disposes these abundant extracellular matrix structures to the accumulation of damage in ageing dermal, pulmonary and vascular tissues. As compromised elasticity is a common feature of ageing dynamic tissues, the development of strategies to prevent, limit or reverse this loss of function will play a key role in reducing age-related morbidity and mortality.

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“…Selenium contributes to antioxidant defences as an essential coenzyme in glutathione peroxidase, and hence a low intake of selenium may increase susceptibility to COPD (Repine et al, 1997). Copper is also involved in antioxidant defences both extracellularly, when bound as ceruloplasmin (Al-Timimi & Dormandy, 1977;Goldstein et al, 1979;Gutteridge et al, 1980;A.D., Taylor & Oey, 1982), and intracellularly as a coenzyme for superoxide dismutase (Fridovich, 1978;Forsberg et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population

et al. 2005

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Background: Increased dietary intake of antioxidants has been associated with higher lung function, but few studies have used biological markers of antioxidant intake. Objective: This study aimed to determine if antioxidant status, as measured by blood levels, influences lung function. Design: Using a random subsample of 479 participants, aged 18-65 y old, from a larger cross-sectional observational study, the association of forced expiratory volume in 1 s (FEV 1 ) with plasma copper, vitamin C, vitamin E and serum selenium was assessed. Results: An s.d. increase in blood copper level was associated with a difference in FEV 1 of À48 ml (95% confidence intervals: À95, À2 ml, P ¼ 0.04), vitamin C þ 49 ml ( þ 4, þ 94, P ¼ 0.03), vitamin E À15 ml (À62, þ 32, P ¼ 0.53) and selenium þ 52 ml ( þ 7, þ 96, P ¼ 0.02). The sizes of association were not appreciably altered in a mutually adjusted model. Conclusions: Higher levels of serum vitamin C and selenium appear to be associated with higher FEV 1 . The association between higher serum copper and lower FEV 1 requires further study in view of the ubiquitous exposure to this mineral. Sponsorship: National Asthma Campaign and British Lung Foundation.

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Oxidative Stress in Chronic Obstructive Pulmonary Disease

Cited by 739 publications

References 228 publications

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Tissue elasticity and the ageing elastic fibre

Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population

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